Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
 18,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1988, a new plasmid profile was observed for Vibrio salmonicida isolated from cod (Gadus morhua) and Atlantic salmon (Salmo salar) in fish farms in northern Norway. This new plasmid profile, which consisted of plasmids of 61, 21, 3.4, and 2.8 megadaltons, is 1 of 11 plasmid profiles which have so far been observed for V. salmonicida. Plasmid profiling and plasmid DNA hybridization were used in epidemiological studies of cold-water vibriosis. Our results indicate that V. salmonicida was transmitted from Atlantic salmon to cod and vice versa. The 61-megadalton plasmid was found exclusively in V. salmonicida strains originating from northern Norway, which is the only area in which this plasmid has ever been observed. Plasmid DNA hybridization and restriction endonuclease analysis show that the plasmid DNA of V. salmonicida remained stable throughout a 7-year survey.
 ...
PMID:Plasmid profiling of Vibrio salmonicida for epidemiological studies of cold-water vibriosis in Atlantic salmon (Salmo salar) and cod (Gadus morhua). 216 Feb 18

On the basis of plasmid composition as well as serological and biochemical properties, 26 strains identified as Vibrio anguillarum isolated from diseased fish could be assigned to two different groups. Except for three reference strains, these++ strains were isolated from Norwegian fish. The four strains isolated from rainbow trout (Salmo gairdneri), the only strain isolated from char (Salvelinus alpinus), and three of six strains isolated from Atlantic salmon (Salmo salar) harbored a plasmid of 47 megadaltons (MDa). Restriction endonuclease analysis showed that this plasmid and the virulence plasmid pJM1, carried by V. anguillarum strain 775, were very similar but not identical. Strains harboring the 47-MDa plasmid had nearly identical biochemical properties and were serotype O1. Strains isolated from reared coastal cod (Gadus morhua), turbot (Scophthalmus maximus), halibut (Hippoglossus hippoglossus), free-living saithe (Pollachius virens), and partly from reared Atlantic salmon differed from strains harboring the 47-MDa virulence plasmid by not containing this plasmid, by having different biochemical traits, and by being serotype O2. Rainbow trout which were experimentally infected with a strain isolated from cod suffering from vibriosis developed clinical symptoms similar to those in cod but quite different from those usually seen in rainbow trout.
 ...
PMID:Relationships between plasmids and phenotypes of presumptive strains of Vibrio anguillarum isolated from different fish species. 272 84

Vibrio-like isolates from Atlantic salmon (Salmo salar Linnaeas) and a few from rainbow trout (S. gairdneri Richardson) suffering from hemorrhagic syndrome (Hitra disease), also called cold-water vibriosis, a disease of great importance in Norwegian fish farming, were examined for plasmid content. Of 84 strains isolated from 1982 to 1984, 70 (83.3%) had a common 21-megadalton (MDa) plasmid. A 3.4-MDa plasmid was found in 58 of the strains with the 21-MDa plasmid, and a 2.8-MDa plasmid was found in 23 of the strains with both the 21- and 3.4-MDa plasmids. The strains were isolated from fish farms along the western and northern coasts of Norway. Ten (11.9%) of the strains possessed a 61-MDa plasmid in addition to a 21-MDa plasmid. Two strains had only a 21-MDa plasmid. Of the 84-Vibrio-like isolates, 14 did not harbor plasmids identical in mass to any other plasmids found in this material. Vibrio salmonicida strains, 257 in all, isolated from salmonids with the same disease from the same area from July 1986 to July 1987, all possessed a 21-MDa plasmid, either alone or in addition to a 3.4-MDa plasmid, or a combination of 3.4- and 2.8-MDa plasmids. Six of the strains had a 5.5-MDa plasmid instead of the 3.4-MDa plasmid. The restriction endonuclease patterns of the plasmids of similar molecular mass reflected similar nucleotide sequences. The plasmid content detected in isolates of V. salmonicida obtained from a coastline of more than 2,000 km and over a period of almost 6 years is stable.
 ...
PMID:Plasmids in Vibrio salmonicida isolated from salmonids with hemorrhagic syndrome (Hitra disease). 284 46