Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.30.1 (S1 nuclease)
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Human Gene/Protein
pigeon homolog 13.1
Platelet-derived growth factor A-chain 12.1
C20orf72 11.5
MAZ protein 11.3
PPP1A 10.8
K12 protein 10.8
ATP1B 10.8
VLC1 10.6
Parotid secretory protein 10.5
efg 10.5
TGGCA-binding protein 10.5
IGF-binding protein 6 10.5
Myc-associated factor X 10.3
PGAM-B 10.3
55 kd protein 10.1
alpha 2 type I collagen 10.1
AK1 protein 10.1
Ribonuclease T2 9.9
NOLA2 9.9
int-1 protein 9.8
NAGT 9.6
L-myc protein 9.6
MTABC3 9.6
MHC class 1 antigen 9.6
Myc-associated zinc finger protein 9.6
TB3-1 9.5
Valyl-tRNA synthetase 9.5
TR4 orphan receptor 9.4
GCET2 9.4
DRiP78 9.4
PGAM-M 9.3
ribosomal protein L8 9.3
P138 9.3
ST8Sia III 9.2
alpha 1 collagen 9.2
RTEF-1 9.2
Ss blood group 9.2
G1L 9.1
ribonuclease T2 9.0
NAD-dependent methylenetetrahydrofolate dehydrogenase 9.0
opn 8.9
HIS1 8.9
beta-galactoside alpha-2,6-sialyltransferase 8.8
TnTf 8.8
MLC-2 8.7
epsilon globin 8.7
DGKA 8.7
ORF-3 8.7
CSRP2 8.7
LYS5 8.7
beta-alanine synthase 8.7
single strand DNA-binding protein 8.7
ATPase subunit 9 8.7
HGAL 8.6
gluconate kinase 8.6
cathepsin W 8.6
LACS 8.5
interleukin-11 receptor 8.5
ribosomal protein L27 8.5
KOX 8.5
CRS2 8.5
Nuclear respiratory factor 1 8.4
ATP1AL1 8.4
HCA1 8.4
Pregnancy-specific beta 1-glycoprotein 8.4
ribosomal protein S21 8.4
HSP70B' 8.3
Werner syndrome helicase 8.3
beta B1-crystallin 8.3
NVL 8.3
Mad4 8.3
DNA helicase B 8.3
galK 8.3
BKLF 8.3
COL13A1 8.3
EMP2 8.3
gastric H,K-ATPase 8.3
ALC1 8.2
beta2-syntrophin 8.2
asnS 8.2
platelet-derived growth factor A-chain 8.2
type XIII collagen 8.2
ST6GALNAC2 8.2
gcv 8.2
14-3-3 eta 8.2
pyruvate kinase L 8.2
alpha 2,6-sialyltransferase 8.2
hTid-1 8.2
serine:pyruvate aminotransferase 8.2
C1-tetrahydrofolate synthase 8.2
ribosomal protein L30 8.2
EPLIN 8.1
beta enolase 8.1
F1 beta subunit 8.1
MT-IG 8.1
TnTs 8.1
Microtubule-associated protein 1B 8.1
OTF-1 8.0
UCE 8.0
NOT2 8.0
Early growth response protein 1 8.0
speckle-type POZ protein 8.0
transient receptor potential canonical 1 8.0
MYC-associated zinc finger protein 8.0
NADH dehydrogenase subunit 3 8.0
ribosomal protein S15 8.0
MZF1 8.0
PFK-M 8.0
serine threonine protein kinase 7.9
amino acid hydroxylase 7.9
ceruloplasmin mRNA 7.9
H4 histone 7.9
ATPase mRNA 7.9
valyl-tRNA synthetase 7.9
aprt 7.9
genomic clone 7.9
LYS2 7.9
CAS1 7.8
ENH 7.8
MLC1A 7.8
transducin alpha 7.8
LEU1 7.8
PUT1 7.8
E2DH 7.8
NHP2 7.8
transcription factor Sp1 7.7
N-myc protein 7.7
C4A2 7.7
Evi-1 7.7
peptidase D 7.7
GNAT2 7.7
cytochrome oxidase subunit II 7.7
myeloid zinc finger 7.7
alternatively spliced product 7.7
SARP 7.7
CRACC 7.7
alpha tropomyosin 7.6
ORF4 7.6
RFI 7.6
ribosomal protein L3 7.6
ST8Sia II 7.6
microfibril-associated glycoprotein 7.6
ribosomal protein L29 7.6
syncollin 7.6
blk 7.6
FPP synthetase 7.6
alpha myosin heavy chain 7.6
DNA-directed RNA polymerase 7.5
OX-2 7.5
FUSE-binding protein 7.5
ORF-2 7.5
PROS 7.4
ornithine decarboxylase antizyme 7.4
PRPS1 7.4
KAC 7.4
Sab 7.4
SHS 7.4
BI-1 7.4
exonuclease I 7.4
PSMA3 7.4
more...
