Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.1 (S1 nuclease)
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Human Gene/Protein
pigeon homolog 13.1
Platelet-derived growth factor A-chain 12.1
C20orf72 11.5
MAZ protein 11.3
K12 protein 10.8
PPP1A 10.8
ATP1B 10.8
VLC1 10.6
IGF-binding protein 6 10.5
Parotid secretory protein 10.5
TGGCA-binding protein 10.5
efg 10.5
Myc-associated factor X 10.3
PGAM-B 10.3
55 kd protein 10.1
AK1 protein 10.1
alpha 2 type I collagen 10.1
NOLA2 9.9
Ribonuclease T2 9.9
int-1 protein 9.8
L-myc protein 9.6
MTABC3 9.6
NAGT 9.6
MHC class 1 antigen 9.6
Myc-associated zinc finger protein 9.6
Valyl-tRNA synthetase 9.5
TB3-1 9.5
GCET2 9.4
DRiP78 9.4
TR4 orphan receptor 9.4
P138 9.3
ribosomal protein L8 9.3
PGAM-M 9.3
alpha 1 collagen 9.2
RTEF-1 9.2
Ss blood group 9.2
ST8Sia III 9.2
G1L 9.1
ribonuclease T2 9.0
NAD-dependent methylenetetrahydrofolate dehydrogenase 9.0
opn 8.9
HIS1 8.9
beta-galactoside alpha-2,6-sialyltransferase 8.8
TnTf 8.8
epsilon globin 8.7
MLC-2 8.7
ORF-3 8.7
CSRP2 8.7
LYS5 8.7
single strand DNA-binding protein 8.7
beta-alanine synthase 8.7
DGKA 8.7
ATPase subunit 9 8.7
HGAL 8.6
gluconate kinase 8.6
cathepsin W 8.6
interleukin-11 receptor 8.5
CRS2 8.5
LACS 8.5
KOX 8.5
ribosomal protein L27 8.5
Nuclear respiratory factor 1 8.4
ATP1AL1 8.4
Pregnancy-specific beta 1-glycoprotein 8.4
HCA1 8.4
ribosomal protein S21 8.4
beta B1-crystallin 8.3
Mad4 8.3
Werner syndrome helicase 8.3
NVL 8.3
HSP70B' 8.3
DNA helicase B 8.3
galK 8.3
EMP2 8.3
COL13A1 8.3
BKLF 8.3
gastric H,K-ATPase 8.3
beta2-syntrophin 8.2
platelet-derived growth factor A-chain 8.2
pyruvate kinase L 8.2
more...
Disease
Hereditary orotic aciduria 12.1
activation of latent virus 9.0
HCA1 8.4
Behr 7.9
EDS IV 7.5
SHS 7.4
SHS 7.4
myeloblastosis 7.3
nRNA 7.3
VDDR 7.3
CMCT 7.2
HHG 7.0
histidinemia 6.9
Shope fibroma 6.9
lymphogranuloma 6.8
IS2 6.8
CCV 6.8
Stretches 6.7
IS3 6.7
EL1 6.6
hereditary persistence of fetal hemoglobin 6.5
IS1 6.5
citrullinemia 6.4
orf 6.3
orotic aciduria 6.2
Ehlers-Danlos syndrome type IV 6.1
crown gall 6.0
Leukocyte adhesion deficiency 6.0
ADA deficiency 6.0
FANCJ 5.9
TCC 5.7
HS3 5.7
AD2 5.6
sandfly fever 5.6
vaccinia 5.5
erythroleukemia 5.5
RPC 5.4
US1 5.4
Burnett 5.4
inclusion conjunctivitis 5.4
Faber 5.4
Endometrium 5.3
MPE 5.2
Endometrium 5.2
CP1 5.2
epidermodysplasia verruciformis 5.2
DMS 5.1
SLS 5.1
SLS 5.0
CSB 5.0
Gilbert 5.0
Choriocarcinoma 5.0
Rust 5.0
Rous sarcoma 5.0
Adenovirus 4.8
alpha thalassemia 4.8
CAA 4.7
reticuloendotheliosis 4.7
infectious hepatitis 4.7
mammary tumor 4.7
MPS VII 4.7
CAP 4.6
RP4 4.6
erythroblastosis 4.6
KPC 4.6
DBM 4.5
Shigella sonnei 4.5
PHS 4.4
avian sarcoma 4.4
CTX 4.3
herpes simplex 4.3
CAA 4.3
NS2 4.3
VPI 4.3
embryonal carcinoma 4.2
xeroderma pigmentosum 4.2
Aujeszky's disease 4.1
SM1 4.1
vibriosis 4.1
CSB 4.1
more...
