Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.5 (
5'-nucleotidase
)
3,167
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The nucleoside analog acyclovir (9-[2-hydroxy-ethoxy)methyl]guanine or acycloguanosine;
ACV
) inhibited the in vitro transformation of NIH 3T3 cells by Abelson murine leukemia virus and the proliferation of abl- and bcr-abl-transformed hemopoietic murine cell lines. This effect is selective since
ACV
at the same concentration had no effect on the src and Ha-ras transformation of NIH 3T3 cells or on the proliferation of hemopoietic cells transformed by those oncogenes. The inhibitory effect on proliferation of abl-transformed cells correlated with the extent of
ACV
triphosphate formation and incorporation into cellular DNA that was greater than that in normal or other oncogene-transformed cells. The increased
ACV
triphosphate formation might be due to a higher level of
5'-nucleotidase
, the enzyme responsible for trace levels of
ACV
phosphorylation in uninfected cells.
...
PMID:Selective inhibition of proliferation in v-abl- and bcr-abl-transformed cells by a nucleoside analog. 133 Oct 46