Disease
Hereditary orotic aciduria 12.1
activation of latent virus 9.0
HCA1 8.4
Behr 7.9
EDS IV 7.5
SHS 7.4
SHS 7.4
myeloblastosis 7.3
nRNA 7.3
VDDR 7.3
CMCT 7.2
HHG 7.0
histidinemia 6.9
Shope fibroma 6.9
lymphogranuloma 6.8
IS2 6.8
CCV 6.8
IS3 6.7
Stretches 6.7
EL1 6.6
hereditary persistence of fetal hemoglobin 6.5
IS1 6.5
citrullinemia 6.4
orf 6.3
orotic aciduria 6.2
Ehlers-Danlos syndrome type IV 6.1
crown gall 6.0
Leukocyte adhesion deficiency 6.0
ADA deficiency 6.0
FANCJ 5.9
TCC 5.7
HS3 5.7
AD2 5.6
sandfly fever 5.6
vaccinia 5.5
erythroleukemia 5.5
RPC 5.4
US1 5.4
Burnett 5.4
inclusion conjunctivitis 5.4
Faber 5.4
Endometrium 5.3
Endometrium 5.2
MPE 5.2
CP1 5.2
epidermodysplasia verruciformis 5.2
DMS 5.1
SLS 5.1
SLS 5.0
CSB 5.0
Gilbert 5.0
Choriocarcinoma 5.0
Rust 5.0
Rous sarcoma 5.0
Adenovirus 4.8
alpha thalassemia 4.8
CAA 4.7
reticuloendotheliosis 4.7
infectious hepatitis 4.7
mammary tumor 4.7
MPS VII 4.7
CAP 4.6
RP4 4.6
erythroblastosis 4.6
KPC 4.6
DBM 4.5
Shigella sonnei 4.5
PHS 4.4
avian sarcoma 4.4
CTX 4.3
herpes simplex 4.3
CAA 4.3
NS2 4.3
VPI 4.3
embryonal carcinoma 4.2
xeroderma pigmentosum 4.2
Aujeszky's disease 4.1
SM1 4.1
vibriosis 4.1
CSB 4.1
plasma cell leukemia 4.0
PAL 4.0
WS2 4.0
osteogenesis imperfecta 4.0
amelanotic melanoma 3.9
NCR 3.9
MLS 3.9
African swine fever 3.9
testicular feminization 3.8
juvenile periodontitis 3.8
pyometra 3.8
Beard 3.8
genetic hypertension 3.7
hemophilia B 3.7
FDC 3.7
dyskeratosis congenita 3.6
CVS 3.6
Rift Valley fever 3.6
Marek's disease 3.6
parvovirus 3.6
Klebsiella 3.6
varicella 3.6
TTP 3.6
molluscum contagiosum 3.5
Spinocerebellar ataxia 3.5
DIP 3.4
Wells 3.4
cowpox 3.4
Fanconi syndrome 3.4
MSD 3.3
beta thalassemia 3.3
Burkitt's lymphoma 3.3
MAR 3.3
ACD 3.3
pituitary tumor 3.3
pseudohypoparathyroidism 3.3
Familial hypercholesterolemia 3.2
Glanzmann's thrombasthenia 3.2
maple syrup urine disease 3.2
Fraser 3.2
HP1 3.2
CDA 3.1
gestational trophoblastic disease 3.1
PTP 3.1
LCA 3.1
Li-Fraumeni syndrome 3.1
thalassemia 3.1
avian leukosis 3.1
papilloma 3.1
Roth 3.0
MLC 3.0
TTP 3.0
Delhi 3.0
invasive cervical cancer 3.0
mitochondrial myopathy 3.0
plasmacytoma 3.0
ADH 3.0
PER 2.9
Cockayne syndrome 2.9
EL4 2.9
PCC 2.9
bovine leukemia 2.9
HTLV-I 2.8
insulinoma 2.8
tubular necrosis 2.8
PHA 2.8
pseudotuberculosis 2.8
blast crisis 2.8
trachoma 2.8
CCL 2.8
RCM 2.7
Schmidt 2.7
T-cell lymphomas 2.7
Esophageal squamous cell carcinoma 2.7
CAM 2.6
CEM 2.6
Epstein 2.6
Fox 2.6
pheochromocytoma 2.6
lysosomal storage disease 2.5
more...
