Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
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Human Gene/Protein
Hepatic nuclear factor 4 alpha 13.3
glucose-6-phosphatase 13.3
serum/glucocorticoid regulated kinase 2 13.3
GSD1a 12.3
glucose-6-phosphate transporter 12.2
G6PT 12.1
G6PC3 11.9
Glucose-6-phosphatase 11.9
SLC37A4 11.8
NPT3 11.8
G6Pase 11.7
SPX3 11.5
SLC37A2 11.3
phosphoenolpyruvate carboxykinase 1 11.1
ATP6V1D 11.0
G6F 11.0
fructose-bisphosphatase 10.9
TCDD-inducible poly(ADP-ribose) polymerase 10.8
phosphoenolpyruvate carboxykinase 10.7
dihydrolipoamide S-succinyltransferase 10.5
pyruvate kinase L 10.5
fructose-1,6-bisphosphatase 10.4
PEPCK-M 10.4
islet-specific glucose-6-phosphatase catalytic subunit-related protein 10.4
CRHSP-24 10.3
NPT4 10.3
Succinic dehydrogenase 10.3
phosphoinositide-3-kinase, catalytic, alpha polypeptide 10.2
liver glycogen synthase 10.2
B4GALT3 10.0
PEPCK-C 10.0
CL-6 9.9
glucokinase 9.9
1-acylglycerol-3-phosphate O-acyltransferase 2 9.9
phosphorylase, glycogen 9.9
PEPCK 9.9
SLC37A1 9.8
ZHX3 9.8
ZFP91 9.8
liver glycogen phosphorylase 9.7
PCK1 9.7
ACSS3 9.6
Phosphomonoesterase 9.6
S171 9.6
fructose-1,6-bisphosphatase 1 9.6
PYGL 9.6
GSD 9.4
ARSC 9.4
FBP2 9.4
Malic dehydrogenase 9.4
glycogen phosphorylase 9.3
phosphoenolpyruvate carboxykinase 2 9.3
GAAT 9.3
MDR/TAP 9.3
GlcNAc kinase 9.3
NADPH2 9.2
pyruvate carboxylase 9.1
semaphorin E 9.1
DDF1 9.1
HLC-1 9.0
GSD IX 9.0
hexokinase 9.0
FAP1 8.9
liver phosphofructokinase 8.9
very long-chain acyl-CoA synthetase 8.9
alkaline phosphodiesterase I 8.8
Solt 8.8
fetuin B 8.8
PCPH 8.8
Lysosomal acid phosphatase 8.8
carbamoylphosphate synthetase I 8.8
UGDH 8.8
PHKG2 8.8
serine dehydratase 8.7
HIG1 8.7
glucose-6-phosphate 1-dehydrogenase 8.7
Hepatocyte nuclear factor 6 8.7
glycogen synthase 8.7
carnitine palmitoyltransferase 1A 8.6
BDH2 8.6
BGR 8.6
NR1F1 8.6
Phosphorylase 8.6
5'-nucleotidase 8.6
cAMP responsive element binding protein 1 8.5
succinate dehydrogenase flavoprotein subunit 8.5
carbohydrate response element binding protein 8.5
ELK4 8.5
aquaporin 9 8.4
5-methyltetrahydrofolate-homocysteine methyltransferase 8.4
forkhead box A2 8.4
Glucokinase 8.4
fructose 1,6-bisphosphatase 8.4
glucose-6-phosphate dehydrogenase 8.4
serine/threonine kinase 2 8.3
DYRK1B 8.3
ZPI 8.3
PCK2 8.3
mitochondrial glycerol-3-phosphate dehydrogenase 8.3
G6PD protein 8.2
flotillin 2 8.2
adenosine triphosphatase 8.2
PPP1R3B 8.2
UDPase 8.2
guanosine monophosphate reductase 8.2
D-fructose-1,6-bisphosphate 1-phosphohydrolase 8.2
FBPase 8.1
COX4I2 8.1
AMPD2 8.1
pyrophosphatase 8.1
