Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.16 (calcineurin)
 17,112 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
calcineurin 8233
protein phosphatase 6862
phosphatase 3963
calmodulin 1785
Mol 1633
threonine 1611
Sep 1125
FK506 992
inhibitor 2 724
calcineurin inhibitor 693
PP2A 687
ATP 652
insulin 563
protein phosphatase-1 554
PP1 548
mTOR 433
cytokine 424
phosphoprotein 354
ATPase 311
cAMP-dependent protein kinase 309
MAPK 309
AMP 306
p38 287
endoplasmic reticulum 286
PKC 266
ERK 247
histone 210
p53 208
ERK1 206
glycogen synthase 203
PKA 203
protein phosphatase 2B 185
IL-2 183
myosin 181
caspase-3 181
CA1 178
CaMKII 177
nuclear factor of activated T-cells 176
FKBP12 175
MAP kinase 174
AKT 164
polypeptide 162
cyclin 159
alpha isoform 159
JNK 159
NMDA receptor 156
tyrosine kinase 155
MEK 155
phosphodiesterase 155
tumor necrosis factor 153
CD4 151
mitogen-activated protein 150
CNB 150
inhibitor-1 150
ubiquitin 146
PI3K 146
Bcl-2 145
PTEN 145
cyclophilin 141
SDS 141
proteasome 140
GSK 139
immunophilin 138
interleukin-2 133
phosphatidylinositol 3-kinase 132
alkaline phosphatase 130
extracellular signal-regulated kinase 129
PP2C 128
angiotensin II 128
DARPP-32 128
casein 125
TNF 123
AP-1 119
RCAN1 117
phosphorylating 113
phosphorylase kinase 111
interferon 109
AMP-activated protein kinase 108
TCR 108
CREB 108
phospholamban 106
NFATc3 105
calpain 105
protein kinase inhibitor 105
collagen 102
IL-4 98
myosin light chain 97
tau protein 96
T cell receptor 94
protein tyrosine phosphatase 94
protein kinase B 94
cyclophilin A 94
c-Jun 93
axonal 91
myosin heavy chain 90
interacting protein 89
IL-6 88
14-3-3 86
amyloid precursor protein 85
lipopolysaccharide 84
nitric oxide synthase 83
membrane-bound 82
GABA 80
NFATc 80
CD28 80
NMR 80
GTP 78
glycogen phosphorylase 78
adenylyl cyclase 77
fused 77
microsomal 77
calcium channel 76
cytochrome c 76
tyrosine phosphatase 76
cyclin-dependent kinase 75
Ang II 75
GST 74
myelin basic protein 74
epidermal growth factor 73
myosin light chain kinase 73
SET 72
ryanodine receptor 72
cardiac muscle 71
ADP 71
IFN 70
NFAT1 70
Rho 70
casein kinase 70
adenylate cyclase 70
thrombin 68
CD8 68
acid phosphatase 68
membrane protein 67
histone H1 67
catenin 65
GTPase 65
c-fos 65
TNF-alpha 65
glutamate receptor 64
ERK2 63
glutathione S-transferase 62
MEK1 62
NFATc4 62
MAP 62
FK506-binding protein 61
p21 61
insulin receptor 60
p65 60
PKG 59
Glycogen synthase 59
thymus 59
IFN-gamma 58
ubiquitin ligase 58
spermatozoa 57
vascular endothelial growth factor 57
lymphoid 57
CD25 56
glucagon 56
renin 56
serine/threonine kinase 55
more...
