Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
glucose-6-phosphatase 3059
insulin 721
phosphoenolpyruvate carboxykinase 479
microsomal 421
endoplasmic reticulum 325
glucokinase 272
hexokinase 254
alkaline phosphatase 218
Sep 204
glucose-6-phosphate dehydrogenase 199
acid phosphatase 190
Mol 172
G6Pase 166
pyruvate kinase 138
glycogen phosphorylase 134
glucagon 131
fructose-1,6-bisphosphatase 127
lactate dehydrogenase 121
ATPase 121
GSD 117
phosphatase 111
5'-nucleotidase 111
glycogen synthase 98
adenosine triphosphatase 97
catalase 93
ATP 87
cytochrome P-450 83
albumin 80
Glucose-6-phosphatase 79
NADPH 79
pyruvate carboxylase 76
phosphofructokinase 69
hemoglobin 67
glucose transporter 67
superoxide dismutase 65
fatty acid synthase 65
glucose-6-phosphate transporter 62
gamma-glutamyl transpeptidase 61
AMP-activated protein kinase 60
aspartate aminotransferase 58
NADH 57
reductase 53
PEPCK 51
peroxisome proliferator-activated receptor 50
protein kinase B 50
insulin receptor 48
leptin 46
AMP 44
pyrophosphatase 43
IRS-1 42
membrane-bound 41
glutamate dehydrogenase 40
esterase 40
rhabdomyosarcoma 39
PGC 37
alanine aminotransferase 37
TAT 37
GSH 35
alpha-fetoprotein 34
cytochrome 33
cytochrome P450 32
malate dehydrogenase 32
glutathione peroxidase 30
glucocorticoid receptor 29
gamma-glutamyltranspeptidase 29
AKT 28
beta-glucuronidase 27
lipase 27
G6PC3 26
adenylate cyclase 26
glycolytic enzyme 26
acetyl-CoA carboxylase 25
NAD 25
adiponectin 24
STZ 24
glucose transporter 4 24
amylase 24
6-phosphogluconate dehydrogenase 24
isocitrate dehydrogenase 23
peroxisome proliferator-activated receptor gamma 22
brush border 22
TNF 21
glyceraldehyde-3-phosphate dehydrogenase 21
AMPK 21
peroxidase 21
sorbitol dehydrogenase 20
HDL 20
GLUT2 20
A-I 20
cytochrome c oxidase 19
glucosidase 19
histone 19
proximal tubule 19
galactosyltransferase 18
gut 18
polypeptide 18
cytochrome b5 17
collagenase 17
IRS-2 17
gamma-glutamyltransferase 17
PCK1 16
glutamate pyruvate transaminase 16
GLUT4 16
islet-specific glucose-6-phosphatase catalytic subunit-related protein 16
GSK 16
NADP 16
phosphatidylinositol 3-kinase 16
NMR 16
collagen 16
growth hormone 16
mTOR 15
carnitine palmitoyltransferase 15
serum protein 15
cytokine 15
phosphoenolpyruvate carboxykinase 1 15
glycoprotein 15
ADP 15
epididymal 15
sterol regulatory element-binding protein 15
diaphorase 14
Glucokinase 14
fructose-bisphosphatase 14
cytochrome c 14
HCC 14
glutathione S-transferase 14
cAMP-response element 13
Alkaline phosphatase 13
tumor necrosis factor 13
forkhead transcription factor 13
CREB 13
Acid phosphatase 13
LDH 13
insulin-like growth factor 13
thyroid hormone 12
IL-6 12
glutathione reductase 12
serum albumin 12
insulin receptor substrate 12
PI3K 12
acetylcholinesterase 12
PPAR 12
xenobiotic 12
carp 12
glucosamine 12
pyruvate dehydrogenase 12
phosphoenolpyruvate carboxylase 12
interleukin-6 11
leucine aminopeptidase 11
liver glycogen synthase 11
fructose 1,6-bisphosphatase 11
thymus 11
FDG 11
lipoprotein lipase 11
phosphoglucose isomerase 11
inorganic pyrophosphatase 10
PEPCK-C 10
SLC37A4 10
GTP 10
galactosamine 10
SOD 10
more...
