Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.8 (phytase)
 1,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2 x 6 pigs continuously housed in metabolic cages from 25-100 kg weight were fed N-reduced diets based on barley, maize and soybean meal. Diet I (control) contained in FM (fresh matter) 0.56%, 0.48% and 0.46% P (feeding phases A: 25-50 kg, B: 50-75 kg, C: 75-100 kg weight) and 0.76%, 0.71% and 0.68% Ca. Diet II was low in P (0.46%, 0.40%, 0.32%) and Ca (0.69%, 0.62%, 0.52%) and 800 U Aspergillus-phytase per kg were added. Analyzed cadmium concentrations in diet I were 23.4, 19.9 and 13.7 micrograms/kg FM and 20.6, 14.9 and 12.7 micrograms/kg FM in diet II respectively. At 100 kg weight in both treatment groups low cadmium concentrations in liver (11.8 vs. 17.3 micrograms Cd/kg FM) and kidneys (59.6 vs. 102 micrograms Cd/kg FM) were found. Contrary to findings for rats fed semisynthetic diets enriched with high CdCl2 levels, phytase supplementation to the P- and Ca-reduced pig diet with a low Cd concentration significantly enhanced liver and kidney cadmium accumulation. Differences in dietary Cd levels, the binding form of Cd in the diets and the duration of the experimental trials may partially explain the differences found between rats and pigs. Complex interactions between cadmium and various elements, especially calcium, might also have additionally influenced the carry over of cadmium in the present study. Irrespective of the dietary treatment, liver and kidney cadmium concentrations in both groups were considerably lower than maximal permitted values.
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PMID:Effect of microbial phytase on cadmium accumulation in pigs. 898 14

This study evaluated the effect of increasing levels of dietary microbial phytase on the bioavailability of zinc and the accumulation of cadmium and lead in growing rats. Five groups of seven albino rats (initial average weight 47 g) were housed individually and fed phytate-rich diets (7 g/kg) based on maize, soya bean meal, corn starch and soya bean oil over a 4-week experimental period. The basal diet contained 24 mg zinc (native concentration), 10 mg lead as Pb(CH3COO)2.3H2O and 5 mg cadmium as CdCl2 per kg and was supplemented with 0, 250, 500, 1000 and 2000 U phytase from Aspergillus niger per kg diet. Supplementation of microbial phytase significantly increased apparent zinc absorption. Differences in zinc bioavailability due to supplementation of the diet with microbial phytase were evident in zinc concentration in plasma, femur and testes as well as in the percentage unsaturated plasma zinc binding capacity and the activity of the zinc metalloenzyme alkaline phosphatase. Cadmium concentrations in liver and kidneys were not significantly altered in response to the different dietary treatments. There was a tendency for femur lead concentration to be increased in response due to the phytase supplementation.
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PMID:Effect of microbial phytase on zinc bioavailability and cadmium and lead accumulation in growing rats. 948 59