Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.5 (5'-nucleotidase)
 3,167 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen patients with cholestatic disorders were treated for 1 to 5 months with phenobarbital. Primary biliary cirrhosis was diagnosed in seven, sclerosing cholangitis in two, intrahepatic biliary hypoplasia in three, and cholestatic hepatitis in three. Except for the patients with cholestatic hepatitis, in whom marked cholestasis was virtually the only abnormality in liver biopsy specimens, serum bilirubin and bile acid concentrations were diminished during therapy, the hepatic clearance of sulfobromophthalein and 131-I-rose bengal was variably enhanced, and there was relief from pruritus. Serum cholesterol concentrations and other measures of hepatic function were not significantly changed during therapy except for serum alkaline phosphatase activity, which rose in twelve patients. Parallel changes occurred in 5'-nucleotidase, suggesting a hepatic origin for the alkaline phosphatase activity. These studies indicate that phenobarbital therapy is associated with improvement in organic anion clearance in some patients with cholestatic disorders and may be beneficial to such patients.
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PMID:Phenobarbital effects in cholestatic liver diseases. 111 64

Male Wistar rats were treated for 3 weeks with alpha-naphthyl isothiocyanate (ANIT, 5.4 mmol per kg food). Chronic necrotic cholangitis without pronounced transaminasemia and hyperbilirubinemia developed. The activity of 5'-nucleotidase in liver plasma membrane preparations was strongly depressed (3.5 times) while the activities of K+-, Na+- and Mg++-ATPases were not affected. The liver microsomal cytochrome P-450 and cytochrome b5 contents decreased. Elevation of reduced glutathione liver content after challenge with ANIT was recorded. The observed biochemical changes may be important for the pathogenesis of ANIT-induced chronic cholangitis.
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PMID:Biochemical changes in alpha-naphthyl isothiocyanate-induced chronic cholangitis in the rat. 322 62