Symptom
autodigestion 4.8
starvation 2.5
incoordination 2.3
twitching 2.1
hyperoxia 0.7
acidity -0.8
seizures -1.2
analgesia -1.7
collapse -1.7
weakness -2.1
diarrhea -2.7
Drug
Anthramycin 8.8
2'-Deoxyadenosine 8.4
URF 8.1
CS-514 7.4
Crotonaldehyde 7.4
DNase I 6.8
Deoxyadenosine 6.1
Florfenicol 5.9
Diamminedichloroplatinum 5.4
beta-Galactosidase 5.3
Propidium 5.1
Cobalamin 5.0
Adenosine deaminase 4.7
AraC 4.6
SMP 4.5
CTX 4.4
CTX 4.4
CTT 4.4
ISP 4.2
CTC 4.0
Gel 4.0
R1881 3.8
CTC 3.8
Pronase 3.7
CTX 3.6
G418 3.5
AGG 3.5
DEX 3.2
Oxaliplatin 3.2
TTC 3.2
Sodium nitroprusside 3.2
Bifidobacterium 3.2
IFN-beta 3.1
Luteinizing 3.1
MRC 2.9
Vitamin B12 2.8
CCL 2.7
ZnCl2 2.7
ZnCl2 2.7
ETS 2.7
CTA 2.6
Growth hormone 2.5
Growth hormone 2.5
TAC 2.4
NH3 2.3
NaI 2.3
NaI 2.3
NaI 2.3
NaI 2.3
ampicillin 2.2
Itraconazole 2.1
Mutagen 2.1
-deoxyadenosine 2.1
NAG 2.0
Paraffin 2.0
Estrogens 2.0
TAT 1.9
Fraction 1.8
lysine 1.7
AZT 1.7
ETA 1.6
ALA 1.6
CAM 1.6
AZT 1.5
Heme 1.5
ADM 1.5
IL-2 1.4
Retinoic acid 1.4
Kenyan 1.3
p75 1.2
ABC 1.0
Adriamycin 0.9
Albumin 0.9
IFN-gamma 0.9
Angiotensin II 0.8
caffeine 0.7
lactose 0.6
Asn 0.6
PTH 0.4
NADH 0.3
more...
