Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.2 (endonuclease)
 18,621 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 77-year-old man who developed herpes zoster duplex with generalized eruptions is presented. Three strains of varicella-zoster virus (VZV) were isolated from 2 skin lesions of herpes zoster and one of the generalized eruptions. For strain differentiation, these 3 strains were investigated by restriction endonuclease analysis of the viral DNA. The 3 strains were identical, suggested that a single strain of VZV had been residing in a latent form in multiple spinal ganglions of this patient. We speculate that this strain of VZV in remote ganglions was reactivated by the operation of gastric cancer as a trigger, and, as a result, the 2 skin lesions of herpes zoster appeared, followed by development of generalized eruptions due to virus propagation from zoster lesions.
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PMID:[A case of herpes zoster duplex with generalized eruption--study of the pathogenesis of the eruptions]. 255 15

Restriction endonuclease analysis of varicella-zoster virus (VZV) DNA has been used in unraveling the complex epidemiology of VZV infections in individuals immunized with a live, attenuated varicella virus vaccine. Early rashes appearing within the first six weeks after vaccination are invariably due to vaccine virus. True breakthrough infections with wild-type VZV also occur in vaccinees. Five cases of zoster have been seen in leukemic children vaccinated while in remission. One case appeared 22 months after vaccination in the same general area as the inoculation. The virus isolated was vaccine derived. A second case of zoster appeared in a dermatome unrelated to the sites of vaccination approximately 19 months after apparently natural varicella. This virus was wild type. Vaccine virus can therefore establish latency and can later reactivate as herpes zoster.
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PMID:Molecular epidemiology of live, attenuated varicella virus vaccine in children with leukemia and in normal adults. 302 39

Varicella-zoster virus (VZV) was isolated from two separate sites in each of three patients with shingles (herpes zoster). The DNAs of the six VZV isolates were compared by high-resolution restriction endonuclease analysis with HindIII, KpnI, and HpaI. DNA cleavage patterns for each pair of VZV isolates were indistinguishable. These studies suggest that clinical shingles is the manifestation of a single VZV strain that becomes reactivated and causes both a viraemia and a dermatomal exanthem.
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PMID:DNA mapping of paired varicella-zoster virus isolates from patients with shingles. 613 71