Disease
diabetes 383
hyperglycemia 205
glycogen storage disease 192
hypoglycemia 148
type 2 diabetes 148
hepatocellular carcinoma 143
GSD 117
GSD 117
cancer 114
GSD I 109
tumor 103
obesity 91
carcinogenesis 68
hyperinsulinemia 54
hyperlipidemia 53
glucose intolerance 52
neutropenia 47
fatty liver 37
GSH 36
cirrhosis 31
metabolic disorder 31
hyperuricemia 31
adenoma 22
lactic acidosis 22
metabolic syndrome 22
carcinoma 21
depression 19
type 1 diabetes 17
cold 17
liver cancer 17
dyslipidemia 15
liver disease 15
hypertension 15
HCC 14
tumorigenesis 14
malnutrition 14
hepatitis 13
renal disease 11
hypercholesterolemia 10
AIN 10
ischemia 9
inflammatory bowel disease 8
Alzheimer's disease 8
Glycogen storage disease type Ib 8
Farber 8
acute renal failure 8
renal failure 8
enzyme deficiency 8
uterus 8
gout 7
sepsis 7
atherosclerosis 7
hyperphagia 7
severe congenital neutropenia 7
proteinuria 7
FAS 7
neoplastic transformation 7
SDS 6
hyperthyroidism 6
hypothyroidism 6
Schistosoma mansoni 6
NOD 6
HCA 6
adenocarcinoma 6
failure to thrive 6
hepatitis B 6
cholestasis 6
alcoholic fatty liver 6
sepsis 6
Placenta 6
West 6
ketosis 5
lymphoma 5
malaria 5
Hers 5
Adenovirus 5
fits 5
pulmonary hypertension 5
cholera 5
schistosomiasis 5
hepatic adenoma 5
sudden infant death syndrome 5
epididymis 5
osteoporosis 4
thrombocytopenia 4
Reye's syndrome 4
tumor progression 4
sarcoma 4
thyrotoxicosis 4
SEM 4
diabetic nephropathy 4
anemia 4
tumor growth 4
worms 4
disorders of carbohydrate metabolism 4
Forbes 4
cardiovascular disease 4
insulinoma 4
peritonitis 3
immunodeficiency 3
dehydration 3
cytomegalovirus 3
neuroblastoma 3
nephritis 3
gestational diabetes mellitus 3
arthritis 3
chronic hepatitis 3
amyloidosis 3
FBS 3
preeclampsia 3
methemoglobinemia 3
viral hepatitis 3
chemical carcinogenesis 3
Rous sarcoma 3
iron overload 3
glomerulosclerosis 3
fibrosarcoma 2
hypogonadism 2
stroke 2
pancreatitis 2
malabsorption 2
liver cancer 2
fructose-1,6-diphosphatase deficiency 2
primary pulmonary hypertension 2
ALD 2
Schistosoma mansoni infection 2
endocrine disorder 2
Fanconi-like syndrome 2
portal hypertension 2
microalbuminuria 2
mole 2
gastric ulcer 2
liver fibrosis 2
rhabdomyosarcoma 2
Brown 2
addiction 2
herpes simplex 2
stomatitis 2
parasitic disease 2
Hepatocarcinogenesis 2
chronic renal failure 2
Leigh syndrome 2
mole 2
lung cancer 2
metastases 2
immaturity 2
tumor initiation 2
Wilson's disease 2
Fanconi 2
Fanconi syndrome 2
dysplasia 2
cerebral ischemia 2
immune disorder 2
meninges 2
gallstones 2
xanthomatosis 2
leprosy 2
renal insufficiency 2
genetic disorder 2
acute hepatitis 2
more...
Symptom
hepatomegaly 57
starvation 38
anesthesia 6
diarrhea 5
polyuria 5
weakness 4
polydipsia 4
anorexia 4
splenomegaly 3
exhaustion 3
lethargy 3
hypothermia 3
seizures 2
Decreased activity 2
hypotonia 2
acute stress 2
acidity 2
cachexia 1
Ill 1
hunger 1
Cushingoid 1
constipation 1
collapse 1
bradypnea 1
respiratory distress 1
overweight 1
ataxia 1
Cushingoid 1
ketonuria 1
pain 1
hepatosplenomegaly 1
autodigestion 1
vomiting 1
menopausal symptoms 1
abdominal pain 1
emaciation 1
Drug
NADH 61
Glucagon 20
ascorbate 19
vitamin E 18
Fructose 17
lysine 13
lactose 9
Fraction 9
