Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of exercise regimens on the enzyme histochemical changes of articular chondrocytes of the humeral heads in adult shepherd-type dogs were studied. One group of 4 dogs was exercised by walking on a flat surface 5 days a week for 6 months. A 2nd group of 4 dogs was exercised under the same conditions, except that the dogs were forced to walk over platforms placed in their path. Three control dogs were exercised ad libitum in their housing area. In all dogs, the reactivity of lactic acid dehydrogenase was quite strong nicotinamide dinucleotide dehydrogenase was moderate, and glucose-6-phosphatase was week. Succinic acid dehydrogenase uridine diphosphate (UDP)-galactose-4-epimerase, and UDP-N-acetylglucosamine-4-epimerase were of weakly moderate staining reactivity. Consistent regional or laminar variability was not found among the chondrocytic populations of the exercised and control groups for the reactivity of the enzymes studied. However, regional and/or laminar variabilities in individuals of the experimental groups were identified. The weak reactivity of glucose-6-phosphatase as seemingly contradictory to the presence of intracellular lipids of adult articular chondrocytes. Lipid synthesis was suggested as a mechanism to store excessive quantities of hydrogen ions in an innocuous form, rather than in the potentially deleterious by-product of anaerobic glycolysis, lactic acid.
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PMID:Effects of exercise on the histochemical changes of articular chondrocytes in adult dogs. 680 69

Toxicity and bioaccumulation of the insecticide "Raid" was determined to assess total animal dietary exposures in a nonoccupational environment. The study focused primarily on dietary exposure concentrations (25-960 microg/g) of the ingredients of Raid administered to rats for 10 days. Tissue concentrations of the insecticide were determined by a high-pressure liquid chromatography method, whereas established methods were used to assess the tissue levels of glucose-6-phosphate and lactic acid dehydrogenase. Results show that animal mortality progressively increased with increasing concentrations while growth (in weight) decreased. Bioaccumulation of the insecticide in the tissues was in the order of lipid > muscle > liver > brain. The indices of toxicity showed no significant effect in brain, but significant reduction of glucose-6-phosphatase and lactic acid dehydrogenase levels were observed in muscle and liver. These results suggest an inhibition of some key metabolic enzymes resulting from accumulation of the insecticide components in the tissues.
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PMID:Toxicity and bioaccumulation of the insecticide "Raid" in Wister rats. 1878 63