Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.9 (glucose-6-phosphatase)
 3,081 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In native cryostat tissue sections of adult female albino rat liver the activities of succinate dehydrogenase (E. C. 1.3.99.1), glucose-6-phosphatase (E. C. 3.1.3.9) and malic enzyme (E. C. 1.1.1.40) were histochemically demonstrated and planimetrically determined. The areas of the enzymes with a maximum activity in the periportal regions, namely SDH and G-6-Pase, were respectively 34% and 41% of the whole parenchyma. Malic enzyme showed a maximum activity in the perivenous region, which consisted of about 53% of the total parenchyma. The zonal distribution of enzyme activities is related only to the terminal vessels; in the vicinity of the preterminal vessels an irregular distribution pattern was found. The results further support the assumption of the bifunctionality of liver parenchyma.
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PMID:[Quantitative investigations of the zonal distribution of SDH, G6Pase and malic enzyme activity in liver parenchyma (author's transl)]. 21 84

Hyperinsulinemia was produced in fetal rhesus monkeys for 21 days in the last third of gestation by subcutaneous pork insulin injected at 19 U a day. Plasma insulin concentrations in treated fetuses (N = 4) were 3525 microU/ml. There was no difference in paired pre- and post-treatment fetal plasma glucose concentration. Activity of the hepatic enzymes that promote glucose utilization (glucokinase and hexokinase) and glycolysis (phosphofructokinase, pyruvate kinase, and pyruvate dehydrogenase) was unaffected. Similarly, glycogen metabolism enzymes (active and inactive synthase and phosphorylase) were unaltered. Two gluconeogenic enzymes (PEPCK and glucose-6-phosphatase) were diminished in the treated group compared with controls. Fetal hyperinsulinemia enhanced lipogenic and NADPH-producing enzyme activities, as evidenced by a twofold increase in fatty acid synthase and in citrate cleavage enzyme activity. Malic enzyme was absent. Hyperinsulinemia with euglycemia (1) increases the activity of enzymes that participate in lipogenesis, (2) decreases some of those controlling gluconeogenesis, and (3) has no effect on the enzymes of glycolysis.
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PMID:Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism. 22 50

The influence of two carbohydrates, starch and glucose, on hepatic enzyme activities of juvenile tilapia,Oreochromis niloticus xO. aureus, were investigated. Fish were fed either starch or glucose diet solely for 12 weeks or fed either starch or glucose diet for the first 6 weeks and then switched the diet each other for the last 6 weeks. Fish fed only the starch diet gained more (p < 0.05) body weight, had better feed conversion, higher protein deposition and energy retention values than fish fed the glucose diet. These parameters generally decreased in fish when the starch diet was fed first and then switched to the glucose diet, or increased in fish when the glucose diet was fed first and then switched to the starch diet. The starch - fed fish had higher body lipid content than glucose - fed fish. Body lipid decreased in fish transferred from the starch to glucose diet orvice versa when fish were transformed from the glucose to the starch diet. Hepatic hexokinase, phosphofructokinase, and glucose-6-phosphatase activities in fish were not affected by the different dietary regimes. Malic enzyme (ME), glucose-6-phosphate dehydrogenase (G-6-PD) and phosphogluconate dehydrogenase (PGD) activities were higher in the fish fed the starch diet than in those fed the glucose diet. Changing the diet from starch to glucose decreased ME, G-6-PD and PGD activities, whereas, changing the diet from the glucose to the starch increased these enzyme activities in fish liver. These results suggest that lipogenic enzyme activity can adapt to dietary carbohydrates in the fish liver.
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PMID:Hepatic enzyme adaptation to different dietary carbohydrates in juvenile tilapiaOreochromis niloticus xO. aureus. 2419 63