Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.16 (calcineurin)
17,112 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
calcineurin 8233
protein phosphatase 6862
phosphatase 3963
calmodulin 1785
Mol 1633
threonine 1611
Sep 1125
FK506 992
inhibitor 2 724
calcineurin inhibitor 693
PP2A 687
ATP 652
insulin 563
protein phosphatase-1 554
PP1 548
mTOR 433
cytokine 424
phosphoprotein 354
ATPase 311
MAPK 309
cAMP-dependent protein kinase 309
AMP 306
p38 287
endoplasmic reticulum 286
PKC 266
ERK 247
histone 210
p53 208
ERK1 206
glycogen synthase 203
PKA 203
protein phosphatase 2B 185
IL-2 183
myosin 181
caspase-3 181
CA1 178
CaMKII 177
nuclear factor of activated T-cells 176
FKBP12 175
MAP kinase 174
more...
Disease
cancer 1050
tumor 836
Alzheimer's disease 480
diabetes 369
hypertension 309
atopic dermatitis 267
heart failure 261
depression 225
renal disease 197
ischemia 195
tumorigenesis 155
hepatocellular carcinoma 155
leukemia 144
SDS 141
proteinuria 140
breast cancer 140
neuroblastoma 110
pruritus 109
HIV 106
graft-versus-host disease 106
skin disease 105
tumor growth 100
obesity 94
hepatitis C 94
carcinoma 93
Parkinson's disease 90
Cryptococcus neoformans 90
melanoma 87
psoriasis 87
Down syndrome 83
cardiovascular disease 82
lymphoma 82
hyperlipidemia 81
cytomegalovirus 80
systemic lupus erythematosus 78
type 2 diabetes 77
cold 75
retinoblastoma 75
pertussis 75
tumor progression 69
more...
Symptom
starvation 106
pain 90
seizures 85
diarrhea 37
erythema 32
fatigue 27
collapse 27
headache 23
rundown 20
functional recovery 17
tremor 17
weakness 16
vomiting 14
nausea 14
ataxia 13
exhaustion 12
anesthesia 10
memory loss 9
dyspnea 9
arthralgia 8
overweight 7
abdominal pain 7
discomfort 6
hypothermia 6
myoclonus 6
acidity 6
dry skin 6
stigma 6
discomfort 6
bone pain 5
cough 5
agitation 5
constipation 5
dry eye 5
respiratory distress 5
polyuria 5
acute stress 4
insomnia 4
analgesia 4
oliguria 4
more...
Drug
Dermatol 242
IL-2 183
Tacrolimus 178
lysine 81
MAP 73
IFN-gamma 57
caffeine 53
Cardiovasc 48
ROS 41
Pimecrolimus 33
Gel 33
Belatacept 31
CaCl2 30
CaCl2 30
CaCl2 30
Monit 29
Everolimus 29
Angiotensin II 27
CSF 27
Neoral 25
Forskolin 23
Dial 21
Rituximab 20
ABC 20
K-252a 17
Prograf 17
NADH 16
Campath 16
Campath 16
Leaf 16
CTX 15
Ethanol 15
Asn 15
Parkin 14
Parkin 14
vitamin E 13
Nephron 13
Asthma 12
TAT 12
ascorbate 12
more...
Enzyme
calcineurin 17112
protein kinase 2414
protein phosphatase 2A 1571
mitogen-activated protein kinase 1083
protein kinase C 999
AMPK 358
phosphorylase 356
ERK 333
ATPase 323
CaMKII 284
MEK 229
luciferase 185
GSK 169
phosphodiesterase 155
AMP-activated protein kinase 155
phospholipase C 150
focal adhesion kinase 148
proteasome 142
caspase-3 142
alkaline phosphatase 135
phosphatidylinositol 3-kinase 132
glutathione S-transferase 131
phosphorylase kinase 120
cdc2 115
trypsin 92
myosin light chain kinase 91
adenylate cyclase 78
acid phosphatase 75
thrombin 66
RNA polymerase 65
type 1 protein phosphatase 62
MAP 62
catalase 61
PKG 59
renin 56
superoxide dismutase 55
phosphoinositide 3-kinase 52
NO synthase 51
lactate dehydrogenase 48
AMPK 46
more...
Compound
calcium 3050
threonine 2110
serine 1947
Dec 1216
FK506 1137
DNA 1064
phosphate 741
cAMP 734
tyrosine 703
ATP 652
glucose 539
Clin 481
sodium 480
oxygen 362
AMP 317
acetate 307
Cyclosporine 301
Okadaic acid 301
water 291
glutamate 270
manganese 244
Mg2+ 222
Rapamycin 215
alanine 200
arginine 187
salt 179
creatinine 175
leucine 173
NMDA 172
nitric oxide 171
potassium 171
sulfate 154
SDS 151
MEK 131
cGMP 131
zinc 127
phosphoserine 125
Cardiol 125
lysine 125
cysteine 124
more...