Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In acute CCL4 intoxication of rats significantly increased activities of hepatic low-Km hexokinases, glucose-6-phosphate dehydrogenase, phosphofructokinase, aldolase A and pyruvate kinase M2 with concurrently decreased activities of glucokinase, glucose-6-phosphatase, fructose-1,6-diphosphatase, aldolase B and pyruvate kinase L were observed. The resulting enzyme pattern was apparently different from that in dietary induction. Principal component analysis revealed that the degree of enzyme deviation in the injured liver was much greater than that in the regenerating liver after partial hepatectomy and was closer to that in fetal liver or hepatoma tissue.
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PMID:Undifferentiated patterns of key carbohydrate-metabolizing enzymes in injured livers. I. Acute carbon-tetrachloride intoxication of rat. 17 79

The efficacy of silymarin treatment in preventing biochemical and histological alterations in CCL4-induced liver cirrhosis in rats was studied. Four groups of rats were treated with: (1) CCL4; (2) mineral oil; (3) CCL4 + silymarin; and (4) silymarin. All animals were sacrificed 72 h after the end of treatments. The activities of alkaline phosphatase (alk. phosp.), gamma-glutamyl transpeptidase (GGTP), glutamic pyruvic transaminase (GPT) and glucose-6-phosphatase (G6Pase), and bilirubin content were determined in serum. Na+, K+-ATPase and Ca++-ATPase activities were measured in isolated plasma membranes. Lipoperoxidation, triglycerides (TG), and glycogen contents were also measured in liver homogenates. Liver cirrhosis was evidenced by significant increases in liver collagen, lipoperoxidation, serum activities of alk. phosp., GGTP, GPT, G6Pase, bilirubin content, and liver TG. Activities of ATPases determined in plasma membranes were significantly reduced, as was liver glycogen content. Silymarin cotreatment (50 mg/kg b.wt) completely prevented all the changes observed in CCL4-cirrhotic rats, except for liver collagen content which was reduced only 30% as compared to CCL4-cirrhotic rats. Silymarin protection can be attributed to the agent's antioxidant and membrane-stabilizing actions.
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PMID:Prevention of CCL4-induced liver cirrhosis by silymarin. 254 40

In this study, we evaluated the protective activity of aqueous extract of jaggery against CCl4-induced hepatic-renal damage in rats. Jaggery was administered in one group at doses of 250, 500 and 750 mg/ kg body weight (bwt) (p.o., once only), and CCL4 was administered in another group at a dose of 1.5 ml/kg bwt (i.p., once only) to evaluate the protective effect of jaggery on induced oxidative damage in rats. Various blood and tissue biochemical studies were performed. The administration of toxicant significantly altered blood biochemical variables. Hepatic and renal lipid peroxidation (LPO) levels increased significantly, whereas considerable depletion was observed in reduced glutathione (GSH) level after intoxication. A remarkable decrease was observed in the activities of adenosine triphosphatase (ATPase) and glucose-6-phosphatase (G-6-Pase) after induction of toxicity. Treatment with extract at three different altered all measured biochemical variables, but greater hepatic-renal protection was observed at higher doses (750 mg/kg bwt) than at lower does (250 and 500 mg/kg bwt). Jaggery also reversed histopathological alterations. Thus, it may be concluded that jaggery can be used to reduce hepatic and renal damage and may serve as an alternative medicine in hepatic and renal etiology.
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PMID:Jaggery protects hepatorenal injury induced by acute exposure to carbon tetrachloride in Wistar rats. 2375 47