Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
 18,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Restriction fragment length polymorphism (RFLP) in the alpha 1-antitrypsin gene region was studied in relation to chronic obstructive airway disease (COAD) and pneumoconiosis. Genomic DNA of 122 studied subjects was digested with Hind III restriction endonuclease and hybridized with the alpha 1-antitrypsin gene probe. In eight patients with COAD an unusual 10-kb restriction fragment was found hybridizing with the probe. Three of 70 patients were homozygotes for this variant allele and 5 were heterozygotes, showing the presence of two fragments, 2.7 kb and 10 kb. The presence of 10-kb restriction fragment seems to be related to the early development of COAD in studied subjects and therefore might be used as a genetic marker of the disease.
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PMID:Alpha 1-antitrypsin gene polymorphism related to respiratory system disease. 288 93

Moraxella catarrhalis is recognised as a major pathogen in chronic respiratory diseases. Patients with pneumoconiosis have repeated respiratory infections, and the control is very important for good prognosis. From 1988 to 1993, fifty strains of Moraxella catarrhalis were obtained from 9 patients with pneumoconiosis attended at Nagasaki Rosai Hospital. Restriction enzyme analysis of chromosomal DNA by Hind III. Hae III, Cla I was performed on 50 strains of M. catarrhalis. Twelve strains (56%) out of 23 isolates with interval of less than 5 months had identical bacterial restriction endonuclease digestion patterns with three different enzymes, and all isolates with interval more than 6 months had different patterns. Tweny out of 13 episodes by the same strains occurred during 3 months. The acquisition and clearance of M. catarrhalis from the respiratory tract is a dynamic process.
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PMID:[Recurrent respiratory tract infection caused by Moraxella catarrhalis in patients with pneumoconiosis]. 1035 88