Ethanol 6
Portal 5
ROS 5
Glycerol 5
Leaf 5
Vitamin E 4
Albumin 4
PCB 4
Gel 3
CaCl2 3
CaCl2 3
Growth hormone 3
Glutathione 3
Rosiglitazone 3
Growth hormone 3
CaCl2 3
Nephron 3
MRC 3
EE2 2
Troglitazone 2
Vitamin B 2
IFN-gamma 2
NAG 2
CSF 2
niacin 2
Pronase 2
CTX 2
EPA 2
citric acid 2
G-CSF 2
1-Deoxynojirimycin 1
Hetrazan 1
Sodium nitroprusside 1
CrCl3 1
Kenyan 1
DNase I 1
Asparaginase 1
ADR 1
Liraglutide 1
Orphan 1
Nitazoxanide 1
Histamine 1
Cellulase 1
Tiopronin 1
Clofibrate 1
ADM 1
Ranitidine 1
Dextrose 1
Secretin 1
L-tyrosine 1
Dasatinib 1
balanced salt solution 1
Alanine 1
Emodin 1
Tocopherol 1
AmBisome 1
Pegaspargase 1
Adriamycin 1
ICI 1
Acacia 1
p75 1
Monosodium glutamate 1
caffeine 1
TAT 1
Pentostam 1
Ringer's solution 1
Mutagen 1
Ciprofibrate 1
Paraffin 1
Atropine 1
ABC 1
ISP 1
Pyridoxal 1
Amiloride 1
Itraconazole 1
PTH 1
HCH 1
Amiloride 1
Glycyrrhiza 1
Insulin lispro 1
Galactose 1
Metrizamide 1
Honey 1
CoCl2 1
Nephron 1
Iron dextran 1
Retinoic acid 1
Fenbendazole 1
Phenobarbital sodium 1
Pyridoxamine 1
Ginseng 1
Indomethacin 1
pyridoxal phosphate 1
Bezafibrate 1
Emodin 1
CoCl2 1
Corn oil 1
Esculin 1
Adenosine triphosphate 1
Dial 1
Palmitoyl 1
Aloe 1
beta-Galactosidase 1
Swertia 1
Myricetin 1
DEX 1
Carbenoxolone 1
Enzyme
glucose-6-phosphatase 3081
phosphoenolpyruvate carboxykinase 507
phosphoenolpyruvate carboxykinase 485
phosphoenolpyruvate carboxykinase 482
glucokinase 272
hexokinase 255
ATPase 231
alkaline phosphatase 220
glucose-6-phosphate dehydrogenase 207
phosphorylase 199
acid phosphatase 191
succinate dehydrogenase 146
pyruvate kinase 142
lactate dehydrogenase 138
gamma-glutamyl transpeptidase 122
5'-nucleotidase 116
catalase 97
protein kinase 94
pyruvate carboxylase 81
CPR 80
alanine aminotransferase 76
AMP-activated protein kinase 76
phosphofructokinase 75
aspartate aminotransferase 73
superoxide dismutase 73
diaphorase 68
succinic dehydrogenase 52
aldolase 47
fructose 1,6-bisphosphatase 45
glutamate dehydrogenase 41
glutamate dehydrogenase 41
glutamate dehydrogenase 41
tyrosine aminotransferase 39
cytochrome oxidase 38
malate dehydrogenase 38
demethylase 36
adenylate cyclase 31
phosphoglucose isomerase 31
glutathione peroxidase 30
lipase 28
nucleotidase 28
acetylcholinesterase 27
peroxidase 27
acetyl-CoA carboxylase 26
isocitrate dehydrogenase 25
phosphoglucomutase 25
beta-glucuronidase 25
AMPK 25
isocitrate dehydrogenase 25
6-phosphogluconate dehydrogenase 24
CPT 24
glyceraldehyde-3-phosphate dehydrogenase 24
6-phosphogluconate dehydrogenase 24
glyceraldehyde-3-phosphate dehydrogenase 22
NADPH-diaphorase 21
glyceraldehyde-3-phosphate dehydrogenase 21
glyceraldehyde-3-phosphate dehydrogenase 21
glyceraldehyde-3-phosphate dehydrogenase 21
AMPK 21
sorbitol dehydrogenase 20
UDP-glucuronosyltransferase 20
alpha-glucosidase 20
glutathione S-transferase 18
monoamine oxidase 18
mitogen-activated protein kinase 18
collagenase 17
NQO1 17
phosphatidylinositol 3-kinase 16
GSK 16
arginase 16
RNase 15
triphosphatase 15
phosphodiesterase 15
pyruvate dehydrogenase 15
focal adhesion kinase 15
diaphorase 15
trypsin 15
ornithine transcarbamylase 14
cholinesterase 14
sucrase 13
NADPH oxidase 13
ADPase 13
pyruvate dehydrogenase 13
