Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
calcineurin
8233
protein phosphatase
6862
phosphatase
3963
calmodulin
1785
Mol
1633
threonine
1611
Sep
1125
FK506
992
inhibitor 2
724
calcineurin inhibitor
693
PP2A
687
ATP
652
insulin
563
protein phosphatase-1
554
PP1
548
mTOR
433
cytokine
424
phosphoprotein
354
ATPase
311
MAPK
309
cAMP-dependent protein kinase
309
AMP
306
p38
287
endoplasmic reticulum
286
PKC
266
ERK
247
histone
210
p53
208
ERK1
206
glycogen synthase
203
PKA
203
protein phosphatase 2B
185
IL-2
183
myosin
181
caspase-3
181
CA1
178
CaMKII
177
nuclear factor of activated T-cells
176
FKBP12
175
MAP kinase
174
more...
Disease
cancer
1050
tumor
836
Alzheimer's disease
480
diabetes
369
hypertension
309
atopic dermatitis
267
heart failure
261
depression
225
renal disease
197
ischemia
195
tumorigenesis
155
hepatocellular carcinoma
155
leukemia
144
SDS
141
proteinuria
140
breast cancer
140
neuroblastoma
110
pruritus
109
HIV
106
graft-versus-host disease
106
skin disease
105
tumor growth
100
obesity
94
hepatitis C
94
carcinoma
93
Parkinson's disease
90
Cryptococcus neoformans
90
melanoma
87
psoriasis
87
Down syndrome
83
cardiovascular disease
82
lymphoma
82
hyperlipidemia
81
cytomegalovirus
80
systemic lupus erythematosus
78
type 2 diabetes
77
cold
75
retinoblastoma
75
pertussis
75
tumor progression
69
more...
Symptom
starvation
106
pain
90
seizures
85
diarrhea
37
erythema
32
fatigue
27
collapse
27
headache
23
rundown
20
functional recovery
17
tremor
17
weakness
16
vomiting
14
nausea
14
ataxia
13
exhaustion
12
anesthesia
10
memory loss
9
dyspnea
9
arthralgia
8
overweight
7
abdominal pain
7
discomfort
6
hypothermia
6
myoclonus
6
acidity
6
dry skin
6
stigma
6
discomfort
6
bone pain
5
cough
5
agitation
5
constipation
5
dry eye
5
respiratory distress
5
polyuria
5
acute stress
4
insomnia
4
analgesia
4
oliguria
4
more...
Drug
Dermatol
242
IL-2
183
Tacrolimus
178
lysine
81
MAP
73
IFN-gamma
57
caffeine
53
Cardiovasc
48
ROS
41
Pimecrolimus
33
Gel
33
Belatacept
31
CaCl2
30
CaCl2
30
CaCl2
30
Monit
29
Everolimus
29
Angiotensin II
27
CSF
27
Neoral
25
Forskolin
23
Dial
21
Rituximab
20
ABC
20
K-252a
17
Prograf
17
NADH
16
Campath
16
Campath
16
Leaf
16
CTX
15
Ethanol
15
Asn
15
Parkin
14
Parkin
14
vitamin E
13
Nephron
13
Asthma
12
TAT
12
ascorbate
12
more...
Enzyme
calcineurin
17112
protein kinase
2414
protein phosphatase 2A
1571
mitogen-activated protein kinase
1083
protein kinase C
999
AMPK
358
phosphorylase
356
ERK
333
ATPase
323
CaMKII
284
MEK
229
luciferase
185
GSK
169
phosphodiesterase
155
AMP-activated protein kinase
155
phospholipase C
150
focal adhesion kinase
148
proteasome
142
caspase-3
142
alkaline phosphatase
135
phosphatidylinositol 3-kinase
132
glutathione S-transferase
131
phosphorylase kinase
120
cdc2
115
trypsin
92
myosin light chain kinase
91
adenylate cyclase
78
acid phosphatase
75
thrombin
66
RNA polymerase
65
type 1 protein phosphatase
62
MAP
62
catalase
61
PKG
59
renin
56
superoxide dismutase
55
phosphoinositide 3-kinase
52
NO synthase
51
lactate dehydrogenase
48
AMPK
46
more...
Compound
calcium
3050
threonine
2110
serine
1947
Dec
1216
FK506
1137
DNA
1064
phosphate
741
cAMP
734
tyrosine
703
ATP
652
glucose
539
Clin
481
sodium
480
oxygen
362
AMP
317
acetate
307
Cyclosporine
301
Okadaic acid
301
water
291
glutamate
270
manganese
244
Mg2+
222
Rapamycin
215
alanine
200
arginine
187
salt
179
creatinine
175
leucine
173
NMDA
172
nitric oxide
171
potassium
171
sulfate
154
SDS
151
MEK
131
cGMP
131
zinc
127
phosphoserine
125
Cardiol
125
lysine
125
cysteine
124
more...