Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.5 (5'-nucleotidase)
 3,167 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A pleiotropic mutation (cpm) which is localised in the vicinity of the spoA gene of Bacillus subtilis chromosome has been described. The mutation inhibits spore formation, renders bacteria auxotrophic for adenine and tyrosine, increases sensitivity to antibiotics, decreases cell motility and the ability to grow on D-ribose and D-xylose, inhibits growth of bacteriophages PBS1 and AR9 as well as enhances activity of alkaline proteinase and alpha-amylase. At the same time, the cpm mutants acquire the ability to produce inosine. Inosine excretion is connected with more than 50- and 5-fold increase in activity of 5'-nucleotidase in respect to IMP and AMP, accordingly, and 10-fold decrease in activity of purine nucleoside phosphorylase. Biosynthesis of inosine and Ade- phenotype of the cpm mutant are not mediated by the change in activity of sAMP synthetase. The nature and mechanism of action of the cpm mutation are under discussion.
 ...
PMID:[A new pleiotropic mutation affecting purine metabolism, sporulation and biosynthesis of exoenzymes in Bacillus subtilis]. 177 39

Highly sensitive techniques have been used for the assay of a range of marker enzymes including lactase, sucrase, alkaline phosphatase, leucyl-beta-naphthylamidase (brush border), and 5'-nucleotidase (basolateral membrane) in jejunal biopsy homogenates from patients with adult coeliac disease with and without steatorrhoea and from a control group. The absorption of D-xylose and vitamin B12 was compared in the two groups with coeliac disease. All enzymes assayed were equally depressed in both groups of coeliac disease as compared with the controls. The absorption of D-xylose and vitamin B12 were reduced in the patients with steatorrhoea compared with those without steatorrhoea. The findings suggest that lack of steatorrhoea in some patients with coeliac disease is due to better preservation of the ileal function rather than to a less severe jejunal mucosal injury.
 ...
PMID:Enzyme activities in jejunal biopsy samples from patients with adult coeliac disease with and without steatorrhoea. 632 31