Mg2+-ATPase 12
CPT 12
phosphoenolpyruvate carboxylase 12
pyruvate dehydrogenase 12
invertase 12
glutathione reductase 12
lipoprotein lipase 11
xanthine oxidase 11
transpeptidase 11
protein kinase C 11
luciferase 11
leucine aminopeptidase 11
phosphoinositide 3-kinase 10
calcineurin 10
beta-hydroxybutyrate dehydrogenase 10
glutamine synthetase 10
AST 10
lactase 9
amylo-1,6-glucosidase 9
CPT 9
phosphorylase kinase 9
pullulanase 8
RNA polymerase 8
citrate synthase 8
glycerol-3-phosphate dehydrogenase 8
glycerol-3-phosphate dehydrogenase 8
isoamylase 8
glutaminase 8
hexosaminidase 7
phospholipase A2 7
11beta-hydroxysteroid dehydrogenase 7
RNase 7
phospholipase C 7
cholesterol acyltransferase 7
proteasome 7
NADPH oxidase 7
aldose reductase 7
beta-galactosidase 7
p-nitrophenylphosphatase 7
aryl hydrocarbon hydroxylase 7
diacylglycerol acyltransferase 6
chloroperoxidase 6
fructokinase 6
alpha-mannosidase 6
sulfatase 6
CD13 6
PDK1 6
uricase 6
AMP-activated kinase 5
acyl-CoA oxidase 5
alpha-amylase 5
chloramphenicol acetyltransferase 5
acyl-CoA synthetase 5
DNase 5
ERK 5
cathepsin D 5
glucose dehydrogenase 5
heme oxygenase 5
CPS 5
tryptophan 2,3-dioxygenase 4
caspase-3 4
chymotrypsin 4
transketolase 4
ACS 4
glycerol kinase 4
creatine kinase 4
complex I 4
reverse transcriptase 4
HMG-CoA synthase 4
EC 1.1.1.47 4
ceruloplasmin 4
pepsin 4
glucoamylase 4
beta-glucosidase 4
dipeptidyl peptidase IV 4
adenylate kinase 4
lysozyme 4
more...
Compound
glucose 1434
phosphate 326
glucose-6-phosphate 216
Dec 199
DNA 144
water 120
sodium 115
Clin 114
galactose 101
ATP 87
NADPH 81
NADPH 79
urea 78
Insulin 76
calcium 73
glycerol 64
cAMP 63
NADH 61
Glycogen 58
CCl4 57
alloxan 53
oxygen 52
alanine 49
AMP 49
creatinine 42
ethanol 39
nitrogen 39
hexose 39
GSH 38
GSH 38
nicotinamide 36
hexose 35
hexose 35
hexose 35
pentose 34
pentose 34
STZ 34
pentose 34
pentose 34
CoA 32
NAD 32
iron 29
aniline 28
arginine 26
glutamate 26
NAD 25
leucine 25
tyrosine 25
acetate 24
sulfate 24
serine 24
Triton X-100 24
EDTA 22
EDTA 22
glutamine 22
TNF 21
zinc 21
Glucagon 20
carbamyl phosphate 20
NADP 19
potassium 19
hydrogen 19
methionine 18
lysine 17
His 17
ADP 17
Fructose 17
Mg2+ 17
PPi 17
cadmium 16
salt 15
UDP 15
ADP 15
ADP 15
pyrene 14
GlcNAc 14
vanadium 14
uridine 14
ammonia 13
ammonium 13
nitrate 13
palmitic acid 12
Glucose 6-phosphate 12
chloroform 12
UDP-glucose 12
Lactate 12
2-oxoglutarate 11
copper 11
acetone 11
aflatoxin B1 11
cysteine 11
GTP 10
CO2 10
threonine 10
mercury 10
tryptophan 10
phosphorus 10
DHA 10
tryptophan 10
tryptophan 10
tryptophan 10
adenylate 10
palmitic acid 9
iodine 9
2-ethylhexyl 9
selenium 9
2-ethylhexyl 9
GPT 9
2-ethylhexyl 9
CPT 9
AICAR 9
AAF 9
nitric oxide 9
CPT 9
ornithine 8
acetyl-CoA 8
ornithine 8
Phe 8
isocitrate 8
ornithine 8
cobalt 8
ornithine 8
methanol 8
Cortisol 8
DEN 8
phenol 8
ornithine 8
Cholesterol 7
SDS 7
UDP-GlcNAc 7
Asp 7
Metformin 7
PDH 7
PAS 7
oxalate 7
Metformin 7
DEHP 7
aldehyde 7
noradrenaline 7
hexane 7
AICAR 7
Sucrose 6
isoleucine 6
Diabetol 6
acetic acid 6
Curcumin 6
UDP-galactose 6
pyridine 6
Adenosine 6
TCA 6
DMSO 6
chromium 6
palmitoyl-CoA 6
ALP 6
Lead 6
DAB 6
Diabetol 6
Ile 6
HgCl2 6
isoleucine 6
more...