Disease
cancer 1050
tumor 836
Alzheimer's disease 480
diabetes 369
hypertension 309
atopic dermatitis 267
heart failure 261
depression 225
renal disease 197
ischemia 195
tumorigenesis 155
hepatocellular carcinoma 155
leukemia 144
SDS 141
proteinuria 140
breast cancer 140
neuroblastoma 110
pruritus 109
graft-versus-host disease 106
HIV 106
skin disease 105
tumor growth 100
hepatitis C 94
obesity 94
carcinoma 93
Parkinson's disease 90
Cryptococcus neoformans 90
melanoma 87
psoriasis 87
Down syndrome 83
lymphoma 82
cardiovascular disease 82
hyperlipidemia 81
cytomegalovirus 80
systemic lupus erythematosus 78
type 2 diabetes 77
retinoblastoma 75
cold 75
pertussis 75
renal failure 69
tumor progression 69
nephrotic syndrome 68
prostate cancer 66
carcinogenesis 66
ATM 64
hyperglycemia 64
liver disease 63
virus infection 62
dementia 62
atherosclerosis 61
schizophrenia 61
glomerulosclerosis 58
lupus 57
immunodeficiency 57
ventricular hypertrophy 56
heart disease 56
stroke 55
asthma 54
glioma 53
MCF 52
epilepsy 52
dermatitis 52
cirrhosis 52
Blocking 51
autoimmune disease 50
rheumatoid arthritis 50
osteoporosis 50
skin cancer 49
encephalopathy 48
eczema 47
chronic renal failure 46
glioblastoma 46
cardiomyopathy 46
herpes simplex 45
squamous cell carcinoma 44
fungal infection 44
anemia 44
infectious diseases 44
acute myeloid leukemia 44
adenocarcinoma 43
myocardial infarction 42
vitiligo 42
metastases 41
aspergillosis 41
hepatitis 40
PPP 38
dyslipidemia 38
lung cancer 38
cerebral ischemia 38
sepsis 38
sepsis 37
cognitive impairment 37
colorectal cancer 36
amyotrophic lateral sclerosis 36
Infection 36
ulcerative colitis 35
Huntington's disease 35
inflammatory bowel disease 34
thrombocytopenia 34
lupus 34
glucose intolerance 34
APC 34
Epstein 33
memory impairment 32
colon cancer 32
metabolic syndrome 32
lupus nephritis 31
pneumonia 31
dilated cardiomyopathy 31
glomerulonephritis 31
arthritis 31
plaque 30
Contact Dermatitis 30
LTD 29
diabetic nephropathy 28
multiple sclerosis 28
chronic myeloid leukemia 28
GSH 28
tuberculosis 28
candidiasis 27
pancreatic cancer 26
hepatitis B 26
LBD 26
B-cell lymphoma 25
malaria 25
Mycobacterium 25
colitis 25
renal insufficiency 25
lichen sclerosus 25
pheochromocytoma 25
myocardial ischemia 25
Kaposi's sarcoma 24
renal impairment 24
acute renal failure 23
TTP 23
hypercholesterolemia 23
type 1 diabetes 22
acute lymphoblastic leukemia 22
muscular atrophy 22
mole 22
seborrheic dermatitis 21
membranous nephropathy 21
lichen planus 21
vaccinia 20
non-small cell lung cancer 20
myopathy 20
mole 20
AIDS 20
Leukemia 19
Duchenne muscular dystrophy 19
lung carcinoma 19
Crohn's disease 19
hematologic malignancies 19
PTP 19
vascular disease 19
ovarian cancer 18
NAME 18
liver cancer 18
CAN 18
bone disease 18
more...
Symptom
starvation 106
pain 90
seizures 85
diarrhea 37
erythema 32
fatigue 27
collapse 27
headache 23
rundown 20
tremor 17
functional recovery 17
weakness 16
vomiting 14
nausea 14
ataxia 13
exhaustion 12
anesthesia 10
dyspnea 9
memory loss 9
arthralgia 8
abdominal pain 7
overweight 7
discomfort 6
