Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.5 (
5'-nucleotidase
)
3,167
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is shown that patients with
acute myocardial infarction
and with chronic coronary insufficiency present an elevated
5'-nucleotidase
and adenosine-desaminase activity. In clinically healthy persons examined after a physical exercise test the activity of
5'-nucleotidase
and adenosine-desaminase declines. In most patients with chronic coronary insufficiency an increased activity of enzymes responsible for the metabolism of adenosine, above all of
5'-nucleotidase
, is registered after a graded physical exertion test.
...
PMID:[Activity of enzymes controlling adenosine metabolism in ischemic heart disease]. 89 93
Magnesium (Mg(2+)) is well known as a natural Ca channel blocker, and has various actions to benefit for the cardiovascular system. The point of action is culminated to (1) Ca antagonism, (2) beta-adrenoceptors blocking action, and (3) anti-platelet action. Because Mg(2+) is one of physiology materials, more ideal effect can be expected than Mg(2+). On the other hand, in the new large-scale clinical trial of
acute myocardial infarction
(MAGIC), Mg(2+) was not able to show the expected outcomes although Mg(2+) is an important co-factor of
5'-nucleotidase
activity which is a production enzyme of adenosine and may show cardioprotective effect through adenosine production increase. Therefore, we must say that we need further investigation on the role of Mg(2+) on the cardiovascular protection.
...
PMID:[A role of magnesium: magnesium in the therapy for cardiovascular diseases]. 1569 68