Symptom
autodigestion 4.8
starvation 2.5
incoordination 2.3
twitching 2.1
hyperoxia 0.7
acidity -0.8
seizures -1.2
analgesia -1.7
collapse -1.7
weakness -2.1
diarrhea -2.7
Drug
Anthramycin 8.8
2'-Deoxyadenosine 8.4
URF 8.1
CS-514 7.4
Crotonaldehyde 7.4
DNase I 6.8
Deoxyadenosine 6.1
Florfenicol 5.9
Diamminedichloroplatinum 5.4
beta-Galactosidase 5.3
Propidium 5.1
Cobalamin 5.0
Adenosine deaminase 4.7
AraC 4.6
SMP 4.5
CTX 4.4
CTX 4.4
CTT 4.4
ISP 4.2
CTC 4.0
Gel 4.0
R1881 3.8
CTC 3.8
Pronase 3.7
CTX 3.6
G418 3.5
AGG 3.5
DEX 3.2
Oxaliplatin 3.2
TTC 3.2
Sodium nitroprusside 3.2
Bifidobacterium 3.2
IFN-beta 3.1
Luteinizing 3.1
MRC 2.9
Vitamin B12 2.8
CCL 2.7
ZnCl2 2.7
ZnCl2 2.7
ETS 2.7
CTA 2.6
Growth hormone 2.5
Growth hormone 2.5
TAC 2.4
NH3 2.3
NaI 2.3
NaI 2.3
NaI 2.3
NaI 2.3
ampicillin 2.2
Itraconazole 2.1
Mutagen 2.1
-deoxyadenosine 2.1
NAG 2.0
Paraffin 2.0
Estrogens 2.0
TAT 1.9
Fraction 1.8
lysine 1.7
AZT 1.7
ETA 1.6
ALA 1.6
CAM 1.6
AZT 1.5
Heme 1.5
ADM 1.5
IL-2 1.4
Retinoic acid 1.4
Kenyan 1.3
p75 1.2
ABC 1.0
Adriamycin 0.9
Albumin 0.9
IFN-gamma 0.9
Angiotensin II 0.8
caffeine 0.7
lactose 0.6
Asn 0.6
PTH 0.4
NADH 0.3
CSF 0.2
THF 0.1
Biopolymers 0.0
nitroglycerin -0.0
ROS -0.1
MAP -0.9
vitamin E -1.0
ascorbate -1.4
Monit -2.0
Dermatol -2.3
Enzyme
S1 nuclease 13.1
exonuclease VII 11.2
dichloromethane dehalogenase 9.6
histidinol phosphate aminotransferase 9.2
clavaminate synthase 9.1
YgjG 8.8
ATP phosphoribosyltransferase 8.5
venom phosphodiesterase 8.3
steroid 17alpha-hydroxylase 8.2
xanthine phosphoribosyltransferase 7.9
oligoribonuclease 7.9
valyl-tRNA synthetase 7.8
SMT1 7.8
EC 1.1.1.82 7.7
caffeoyl-CoA O-methyltransferase 7.7
gluconokinase 7.6
RNase T1 7.6
alpha-aminoadipate reductase 7.6
exonuclease I 7.6
chloramphenicol acetyltransferase 7.5
maleylacetate reductase 7.5
elongation factor (EF) 7.4
inositol dehydrogenase 7.4
phosphoribosylanthranilate isomerase 7.3
GMP synthase 7.3
3'-exonuclease 7.2
pyrroline-5-carboxylate dehydrogenase 7.2
polynucleotide kinase 7.2
6-phosphogluconate dehydratase 7.1
cyanase 7.0
RNase D 7.0
agmatine deiminase 7.0
RNase III 7.0
aspartate semialdehyde dehydrogenase 7.0
endonuclease VII 7.0
stringent factor 7.0
homocitrate synthase 6.9
DNase II 6.9
carboxypeptidase S 6.9
nicotinic acid phosphoribosyltransferase 6.9
carboxyl proteinase 6.9
D-serine dehydratase 6.8
micrococcal nuclease 6.8
type 1 protein phosphatase 6.7
STK3 6.7
EC 2.4.99.1 6.6
polynucleotide phosphorylase 6.6
pyruvate formate-lyase 6.5
dihydroorotase 6.5
argininosuccinate synthetase 6.5