acidity 6
myoclonus 6
stigma 6
discomfort 6
dry skin 6
hypothermia 6
cough 5
constipation 5
dry eye 5
polyuria 5
respiratory distress 5
bone pain 5
agitation 5
acute stress 4
analgesia 4
insomnia 4
lethargy 4
oliguria 4
tense 3
angina 3
paresthesia 3
hyperoxia 3
thinning 3
acute pain 3
cachexia 3
myalgia 3
hypotonia 3
skin irritation 3
splenomegaly 3
dysesthesia 2
chorea 2
anorexia 2
shortness of breath 2
dysarthria 2
Anoxia 2
dystonia 2
dysuria 2
blurred vision 2
disturbed balance 2
flushing 2
back pain 2
hepatomegaly 2
twitching 2
neuralgia 2
ENT 2
catatonia 2
cerebellar ataxia 2
leg pain 2
CSR 2
photophobia 1
Vulvodynia 1
stridor 1
Gastrointestinal symptoms 1
neurological disability 1
No adverse effect 1
intention tremor 1
tenesmus 1
Decreased activity 1
trigeminy 1
anosmia 1
sleepiness 1
nausea and vomiting 1
KIDNEY 1
loss of balance 1
Stiffness 1
tinnitus 1
otalgia 1
scaly skin 1
Ill 1
regurgitation 1
bladder pain 1
bradykinesia 1
Fluctuation 1
sore throat 1
abnormal gait 1
skin pain 1
Spots 1
phosphatemia 1
flank pain 1
knee pain 1
tingling 1
heartburn 1
Neuropathic pain 1
acute abdominal pain 1
orofacial pain 1
livedo 1
hepatosplenomegaly 1
hunger 1
consciousness disturbance 1
leg edema 1
microbial colonization 1
Sedation 1
forgetfulness 1
polydipsia 1
Burning 1
Catch 1
renal colic 1
rigors 1
chest pain 1
muscle cramps 1
Drug
Dermatol 242
IL-2 183
Tacrolimus 178
lysine 81
MAP 73
IFN-gamma 57
caffeine 53
Cardiovasc 48
ROS 41
Gel 33
Pimecrolimus 33
Belatacept 31
CaCl2 30
CaCl2 30
CaCl2 30
Everolimus 29
Monit 29
CSF 27
Angiotensin II 27
Neoral 25
Forskolin 23
Dial 21
ABC 20
Rituximab 20
K-252a 17
Prograf 17
NADH 16
Campath 16
Campath 16
Leaf 16
Ethanol 15
CTX 15
Asn 15
Parkin 14
Parkin 14
Nephron 13
vitamin E 13
Asthma 12
Trifluoperazine 12
ascorbate 12
TAT 12
ICI 11
TAC 10
DNase I 10
Basiliximab 9
Basiliximab 9
EE2 9
Rapamune 8
ZnCl2 8
ZnCl2 8
Glutathione 8
PCP 7
Daclizumab 7
Allergen 7
CAM 7
Alanine 6
Histamine 6
Arsenic trioxide 6
CoCl2 5
Caspofungin 5
Capsicum 5
CoCl2 5
Mycophenolic acid 5
PTH 5
Fluconazole 5
Glucagon 5
RFP 5
Taxol 5
BH4 5
CDP 4
Ginseng 4
Doxycycline 4
Ouabain 4
Fructose 4
Prednisolone 4
nitroglycerin 4
Prednisone 4
ROC 4
Adriamycin 4
MRC 4
SMP 4
Indomethacin 4
Budesonide 4
Methylprednisolone 3
Bortezomib 3
CTX 3
TTC 3
Efalizumab 3
L-tyrosine 3
Retinoic acid 3
Efalizumab 3
Lovastatin 3
Nephron 3
CTX 3
ISP 3
uPA 3
ETA 3
Rolipram 3
FAD 3
Spectrum 3
Retinoic Acid 3
Nitric Oxide 3
Sorafenib 3
NVP 3
TiO2 3
Etoposide 3
CIA 2
Kenyan 2
Fulvestrant 2
IPD 2
ZnO 2
pyridoxal phosphate 2
MDS 2
ACT 2
TES 2
Coal tar 2
Rosiglitazone 2
EPA 2
Infliximab 2
G-CSF 2
Portal 2
Theophylline 2
Albumin 2
Growth hormone 2
CED 2
ENT 2
NH3 2
Propofol 2
Maltose 2
Fludarabine 2
DMAP 2
Fraction 2
GHRP 2
DHT 2
Estrogens 2
Vitamin B12 2
Diamminedichloroplatinum 2
Alefacept 2
p75 2
Growth hormone 2
NBT 2
Antithymocyte globulin 2
PTC 2
IL-11 2
Infliximab 2
Cellcept 2
Cellcept 2
Oseltamivir 2
ampicillin 2
CTA 2
Lenalidomide 2
Fingolimod hydrochloride 2
GRF 2
Dihydro 2
CCL 2
DHT 2
TEL 2
Artesunate 2
Mutagen 2
AC2 2
more...
