Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.9 (glucose-6-phosphatase)
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Human Gene/Protein
serum/glucocorticoid regulated kinase 2 13.3
Hepatic nuclear factor 4 alpha 13.3
glucose-6-phosphatase 13.3
GSD1a 12.3
glucose-6-phosphate transporter 12.2
G6PT 12.1
G6PC3 11.9
Glucose-6-phosphatase 11.9
SLC37A4 11.8
NPT3 11.8
G6Pase 11.7
SPX3 11.5
SLC37A2 11.3
phosphoenolpyruvate carboxykinase 1 11.1
ATP6V1D 11.0
G6F 11.0
fructose-bisphosphatase 10.9
TCDD-inducible poly(ADP-ribose) polymerase 10.8
phosphoenolpyruvate carboxykinase 10.7
dihydrolipoamide S-succinyltransferase 10.5
pyruvate kinase L 10.5
fructose-1,6-bisphosphatase 10.4
PEPCK-M 10.4
islet-specific glucose-6-phosphatase catalytic subunit-related protein 10.4
CRHSP-24 10.3
Succinic dehydrogenase 10.3
NPT4 10.3
phosphoinositide-3-kinase, catalytic, alpha polypeptide 10.2
liver glycogen synthase 10.2
B4GALT3 10.0
PEPCK-C 10.0
CL-6 9.9
glucokinase 9.9
1-acylglycerol-3-phosphate O-acyltransferase 2 9.9
phosphorylase, glycogen 9.9
PEPCK 9.9
SLC37A1 9.8
ZHX3 9.8
ZFP91 9.8
liver glycogen phosphorylase 9.7
more...
Disease
GSD I 12.1
Essential fructosuria 11.3
Glycogen storage disease type Ib 11.3
Hepatic glycogenosis 11.2
GSD 10.9
GSD 10.7
glycogen storage disease 10.5
Fanconi-like syndrome 10.2
Hers 10.0
fructose-1,6-diphosphatase deficiency 9.9
GSD IX 9.2
Hepatic impairment 8.7
Fasting hypoglycemia 8.6
disorders of carbohydrate metabolism 8.5
Extrahepatic cholestasis 7.9
porcine stress syndrome 7.5
hepatic adenoma 7.5
severe congenital neutropenia 7.3
Hepatocarcinogenesis 7.3
Tauri 7.1
Farber 7.0
Forbes 6.8
Oral ulcers 6.6
Klebs 6.6
diabetic hyperglycemia 6.5
hyperuricemia 6.4
favism 6.3
MODY3 6.3
Hepatic necrosis 6.2
hypoglycemia 6.2
hyperglycemia 6.2
xanthomatosis 6.1
postmaturity 6.1
HCA 6.0
metabolic disorder 6.0
AIN 6.0
enzyme deficiency 5.9
lactic acidosis 5.8
hereditary fructose intolerance 5.7
hyperinsulinemia 5.7
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Symptom
hepatomegaly 6.7
bradypnea 5.7
Cushingoid 5.6
Cushingoid 5.5
Decreased activity 5.3
autodigestion 5.0
polydipsia 4.2
ketonuria 4.2
polyuria 4.1
starvation 4.0
emaciation 3.3
menopausal symptoms 2.7
lethargy 2.4
acute stress 2.2
hypotonia 1.8
splenomegaly 1.7
anorexia 1.6
hepatosplenomegaly 1.2
exhaustion 1.2
cachexia 0.9
hunger 0.9
hypothermia 0.8
acidity 0.4
weakness 0.1
constipation 0.0
Ill -0.1
diarrhea -0.2
ataxia -0.6
anesthesia -0.8
respiratory distress -0.9
overweight -1.4
collapse -1.5
abdominal pain -1.6
vomiting -1.6
seizures -2.0
pain -4.7
Drug
Phenobarbital sodium 9.2
Hetrazan 8.8
Pegaspargase 8.2
Iron dextran 7.8
1-Deoxynojirimycin 7.7
Insulin lispro 7.6
Esculin 7.3
Tiopronin 7.2
Pyridoxamine 7.1
Ciprofibrate 7.0
Fructose 6.5
Corn oil 6.1
Nitazoxanide 6.0
Fenbendazole 6.0
Monosodium glutamate 6.0
Pentostam 6.0
CrCl3 5.8
Glucagon 5.8
Carbenoxolone 5.8
Swertia 5.4
Asparaginase 5.3
Pyridoxal 5.3
Troglitazone 5.3
Rosiglitazone 5.3
Bezafibrate 5.2
Fraction 5.2
Palmitoyl 5.1
Myricetin 5.1
NADH 4.8
Dextrose 4.7
beta-Galactosidase 4.6
Liraglutide 4.6
Glycerol 4.5
ISP 4.4
Emodin 4.4
AmBisome 4.3
Cellulase 4.3
Orphan 4.3
Clofibrate 4.2
Emodin 4.2
more...