H,K-ATPase 6.4
galactokinase 6.4
carbamoylphosphate synthetase 6.4
lambda exonuclease 6.4
ribose-5-phosphate isomerase 6.3
aspartyl-tRNA synthetase 6.2
Escherichia coli exonuclease III 6.2
RNase H 6.2
amidophosphoribosyltransferase 6.2
exoribonuclease 6.2
isoleucyl-tRNA synthetase 6.1
glycyl-tRNA synthetase 6.1
T-protein 6.1
signal peptidase II 6.0
endodeoxyribonuclease 6.0
catechol oxidase 6.0
arginyl-tRNA synthetase 6.0
endonuclease 6.0
formyltetrahydrofolate synthetase 5.9
acetoacetyl-CoA reductase 5.9
GalT 5.9
GMP synthetase 5.9
DNase 5.9
prephenate dehydratase 5.8
endoproteinase Asp-N 5.8
RNase 5.8
fatty-acid synthase 5.8
p-hydroxybenzoate hydroxylase 5.8
RNase 5.8
EPSP synthase 5.8
glycine N-methyltransferase 5.8
tryptophanyl-tRNA synthetase 5.7
p-hydroxybenzoate hydroxylase 5.7
ubiquinol-cytochrome c oxidoreductase 5.7
DD-carboxypeptidase 5.7
RNA polymerase 5.7
dehydroquinase 5.7
3'-phosphatase 5.7
TRS 5.7
PBP5 5.7
DNA ligase 5.6
DNA ligase 5.6
threonine deaminase 5.6
triose-phosphate isomerase 5.5
phosphoglyceromutase 5.5
ribonuclease 5.4
ribonuclease 5.4
EC 1.1.1.40 5.4
seryl-tRNA synthetase 5.4
mannosidase I 5.4
beta-1,4-galactosyltransferase 5.3
NAD+ oxidoreductase 5.3
thymidine kinase 5.3
alpha-sarcin 5.3
dihydrodiol dehydrogenase 5.3
ADE2 5.2
histidase 5.2
LexA repressor 5.2
DNA polymerase 5.2
mercuric reductase 5.2
PRPP synthetase 5.2
NCP 5.2
isoamylase 5.1
HVS 5.1
BAL 5.1
lysyl endopeptidase 5.1
coproporphyrinogen oxidase 5.1
proline oxidase 5.0
thymidylate synthase 5.0
aspartate transcarbamylase 4.9
thymidylate kinase 4.9
21-hydroxylase 4.9
leucyl-tRNA synthetase 4.9
firefly luciferase 4.8
proteinase K 4.8
levansucrase 4.7
rubisco 4.7
orotidine-5'-phosphate decarboxylase 4.7
orotate phosphoribosyltransferase 4.7
RNA ligase 4.7
RNase P 4.7
beta-galactosidase 4.7
ALA synthase 4.7
type III procollagen 4.7
restriction-modification system 4.6
anthranilate synthase 4.6
reductoisomerase 4.6
phenylalanyl-tRNA synthetase 4.6
peptidylarginine deiminase 4.6
pullulanase 4.6
deoxyribonuclease 4.6
catechol 2,3-dioxygenase 4.5
catechol 1,2-dioxygenase 4.5
sialyltransferase 4.5
sialyltransferase 4.5
sialyltransferase 4.5
methionyl-tRNA synthetase 4.5
phytoene synthase 4.5
nitrilase 4.5
beta-xylosidase 4.5
aspartokinase 4.4
xylose isomerase 4.4
succinyl-CoA synthetase 4.4
methanol dehydrogenase 4.4
hypoxanthine-guanine phosphoribosyltransferase 4.4
carnitine acetyltransferase 4.4
carboxypeptidase Y 4.3
cyclohydrolase 4.3
lignin peroxidase 4.3
trehalase 4.3
more...