pyruvate kinase 8.1
hepatocyte nuclear factor 1 alpha 8.1
betaine homocysteine methyltransferase 8.1
Acylphosphatase 8.1
Glucosamine-6-phosphate synthase 8.1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 8.1
glucose transporter 4 8.0
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 8.0
palmitoyl-CoA hydrolase 8.0
E2DH 8.0
mPR 8.0
CAMKK2 7.9
FBP1 7.9
gamma-glutamyl transpeptidase 7.9
LRP130 7.9
3-hydroxybutyrate dehydrogenase 7.9
SLC2A5 7.8
gamma-glutamyltranspeptidase 7.8
NADP-malic enzyme 7.8
fructose transporter 7.8
GLUT2 7.8
NLRP10 7.8
phenylalanine 4-monooxygenase 7.8
PFK-1 7.8
PKL 7.8
insulin receptor substrate-2 7.8
6-phosphofructokinase 7.8
Malic enzyme 7.8
SLC2A2 7.8
NADH cytochrome b5 reductase 7.8
phosphofructokinase 7.7
sorbitol dehydrogenase 7.7
glycerokinase 7.7
multispanning membrane protein 7.7
lactate dehydrogenase-A 7.7
fructokinase 7.7
forkhead protein 7.7
forkhead transcription factor 7.6
IRS-2 7.6
GLUT-2 7.6
oncostatin M receptor 7.6
Max protein 7.6
Na+,K+ ATPase 7.6
isocitric dehydrogenase 7.5
PFK2 7.5
NOX3 7.5
phosphofructokinase 1 7.5
p46 7.5
GLUT12 7.5
GLUT5 7.5
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Disease
GSD I 12.1
Essential fructosuria 11.3
Glycogen storage disease type Ib 11.3
Hepatic glycogenosis 11.2
GSD 10.9
GSD 10.7
glycogen storage disease 10.5
Fanconi-like syndrome 10.2
Hers 10.0
fructose-1,6-diphosphatase deficiency 9.9
GSD IX 9.2
Hepatic impairment 8.7
Fasting hypoglycemia 8.6
disorders of carbohydrate metabolism 8.5
Extrahepatic cholestasis 7.9
porcine stress syndrome 7.5
hepatic adenoma 7.5
severe congenital neutropenia 7.3
Hepatocarcinogenesis 7.3
Tauri 7.1
Farber 7.0
Forbes 6.8
Oral ulcers 6.6
Klebs 6.6
diabetic hyperglycemia 6.5
hyperuricemia 6.4
favism 6.3
MODY3 6.3
Hepatic necrosis 6.2
hypoglycemia 6.2
hyperglycemia 6.2
xanthomatosis 6.1
postmaturity 6.1
HCA 6.0
metabolic disorder 6.0
AIN 6.0
enzyme deficiency 5.9
lactic acidosis 5.8
hereditary fructose intolerance 5.7
hyperinsulinemia 5.7
MODY 5.6
Vidal 5.6
HCC 5.6
vascular dilation 5.6
Reye's syndrome 5.6
moderate obesity 5.5
glucose intolerance 5.5
choline deficiency 5.5
hepatic porphyria 5.4
chronic cystitis 5.4
Autosomal recessive polycystic kidney disease 5.3
immune disorder 5.3
HBD 5.3
hyperlipidemia 5.1
beryllium disease 5.1
Canavan 5.1
vitamin C deficiency 5.0
Copper deficiency 5.0
hepatic neoplasm 4.9
neutropenia 4.8
fatty liver 4.8
methemoglobinemia 4.8
type 2 diabetes 4.7
Hailey-Hailey disease 4.7
Choroid 4.7
Choroid 4.7
ABO incompatibility 4.7
ketosis 4.7
Plasmodium vivax malaria 4.7
kwashiorkor 4.6
