Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.9 (
glucose-6-phosphatase
)
3,081
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Inactivation of both cytosolic 5'-nucleotidase and
ecto-5'-nucleotidase
by diethylpyrocarbonate indicated the presence of an essential histidyl residue which in the cytosolic enzyme was conclusively located at the active site. Inactivation by thiol reagents indicated the presence of an essential cysteinyl residue in both enzymes. The data suggest that both 5'-nucleotidases belong to a group of histidine phosphatases which also includes
glucose-6-phosphatase
and acid phosphatase. A working hypothesis for the catalytic mechanism of these enzymes is proposed.
...
PMID:Identification of histidyl and cysteinyl residues essential for catalysis by 5'-nucleotidase. 632 Dec 42