Compound
Yellow pigment 9.6
NAAAF 9.5
Chartreusin 9.0
4-Aminobiphenyl 8.8
2-aminocyclopentanecarboxylic acid 8.0
Poly C 7.6
Angelicin 7.6
SHS 7.4
phosphonoacetic acid 6.9
alpha-Amanitin 6.9
Cesium chloride 6.8
XMP 6.8
13-cis-Retinoic acid 6.6
3'-AMP 6.6
dGMP 6.6
Diethyl pyrocarbonate 6.5
HSM 6.4
Canavanine 6.3
DAHP 6.3
DMS 6.3
2-butenal 6.3
SP 1 6.2
Diamminedichloroplatinum 6.2
Deoxyadenosine 6.2
MPE 6.1
TRU 6.1
CBN 5.9
TCN 5.8
HMBA 5.8
formamide 5.7
TCC 5.6
C56 5.6
Pectate 5.6
PPA 5.5
7-methylguanosine 5.5
HN2 5.4
Deoxyribonucleic acid 5.4
Silver, 5.4
G20 5.4
dCMP 5.4
Agarose 5.4
Actinomycin 5.3
dCTP 5.3
SP-1 5.3
TIF 5.3
TAA 5.2
Selenocysteine 5.2
G 1 5.1
CAT 5.1
CAT 5.1
MPC 5.1
Cobalamin 5.0
CAT 5.0
pyrimidine 5.0
DLG 5.0
D-Serine 5.0
pyrimidine 5.0
dGTP 5.0
UMP 4.9
MnO4 4.9
methylguanosine 4.9
Cordycepin 4.9
Cordycepin 4.9
Cordycepin 4.8
Psoralen 4.8
Sitosterol 4.7
CAA 4.7
BAL 4.7
TTA 4.6
HAP 4.6
Ethidium bromide 4.6
CAP 4.6
Guanine 4.6
COS 4.6
Gliotoxin 4.6
DBM 4.6
Thymine 4.6
DBM 4.5
ENU 4.5
TBC 4.5
TBE 4.5
40S 4.5
PTU 4.5
DNA 4.4
D-gluconate 4.4
CAP 4.4
TGT 4.4
A 3 4.4
Dibutyryl cyclic AMP 4.3
Dibutyryl cyclic AMP 4.3
Porphyrin 4.2
MSM 4.2
A 1 4.2
Porphyrin 4.1
OMP 4.1
L-threonine 4.1
beta-D-galactoside 4.1
Protoporphyrin IX 4.1
dATP 4.1
Chlorophyll a 4.1
UTP 4.1
Tigecycline 4.0
UGA 4.0
HOG 4.0
B17 4.0
AF-2 4.0
carbamyl phosphate 3.9
Protamine 3.9
Trimethoprim 3.9
Cycloheximide 3.9
methyl methanesulfonate 3.8
PTU 3.8
PNA 3.8
G3P 3.8
ATF 3.8
CAM 3.8
TET 3.7
TET 3.7
CDH 3.7
Methylglyoxal 3.7
CMP 3.7
MgCl2 3.6
alcohol dehydrogenase 3.6
DAMP 3.6
TMP 3.6
Histidine 3.6
CTX 3.6
m-xylene 3.6
UDP-galactose 3.6
BUdR 3.6
Adenine 3.6
alpha-MSH 3.5
TTC 3.5
DEP 3.5
isonicotinic acid 3.5
ATA 3.5
L-PAM 3.5
L-PAM 3.5
tetradecyl 3.5
tetradecyl 3.5
IMP 3.5
Guo 3.4
acridine 3.4
uridine 3.4
PMA 3.4
Formate 3.4
MAD 3.4
DEAE 3.4
HMM 3.4
Polypeptide 3.4
BAP 3.4
ubiquinol 3.3
Lac 3.3
DEX 3.3
BAA 3.3
BRL 3.3
Pima 3.2
Adenine 3.2
bis(2-chloroethyl) 3.2
CDA 3.2
more...