Enzyme
glucose-6-phosphatase 13.3
glycerin-3-phosphate dehydrogenase 13.3
2-deoxyglucose-6-phosphate phosphatase 10.3
phosphoenolpyruvate carboxykinase 10.2
phosphoenolpyruvate carboxykinase 10.2
amylo-1,6-glucosidase 10.2
phosphoenolpyruvate carboxykinase 10.1
glucokinase 9.9
EC 1.1.1.47 9.3
fructose 1,6-bisphosphatase 9.2
triokinase 9.2
beta-glycerophosphatase 9.2
pyruvate carboxylase 9.1
glucose-1-phosphatase 9.0
hexokinase 9.0
EC 2.4.1.11 8.8
glycogen synthase phosphatase 8.7
citrate cleavage enzyme 8.6
5'-nucleotidase 8.6
GDPase 8.5
phosphorylase 8.5
palmitoyl-CoA hydrolase 8.3
tyrosine aminotransferase 8.3
succinic dehydrogenase 8.3
ketohexokinase 8.2
pyruvate kinase 8.1
nucleotidase 8.1
glucose-6-phosphate dehydrogenase 8.1
beta-hydroxybutyrate dehydrogenase 8.1
EC 1.1.1.39 8.0
ADPase 7.9
phosphofructokinase 7.7
sorbitol dehydrogenase 7.6
mutarotase 7.6
trimetaphosphatase 7.6
phosphoglucomutase 7.6
phosphoglucose isomerase 7.6
succinate dehydrogenase 7.5
6-phosphogluconate dehydrogenase 7.4
6-phosphogluconate dehydrogenase 7.4
more...
Compound
Linderane 13.3
Colchiceine 10.8
Skimmin 10.8
Colchiceine 10.8
Rubrofusarin 10.8
Rubrofusarin 10.5
2-Deoxy-D-galactose 10.3
2,5-Anhydro-D-mannitol 9.8
Isopulegol 9.8
Isopulegol 9.6
p-Synephrine 9.4
glucose-6-phosphate 9.3
H3AsO4 9.2
Phosphorylase a 8.9
Fraxetin 8.9
Menthone 8.8
p-Nitroanisole 8.7
Falcarindiol 8.5
carbamyl phosphate 8.5
Ethoxzolamide 8.4
Glucose 6-phosphate 8.4
GW 9662 8.2
Diethylcarbamazine citrate 8.1
Nafenopin 8.1
p-CA 8.0
Glycogen 8.0
EPA ethyl ester 8.0
NMOR 8.0
X 21 7.9
Bromelia 7.8
Umbelliferone 7.8
Ethylmorphine 7.7
Oxyresveratrol 7.7
Tetrahydrocurcumin 7.7
Betanin 7.7
Sulfoxide 7.7
Myricitrin 7.7
Samorin 7.6
Brazilin 7.6
Benzphetamine 7.6
more...