Schistosoma mansoni infection 4.6
Allergic bronchopulmonary aspergillosis 4.6
ASAT 4.6
marasmus 4.5
neonatal jaundice 4.5
vitamin E deficiency 4.5
chemical carcinogenesis 4.5
clonorchiasis 4.5
collagen disease 4.5
tophi 4.4
hepatocellular carcinoma 4.4
yaws 4.3
Mendelian disorders 4.3
hypercortisolemia 4.3
collagen disease 4.2
phosphaturia 4.2
failure to thrive 4.2
FAS 4.2
McArdle's disease 4.1
FBS 4.1
alcoholic fatty liver 4.1
kidney tumor 4.1
tyrosinemia 4.1
Adenovirus 4.0
wasting syndrome 4.0
endocrine disorder 4.0
Stomach 4.0
Stomach 4.0
Stomach 4.0
kernicterus 3.9
scurvy 3.9
neoplastic transformation 3.9
Stomach 3.9
HEP 3.9
diabetes 3.8
PCS 3.8
Chronic infection 3.8
Leigh syndrome 3.8
BCH 3.8
gout 3.8
Hepatotoxicity 3.8
Hyperplasia 3.7
Neoplasms 3.7
sudden infant death syndrome 3.7
galactosemia 3.7
siderosis 3.7
Fanconi syndrome 3.6
Lesch-Nyhan syndrome 3.6
primary pulmonary hypertension 3.6
DM2 3.6
hyperphagia 3.6
magnesium deficiency 3.6
PSP 3.5
Malignant transformation 3.5
thyrotoxicosis 3.5
liver cancer 3.5
Chronic hepatitis C 3.5
hormone deficiency 3.5
hyperoxaluria 3.5
Placenta 3.5
insulinoma 3.5
dyslipidemia 3.5
HPC 3.5
adrenal hyperplasia 3.5
carcinogenesis 3.4
adenoma 3.4
Rous sarcoma 3.4
delayed puberty 3.3
Testis 3.3
Testis 3.3
LBD 3.3
GSH 3.3
overnutrition 3.3
AMD 3.3
ALD 3.2
metabolic syndrome 3.2
NOD 3.2
Cirrhosis 3.2
Schistosoma mansoni 3.1
type 1 diabetes 3.1
thiamine deficiency 3.1
LTD 3.1
Wilson's disease 3.1
tubular necrosis 3.1
Krabbe disease 3.0
asbestosis 3.0
megaloblastic anemia 3.0
metachromatic leukodystrophy 3.0
Hymenolepis 3.0
G6PD deficiency 3.0
more...
Symptom
hepatomegaly 6.7
bradypnea 5.7
Cushingoid 5.6
Cushingoid 5.5
Decreased activity 5.3
autodigestion 5.0
polydipsia 4.2
ketonuria 4.2
polyuria 4.1
starvation 4.0
emaciation 3.3
menopausal symptoms 2.7
lethargy 2.4
acute stress 2.2
hypotonia 1.8
splenomegaly 1.7
anorexia 1.6
hepatosplenomegaly 1.2
exhaustion 1.2
cachexia 0.9
hunger 0.9
hypothermia 0.8
acidity 0.4
weakness 0.1
constipation 0.0
Ill -0.1
diarrhea -0.2
ataxia -0.6
anesthesia -0.8
respiratory distress -0.9
overweight -1.4
collapse -1.5
abdominal pain -1.6
vomiting -1.6
seizures -2.0
pain -4.7
Drug
Phenobarbital sodium 9.2
Hetrazan 8.8
Pegaspargase 8.2
Iron dextran 7.8
1-Deoxynojirimycin 7.7
Insulin lispro 7.6
Esculin 7.3
Tiopronin 7.2
Pyridoxamine 7.1
Ciprofibrate 7.0
Fructose 6.5
Corn oil 6.1
Nitazoxanide 6.0
Fenbendazole 6.0
Monosodium glutamate 6.0
Pentostam 6.0
CrCl3 5.8
Glucagon 5.8
Carbenoxolone 5.8
Swertia 5.4
Asparaginase 5.3
Pyridoxal 5.3
Troglitazone 5.3
Rosiglitazone 5.3
Bezafibrate 5.2
Fraction 5.2
