Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spermatogenically active testes of rat challenged by 100 mg/kg body weight of p- Chlorophenylalanine for 45 days displayed marked and drastic changes in the seminiferous epithelium. Degenerative changes followed by immense necrosis of germ cells lead to complete breakdown of seminiferous tubules. Leydig cells, however, remained unaffected histologically in the treated animals. Among the accessory sex organs, epididymis alone showed a marked decrease in its weight. A biochemical study in the drug treated rats revealed a significant accumulation of glycogen in the testes accompanied by increase in the activities of enzymes like the succinic dehydrogenase, glucose-6-phosphatase, ATP-ase and acid phosphatases. However, a marked decrease was noticed in the activities of enzymes like alkaline phosphatase, phosphohexose isomerase and lactate dehydrogenase. No significant change was found in the protein, DNA and RNA concentrations in the drug treated testes. The histological and biochemical changes induced in the testes by p-CPA suggest the deleterious effect of the drug on the seminiferous tubules of the testes.
 ...
PMID:Effect of para-chlorophenylalanine on male rats: histopathological and biochemical changes in the testes. 303 Sep 34

Ultrastructural and histochemical studies were performed on Wistar rats treated during 6 days with Cyclophosphamide 50 mg/kg/day or Lomustine 20 mg/kg/day. Changes in cerebellum after both drugs were similar. Most severe ultrastructural lesions were found in glia, mainly astroglia cells localized in perivascular area. Cytoplasm of these cells was on the large area devoid of organelles. Neurons were less affected but in Purkinje cells mild ultrastructural lesions were found. Increased activity of glucose-6-phosphatase and decreased of succinate dehydrogenase activity in these cells suggest that cytostatic treatment disturbed metabolism in the neurons.
 ...
PMID:Effect of alkylating drugs on rat cerebellum. 372 Oct 19