Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.5 (5'-nucleotidase)
 3,167 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Biopsy specimens from the antral and body part of the stomach were studied for a range of marker enzymes in 11 patients with superficial gastritis, 9 patients with atrophic gastritis, and 31 Billroth-II-resected patients and compared with activities found in controls with normal gastric mucosa. In the antral part of the stomach increased gamma-glutamyltransferase activity was found in superficial (p less than 0.01) and atrophic gastritis (p less than 0.05), whereas monoamine oxidase activity was decreased in superficial (p less than 0.01) and atrophic gastritis (p less than 0.05). In the body part, increased activity of gamma-glutamyltransferase (p less than 0.01) and acid-beta-glucuronidase (p less than 0.01) was found in superficial gastritis. In atrophic gastritis increased activities for lactase (p less than 0.01), alkaline phosphatase (p less than 0.05), leucyl-beta-naphthylamidase (p less than 0.05), gamma-glutamyltransferase (p less than 0.05), 5'-nucleotidase (p less than 0.01), N-acetyl-beta-D-glucosaminidase (p less than 0.05), and acid-beta-glucuronidase (p less than 0.01) were found. Specimens from the gastric remnant showed an enzyme activity pattern similar to that seen in the body in atrophic gastritis, apart from a significantly decreased monoamine oxidase activity (p less than 0.004). Specimens with dysplasia in the gastric remnant showed decreased monoamine oxidase activity when compared with specimens without dysplasia (p less than 0.01).
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PMID:Enzyme activities in human gastric mucosa in gastritis and resected stomachs. 381

Ethanol administration rapidly damages surface epithelial cells of rat stomach, leading to altered cellular plasma membranes. Histamine H2-receptor antagonists (H2RA) have been shown to have preventive properties against ethanol-induced gastric mucosal injury. Therefore, the possible reverting properties of H2RA (cimetidine, ranitidine, and famotidine) were tested in ethanol-induced gastritis. Subchronic ethanol administration elicited a histological profile of gastritis and alterations at the plasma membrane level (diminution of some phospholipids, increased cholesterol, and decreased activity of 5'-nucleotidase). H2RA administration to rats with gastritis promptly corrected the ethanol-induced mucosal damage. In addition, cytosolic enzyme activities (alcohol and lactate dehydrogenases) were also modified by gastritis and treatment with H2RA. In conclusion, our data suggest that H2RA improved restitution of the gastric mucosa contributing to the healing process of the gastric damage. The latter indicates reverting properties of H2RA on gastric damage, as well as their cytoprotective effect already described.
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PMID:Reversion by histamine H2-receptor antagonists of plasma membrane alterations in ethanol-induced gastritis. 894 67