Palmitoyl 5.1
Myricetin 5.1
NADH 4.8
Dextrose 4.7
beta-Galactosidase 4.6
Liraglutide 4.6
Glycerol 4.5
ISP 4.4
Emodin 4.4
AmBisome 4.3
Cellulase 4.3
Orphan 4.3
Clofibrate 4.2
Emodin 4.2
Metrizamide 4.1
Dasatinib 4.1
Vitamin B 4.0
Pronase 4.0
Tocopherol 3.9
Secretin 3.8
Vitamin E 3.7
Portal 3.6
Adenosine triphosphate 3.5
DEX 3.5
vitamin E 3.4
Sodium nitroprusside 3.4
Growth hormone 3.4
Growth hormone 3.3
Galactose 3.3
PCB 3.3
NAG 3.3
MRC 3.2
Albumin 3.1
Aloe 3.1
ascorbate 3.1
CoCl2 3.1
CoCl2 3.1
Honey 3.0
Glycyrrhiza 2.9
Amiloride 2.8
balanced salt solution 2.7
Ranitidine 2.7
Acacia 2.7
Ethanol 2.7
Ginseng 2.7
Glutathione 2.5
Amiloride 2.5
lactose 2.5
niacin 2.5
Itraconazole 2.4
ADR 2.3
CaCl2 2.3
CaCl2 2.3
CaCl2 2.2
Paraffin 2.2
L-tyrosine 2.1
TAT 2.1
pyridoxal phosphate 2.0
G-CSF 2.0
Alanine 1.9
Ringer's solution 1.9
ADM 1.7
Atropine 1.6
Retinoic acid 1.6
HCH 1.6
Kenyan 1.6
EPA 1.5
ROS 1.4
p75 1.4
EE2 1.4
Leaf 1.3
lysine 1.2
Adriamycin 1.2
citric acid 1.1
Gel 1.1
CTX 1.0
ICI 0.9
Histamine 0.9
Nephron 0.8
Mutagen 0.8
Indomethacin 0.7
PTH 0.6
DNase I 0.3
ABC 0.2
Nephron -0.2
IFN-gamma -0.5
CSF -0.6
caffeine -1.1
Dial -1.6
Enzyme
glucose-6-phosphatase 13.3
glycerin-3-phosphate dehydrogenase 13.3
2-deoxyglucose-6-phosphate phosphatase 10.3
phosphoenolpyruvate carboxykinase 10.2
phosphoenolpyruvate carboxykinase 10.2
amylo-1,6-glucosidase 10.2
phosphoenolpyruvate carboxykinase 10.1
glucokinase 9.9
EC 1.1.1.47 9.3
fructose 1,6-bisphosphatase 9.2
triokinase 9.2
beta-glycerophosphatase 9.2
pyruvate carboxylase 9.1
glucose-1-phosphatase 9.0
hexokinase 9.0
EC 2.4.1.11 8.8
glycogen synthase phosphatase 8.7
citrate cleavage enzyme 8.6
5'-nucleotidase 8.6
GDPase 8.5
phosphorylase 8.5
palmitoyl-CoA hydrolase 8.3
tyrosine aminotransferase 8.3
succinic dehydrogenase 8.3
ketohexokinase 8.2
pyruvate kinase 8.1
nucleotidase 8.1
glucose-6-phosphate dehydrogenase 8.1
beta-hydroxybutyrate dehydrogenase 8.1
EC 1.1.1.39 8.0
ADPase 7.9
phosphofructokinase 7.7
sorbitol dehydrogenase 7.6
mutarotase 7.6
trimetaphosphatase 7.6
phosphoglucomutase 7.6
phosphoglucose isomerase 7.6
succinate dehydrogenase 7.5
6-phosphogluconate dehydrogenase 7.4
6-phosphogluconate dehydrogenase 7.4
EC 2.7.7.9 7.4
fructokinase 7.4
carnosinase 7.4
CPR 7.3
tripeptidase 7.3
acid phosphatase 7.3
chloroperoxidase 7.2
acetylesterase 7.2
glutathione-insulin transhydrogenase 7.2
dihydrolipoamide succinyltransferase 7.2
aldolase 7.1
gamma-glutamyl transpeptidase 7.1
glutamic dehydrogenase 7.1
adamalysin 7.1
glyoxylate reductase 7.1
glyoxylate reductase 7.0
diaphorase 6.9
gluconokinase 6.9
