Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.5 (5'-nucleotidase)
 3,167 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adenosine deaminase (ADA) and 5'-nucleotidase (5'-N) activity and cytotoxic activity (CTA) of natural killer cells (NK-cells) isolated from human peripheral blood were studied. These cells were affected by culture medium obtained after the contact of tumour cells with NK-cells, the degree of malignancy in these cells being different. It has been established that pretreatment of NK-cells with culture medium from highly malignant cells and containing PGE, causes a sharp inhibition of their CTA, which is accompanied by an essential decrease of the ADA activity and an increase of the 5'-N activity in these cells as compared with the control.
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PMID:[Effect of the prostaglandin E produced by tumor cells on the enzymatic activity of adenosine metabolism and on human natural killer cytotoxic activity]. 254 31