Enzyme
S1 nuclease 13.1
exonuclease VII 11.2
dichloromethane dehalogenase 9.6
histidinol phosphate aminotransferase 9.2
clavaminate synthase 9.1
YgjG 8.8
ATP phosphoribosyltransferase 8.5
venom phosphodiesterase 8.3
steroid 17alpha-hydroxylase 8.2
xanthine phosphoribosyltransferase 7.9
oligoribonuclease 7.9
valyl-tRNA synthetase 7.8
SMT1 7.8
EC 1.1.1.82 7.7
caffeoyl-CoA O-methyltransferase 7.7
gluconokinase 7.6
RNase T1 7.6
alpha-aminoadipate reductase 7.6
exonuclease I 7.6
chloramphenicol acetyltransferase 7.5
maleylacetate reductase 7.5
elongation factor (EF) 7.4
inositol dehydrogenase 7.4
GMP synthase 7.3
phosphoribosylanthranilate isomerase 7.3
3'-exonuclease 7.2
pyrroline-5-carboxylate dehydrogenase 7.2
polynucleotide kinase 7.2
6-phosphogluconate dehydratase 7.1
cyanase 7.0
agmatine deiminase 7.0
RNase D 7.0
RNase III 7.0
aspartate semialdehyde dehydrogenase 7.0
endonuclease VII 7.0
stringent factor 7.0
homocitrate synthase 6.9
DNase II 6.9
nicotinic acid phosphoribosyltransferase 6.9
carboxypeptidase S 6.9
carboxyl proteinase 6.9
D-serine dehydratase 6.8
micrococcal nuclease 6.8
type 1 protein phosphatase 6.7
STK3 6.7
EC 2.4.99.1 6.6
polynucleotide phosphorylase 6.6
pyruvate formate-lyase 6.5
dihydroorotase 6.5
argininosuccinate synthetase 6.5
H,K-ATPase 6.4
galactokinase 6.4
carbamoylphosphate synthetase 6.4
lambda exonuclease 6.4
ribose-5-phosphate isomerase 6.3
aspartyl-tRNA synthetase 6.2
Escherichia coli exonuclease III 6.2
RNase H 6.2
amidophosphoribosyltransferase 6.2
exoribonuclease 6.2
isoleucyl-tRNA synthetase 6.1
glycyl-tRNA synthetase 6.1
T-protein 6.1
signal peptidase II 6.0
endodeoxyribonuclease 6.0
catechol oxidase 6.0
arginyl-tRNA synthetase 6.0
endonuclease 6.0
acetoacetyl-CoA reductase 5.9
formyltetrahydrofolate synthetase 5.9
GalT 5.9
GMP synthetase 5.9
DNase 5.9
prephenate dehydratase 5.8
endoproteinase Asp-N 5.8
RNase 5.8
p-hydroxybenzoate hydroxylase 5.8
fatty-acid synthase 5.8
RNase 5.8
EPSP synthase 5.8
more...
Compound
Yellow pigment 9.6
NAAAF 9.5
Chartreusin 9.0
4-Aminobiphenyl 8.8
2-aminocyclopentanecarboxylic acid 8.0
Poly C 7.6
Angelicin 7.6
SHS 7.4
phosphonoacetic acid 6.9
alpha-Amanitin 6.9
Cesium chloride 6.8
XMP 6.8
13-cis-Retinoic acid 6.6
3'-AMP 6.6
dGMP 6.6
Diethyl pyrocarbonate 6.5
HSM 6.4
Canavanine 6.3
DAHP 6.3
DMS 6.3
2-butenal 6.3
SP 1 6.2
Diamminedichloroplatinum 6.2
Deoxyadenosine 6.2
MPE 6.1
TRU 6.1
CBN 5.9
TCN 5.8
HMBA 5.8
formamide 5.7
TCC 5.6
C56 5.6
Pectate 5.6
PPA 5.5
7-methylguanosine 5.5
HN2 5.4
Deoxyribonucleic acid 5.4
Silver, 5.4
G20 5.4
dCMP 5.4
Agarose 5.4
Actinomycin 5.3
dCTP 5.3
SP-1 5.3
TIF 5.3
TAA 5.2
Selenocysteine 5.2
G 1 5.1
CAT 5.1
CAT 5.1
MPC 5.1
Cobalamin 5.0
CAT 5.0
pyrimidine 5.0
DLG 5.0
D-Serine 5.0
pyrimidine 5.0
dGTP 5.0
UMP 4.9
MnO4 4.9
methylguanosine 4.9
Cordycepin 4.9
Cordycepin 4.9
Cordycepin 4.8
Psoralen 4.8
Sitosterol 4.7
CAA 4.7
BAL 4.7
TTA 4.6
HAP 4.6
Ethidium bromide 4.6
CAP 4.6
Guanine 4.6
COS 4.6
Gliotoxin 4.6
DBM 4.6
Thymine 4.6
DBM 4.5
ENU 4.5
TBE 4.5
more...