gluconate dehydrogenase 6.9
pyruvate dehydrogenase phosphatase 6.9
p-nitrophenylphosphatase 6.9
fructose-2,6-bisphosphatase 6.8
EC 2.6.1.16 6.8
CYP8B1 6.8
pullulanase 6.8
isoamylase 6.8
AMP-activated kinase 6.8
phosphorylase kinase 6.7
phosphatidylinositol-4,5-bisphosphate 3-kinase 6.7
triphosphatase 6.7
glycerophosphate acyltransferase 6.6
phosphatidate phosphatase 6.6
glutamate dehydrogenase 6.6
glutamate dehydrogenase 6.6
glutamate dehydrogenase 6.6
DAP II 6.6
acetyl-CoA carboxylase 6.5
ribose-5-phosphate isomerase 6.5
polyphosphatase 6.5
phosphofructokinase 1 6.5
HMG-CoA synthase 6.4
transglucosylase 6.4
malate dehydrogenase 6.4
ornithine transcarbamylase 6.4
Mg2+-ATPase 6.4
isocitrate dehydrogenase 6.4
transpeptidase 6.3
NADH-cytochrome b5 reductase 6.3
EC 3.6.1.1 6.2
isocitrate dehydrogenase 6.2
prolinase 6.2
phosphoenolpyruvate carboxylase 6.2
diacylglycerol acyltransferase 6.1
EPT 6.1
leucine aminopeptidase 6.1
D-amino-acid oxidase 6.1
demethylase 6.1
carbamoylphosphate synthetase 6.1
fatty-acid synthase 6.1
betaine-homocysteine methyltransferase 6.0
lecithin:retinol acyltransferase 6.0
UDP-glucuronosyltransferase 6.0
6-phosphofructo-2-kinase 6.0
NMT 6.0
PDH 5.9
propionyl-CoA carboxylase 5.9
AMP-activated protein kinase 5.9
propionyl-CoA carboxylase 5.9
xylulokinase 5.9
glycolate oxidase 5.8
alanine aminopeptidase 5.8
glycerol kinase 5.8
diaphorase 5.8
11beta-hydroxysteroid dehydrogenase 5.8
sucrase 5.8
nucleotide pyrophosphatase 5.8
NADPH-diaphorase 5.8
CPT 5.8
acyl-CoA oxidase 5.7
transaldolase 5.7
uricase 5.7
glucose dehydrogenase 5.7
EC 1.1.1.40 5.6
glyceraldehyde-3-phosphate dehydrogenase 5.6
glyceraldehyde-3-phosphate dehydrogenase 5.6
branching enzyme 5.6
lactate dehydrogenase 5.6
alpha-glucosidase 5.6
4-epimerase 5.6
glyceraldehyde-3-phosphate dehydrogenase 5.6
beta-1,4-galactosyltransferase 5.6
tryptophan 2,3-dioxygenase 5.6
NAD+ oxidoreductase 5.6
alkaline phosphatase 5.6
glycerol-3-phosphate dehydrogenase 5.6
dihydrodiol dehydrogenase 5.5
3-hydroxyacyl-CoA dehydrogenase 5.5
glycerol-3-phosphate dehydrogenase 5.5
3-hydroxyacyl-CoA dehydrogenase 5.5
lactic acid dehydrogenase 5.5
inositol 3-kinase 5.5
acylphosphatase 5.5
cytochrome oxidase 5.5
arginase 5.5
histidase 5.5
aryl hydrocarbon hydroxylase 5.5
glyceraldehyde-3-phosphate dehydrogenase 5.5
lactase 5.4
lactic acid dehydrogenase 5.4
glutaminase 5.4
PRPP synthetase 5.4
PPH 5.4
alpha-mannosidase 5.4
CPS 5.4
acyl-CoA synthetase 5.3
lysophosphatidylcholine acyltransferase 5.3
MDH 5.3
pyruvate dehydrogenase 5.3
xylitol dehydrogenase 5.3
S-adenosyl-L-homocysteine hydrolase 5.2
more...
