Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.9 (
glucose-6-phosphatase
)
3,081
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of alcohol metabolism in
2-butanol
-induced potentiation of carbon tetrachloride (CCl4) hepatotoxicity was studied in rats. Animals were sacrificed at various times after the administration of
2-butanol
(2.2 ml/kg p.o.) for the determination of blood
2-butanol
and 2-butanone concentrations by gas chromatographic analysis.
2-butanol
exhibited an apparent elimination half-life of 2.5 hours. With the decline of
2-butanol
concentrations, there was a rise in 2-butanone blood concentrations with 43 mg/100 ml detected at 1 hour and a maximum of 105 mg/100 ml detected 4 hours after the administration of the alcohol. A 16-hour pretreatment with either
2-butanol
(2.2 ml/kg p.o.) or 2-butanone (1.87 ml/kg p.o.) markedly enhanced the hepatotoxic response of CCl4 (0.1 ml/kg i.p.) as measured by serum glutamic pyruvic transaminase activity, hepatic
glucose-6-phosphatase
activity and triglyceride content. The enhanced hepatotoxicity produced by
2-butanol
was not significantly different from that produced by 2-butanone. The potentiation of CCl4 hepatotoxicity by both agents was substantiated morphologically. The results indicate that 2-butanone production via the oxidation of
2-butanol
appears to contribute to the marked response of
2-butanol
.
...
PMID:The participation of 2-butanone in 2-butanol-induced potentiation of carbon tetrachloride hepatotoxicity. 125 93
