Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.5 (5'-nucleotidase)
 3,167 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activities of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase were found to be significantly higher in erythrocytes from newborn infants than in erythrocytes from adults, and approximated those observed in patients with deficiency of hypoxanthine-guanine phosphoribosyltransferase. Enzyme activities were increased to a varying extent in patients with reticulocytosis. The results are discussed in relation to red cell age and stabilization of the enzymes by phosphoribosylpyrophosphate. Pyrimidine-5'-nucleotidase was assayed by a new radiochemical method involving thin-layer chromatography for separation of product from substrate. Enzyme activity was higher with orotidine monophosphate than with uridine monophosphate. The activity of this enzyme was similar in erythrocyte of newborns and adults.
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PMID:Pyrimidine metabolism in erythrocytes of the newborn. 43 86