Compound
Linderane 13.3
Colchiceine 10.8
Skimmin 10.8
Colchiceine 10.8
Rubrofusarin 10.8
Rubrofusarin 10.5
2-Deoxy-D-galactose 10.3
Isopulegol 9.8
2,5-Anhydro-D-mannitol 9.8
Isopulegol 9.6
p-Synephrine 9.4
glucose-6-phosphate 9.3
H3AsO4 9.2
Phosphorylase a 8.9
Fraxetin 8.9
Menthone 8.8
p-Nitroanisole 8.7
Falcarindiol 8.5
carbamyl phosphate 8.5
Ethoxzolamide 8.4
Glucose 6-phosphate 8.4
GW 9662 8.2
Diethylcarbamazine citrate 8.1
Nafenopin 8.1
p-CA 8.0
Glycogen 8.0
NMOR 8.0
EPA ethyl ester 8.0
X 21 7.9
Bromelia 7.8
Umbelliferone 7.8
Ethylmorphine 7.7
Oxyresveratrol 7.7
Sulfoxide 7.7
Betanin 7.7
Myricitrin 7.7
Tetrahydrocurcumin 7.7
Samorin 7.6
Brazilin 7.6
Benzphetamine 7.6
Telepaque 7.6
Embelin 7.5
Eupatilin 7.5
Gadolinium chloride 7.5
fructose-1-phosphate 7.4
Hesperidin 7.4
DPPD 7.4
F6P 7.4
F6P 7.4
Guggulsterone 7.3
C6F6 7.3
Esculin 7.3
Synephrine 7.2
Acephate 7.2
Deoxycholic acid 7.2
WY-14,643 7.2
Phloroglucinol 7.2
thieno[2,3-b]pyridine 7.2
DDMU 7.2
CONV 7.2
9(10H)-anthracenone 7.1
cyclohexanecarboxylic acid 7.1
cyclohexanecarboxylic acid 7.1
cyclohexanecarboxylic acid 7.1
cyclohexanecarboxylic acid 7.1
Chlordecone 7.1
Pyridoxamine 7.1
X 13 7.1
cyclohexanecarboxylic acid 7.1
Phloroglucinol 7.1
alloxan 7.1
Imperatorin 7.1
D-xylulose-5-phosphate 7.0
2-decenoic acid 7.0
Triamcinolone 7.0
D-Galactosamine 7.0
Medroxyprogesterone 7.0
Trigonelline 6.9
propionyl-coenzyme A 6.9
CCl4 6.9
Beryllium 6.9
Diosmin 6.9
fructose-6-P 6.9
Cephaloridine 6.8
AMPD 6.8
Tyrosol 6.8
Sodium deoxycholate 6.7
Glycerol-3-phosphate 6.7
dihydroxyacetone-phosphate 6.7
arsenic acid 6.7
arsenic acid 6.7
arsenic acid 6.7
arsenic acid 6.6
Esculin 6.6
Phlorizin 6.6
HSM 6.6
mannitol-1-phosphate 6.6
Scopoletin 6.6
STZ 6.5
glutaryl-CoA 6.5
Plumbagin 6.5
Bisphenol S 6.5
Puromycin 6.5
Asiatic acid 6.5
AICAR 6.5
Fructose 6.5
PPi 6.4
Triton WR-1339 6.4
Ursolic acid 6.3
Digitonin 6.3
2,6-DNT 6.3
Sodium orthovanadate 6.3
PIPES 6.2
PIPES 6.2
PIPES 6.2
HCA 6.2
Iodoacetamide 6.2
Tiron 6.2
AAF 6.2
PDH 6.2
Veronal 6.2
Hexobarbital 6.1
Esculetin 6.1
Naringin 6.1
Lupeol 6.1
Geniposide 6.1
DEN 6.0
Eugenol 6.0
CPIB 6.0
AICAR 6.0
Eugenol 6.0
1,3-butanediol 5.9
6-phosphogluconate 5.9
hexose 5.9
hexose 5.9
hexose 5.9
Dihydroxyacetone 5.9
VO4 5.9
2,4,5-trichlorophenol 5.9
1,3-butanediol 5.8
pentose 5.8
pentose 5.8
Monocrotaline 5.8
dioctyl phthalate 5.8
Glucagon 5.8
Barbiturate 5.8
pentose 5.8
inositol 1,4-bisphosphate 5.7
Aminopyrine 5.7
pentose 5.7
PTU 5.7
Ornithine 5.7
glucose 5.6
Diosgenin 5.6
isocitrate 5.6
Morin 5.6
Pyruvate kinase 5.6
Diallyl 5.6
Potassium chloride 5.5
Mannose 5.5
more...