Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of 1.8 mg/liter (LC50) of mercuric chloride exposure on the activities of alkaline phosphatase, acid phosphatase, glucose-6-phosphatase, amylase, pepsin, trypsin, tripeptidase glycyl-glycine dipeptidase and carnosinase has been examined in Channa punctatus. The three phosphatases have been inhibited in the liver but showed an increase in activity in the intestine and pyloric caeca. Amylase, pepsin and trypsin have also shown a slight increase in activity. There has been no significant alteration in the activites of the peptidases. The results show that mercury inhibits the activites of phosphatases in the liver but has no significant effect on the digestive enzymes within the experimental period of 96 hours.
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PMID:Effect of mercuric chloride on the digestive system of a teleost fish, Channa punctatus. 21 48

Alterations in the activities of alkaline phosphatase, acid phosphatase, glucose-6-phosphatase amylase, trypsin, pepsin, aminotripeptidase, glycylglycine dipeptidase and carnosinase due to exposure of Channa punctatus to a sublethal concentration (0.30 mg/L) of mercuric chloride by bath for 20 days have been studied in the different parts of the digestive system. Afall in the activities of the three phosphatases was recorded except for alkaline phosphatase which showed a slight elevation in activity in intestine and pyloric caeca. An increase in the activity of amylase and the two proteases was observed in all the portions of the digestive system. The three peptidases revealed a decrease in activity.
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PMID:The in vivo effect of mercuric chloride on some digestive enzymes of a fresh water teleost fish, Channa punctatus. 22 1

A procedure is described for the preparation of a membrane fraction enriched in basal-lateral plasma membranes from gastric mucosa. Gastric glands isolated from rabbit were employed as starting material, greatly reducing contamination from non-glandular cell types. The distribution of cellular components during the fractionation procedure was monitored with specific marker enzymes. (Na+ + K+)-ATPase, ouabain-sensitive K+-stimulated p-nitrophenyl-phosphatase and histamine-stimulated adenylate cyclase were used as markers for basal-lateral membranes. These three markers were similarly distributed during both differential and equilibrium density gradient centrifugation. The enriched membrane fraction contained more than 30% of the total initial activities of the three basal-lateral membrane markers which were purified better than 11-fold with respect to protein. (Na+ + K+)-ATPase activity was resolved from the activities of acid phosphatase, pepsin, Mg2+-ATPase, cytochrome c oxidase, NADPH-cytochrome c reductase, glucose-6-phosphatase, (K+ + H+)-ATPase, DNA and RNA.
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PMID:An enriched preparation of basal-lateral plasma membranes from gastric glandular cells. 626 84

In Wistar rats kept for 15, 30 and 60 days in a hypokinetic state in special cages, alteration of some gastrointestinal glands was studied by means of histochemical and electron microscopic methods. After 15-30 days of hypokinesia, a decrease was found in the muco-polysaccharide content of the submaxillary, gastric and duodenal glands. The intestinal goblet cells appeared vacuolated. The oxyntic cells, which secrete HCl, as well as the G antral cells, which secrete gastrin, were in an active state. The hypokinetic rats exhibited increased gastric secretion. The electron microscopic aspect of the principal cells corresponded to augmented pepsin secretion. The enterocytes showed an increase in their leucine aminopeptidase, acid phosphatase and glucose-6-phosphatase content. In the submucosa of the fundus of the stomach an accumulation of eosinophils was observed. These modifications were more striking after 15 than after 30 days, and disappeared after 60 days of hypokinesia. These morphological and functional changes may be explained by glucocorticoid hypersecretion corresponding to a stress reaction.
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PMID:The gastrointestinal tract in hypokinetic rats. 1200 6