Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A single dose of calcitonin (CT) (70 mU MRC/100 g body weight) was administered in 50 and 90 days old male Wistar rats. In both ages CT determined a rise of Phosphorylase a and glucose-6-phosphatase activity as well as an increased calcium accumulation at the level of liver particulate glycogen. In the rats receiving CT glycemia increased and the liver glycogen content decreased. With the exception of liver glycogen the other metabolic parameters studied were modified at the two ages in the same manner under the influence of the same dose of CT.
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PMID:Effect of calcitonin on phosphorylase a and glucose-6-phosphatase activities in the hepatic particulate glycogen of rats. 303 11

The effect of calcitonin (CT) on calcium content and glucose-6-phosphatase activity in the hepatic microsomes of rats was investigated. A single sc administration of CT (80 MRC mU/100 g body weight) produced a significant increase in microsomal calcium content and a corresponding elevation of microsomal glucose-6-phosphatase activity. An appreciable effect of CT was observed at a dose of 20 MRC mU/100 g body weight. On the other hand, the removal of calcium by 10 mM EGTA washing of the microsomes caused a marked reduction of glucose-6-phosphatase activity raised by CT administration. The addition of calcium ion at the amount of 10(-2)-10(3) nmoles Ca2+ per mg protein in the microsomes produced a significant increase in glucose-6-phosphatase activity. The present results suggest that microsomal calcium increased by CT administration activates glucose-6-phosphatase in the hepatic microsomes of rats.
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PMID:Calcitonin increases calcium content and glucose-6-phosphatase activity in hepatic microsomes of rats. 630 33

The calmodulin dependency of calcitonin (CT) action on glucose-6-phosphatase and phosphyorylase alpha activities in the liver of rats was investigated. A single sc administration of CT (synthetic [A1,7] eel CT; 80 MRC mU/100 g body weight) produced significant increases in calcium content and glucose-6-phosphatase activity in the hepatic microsomes of intact and thyroparathyroidectomized rats. These increases in enzyme activity were significantly inhibited by W-7 (100 microM), with a concentration which showed maximal effect. However, this inhibition was less than 50% of the enzyme activity increased by CT administration. Meanwhile, CT produced significant increases in calcium content and phosphorylase alpha activity in the hepatic glycogen particles from intact rats. However, this increase in enzyme activity was not influenced significantly by W-7 (100 microM), suggesting that the calcium ion may directly activate the enzyme. These results suggest that the increase in microsomal glucose-6-phosphatase activity of rat liver mediated by cellular calcium following CT administration may partly depend on calmodulin.
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PMID:Calmodulin dependency of calcitonin action on glucose-6-phosphatase and phosphorylase alpha activities in the liver of rats. 631 94