Enzyme
calcineurin 17112
protein kinase 2414
protein phosphatase 2A 1571
mitogen-activated protein kinase 1083
protein kinase C 999
AMPK 358
phosphorylase 356
ERK 333
ATPase 323
CaMKII 284
MEK 229
luciferase 185
GSK 169
AMP-activated protein kinase 155
phosphodiesterase 155
phospholipase C 150
focal adhesion kinase 148
caspase-3 142
proteasome 142
alkaline phosphatase 135
phosphatidylinositol 3-kinase 132
glutathione S-transferase 131
phosphorylase kinase 120
cdc2 115
trypsin 92
myosin light chain kinase 91
adenylate cyclase 78
acid phosphatase 75
thrombin 66
RNA polymerase 65
type 1 protein phosphatase 62
MAP 62
catalase 61
PKG 59
renin 56
superoxide dismutase 55
phosphoinositide 3-kinase 52
NO synthase 51
lactate dehydrogenase 48
tyrosine hydroxylase 46
AMPK 46
APC 44
TOR 44
P-glycoprotein 44
IKK 42
NADPH oxidase 41
PTPase 40
acetyl-CoA carboxylase 40
PDE 40
NADPH oxidase 39
guanylate cyclase 37
polo-like kinase 1 36
reverse transcriptase 36
caspase-8 35
peptidyl-prolyl cis-trans isomerase 34
PARP 31
phospholipase A2 31
pyruvate dehydrogenase 30
pyruvate kinase 28
ACS 28
MEKK1 27
caspase-9 27
peroxidase 26
PDK1 26
NOS 26
hexokinase 25
CYP3A4 25
pyruvate dehydrogenase 22
pyruvate dehydrogenase 22
cellulose synthase 22
phosphoenolpyruvate carboxykinase 22
phosphoenolpyruvate carboxykinase 21
glycogen synthase phosphatase 21
phosphoenolpyruvate carboxykinase 21
p-nitrophenylphosphatase 20
chitin synthase 20
chymotrypsin 20
cathepsin K 20
complex I 19
beta-galactosidase 19
RNase 19
RNase 18
glucokinase 18
calcium pump 17
IMP dehydrogenase 17
AMP-activated kinase 17
kinesin 16
collagenase 16
acetylcholinesterase 15
3-hydroxy-3-methylglutaryl-CoA reductase 15
phospholipase D 15
cathepsin D 14
CPT 14
creatine kinase 14
neutral sphingomyelinase 14
topoisomerase 14
separase 13
CPT 13
CPT 13
ACE 13
DNA polymerase 13
aequorin 13
phosphoenolpyruvate carboxylase 12
phosphatidate phosphatase 12
nitrate reductase 12
succinate dehydrogenase 12
chloramphenicol acetyltransferase 12
TAT 12
ATP synthase 12
topoisomerase 12
caspase-1 11
phosphofructokinase 11
urokinase-type plasminogen activator 11
Mg2+-ATPase 11
DNase 11
nitrate reductase 10
glutathione peroxidase 10
3-hydroxy-3-methylglutaryl coenzyme A reductase 10
nitrate reductase 10
nitrate reductase 10
nitrate reductase 10
GRK5 10
glucose-6-phosphatase 10
citrate synthase 10
nitrate reductase 10
glyceraldehyde-3-phosphate dehydrogenase 10
cytochrome oxidase 9
phosphoglucomutase 9
hormone-sensitive lipase 9
SPS 9
glutamine synthetase 9
lysozyme 9
cGMP phosphodiesterase 9
ribonuclease 9
cathepsin L 9
alanine aminotransferase 9
DNA methyltransferase 8
MPP 8
choline acetyltransferase 8
ornithine decarboxylase 8
peroxiredoxin 8
m-calpain 8
malate dehydrogenase 8
hexosaminidase 8
thiopurine methyltransferase 8
ribonuclease 8
branched-chain alpha-keto acid dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 8
histone acetyltransferase 7
aspartate aminotransferase 7
PGM 7
enolase 7
pyruvate dehydrogenase phosphatase 7
glyceraldehyde-3-phosphate dehydrogenase 7
adenosine deaminase 7
adenosine deaminase 7
tyrosinase 7
caspase-2 7
alpha-amylase 7
caspase-2 7
more...
Compound
calcium 3050
threonine 2110
serine 1947
Dec 1216
FK506 1137
DNA 1064
phosphate 741
cAMP 734
tyrosine 703
ATP 652
glucose 539
Clin 481
sodium 480
oxygen 362
AMP 317
acetate 307
Cyclosporine 301
Okadaic acid 301
water 291
glutamate 270
manganese 244
Mg2+ 222
Rapamycin 215
alanine 200
arginine 187
salt 179
creatinine 175
leucine 173
NMDA 172
nitric oxide 171
potassium 171
sulfate 154
SDS 151
cGMP 131
MEK 131
zinc 127
lysine 125
phosphoserine 125
Cardiol 125
cysteine 124
TNF 123
DEAE 116
hydrogen 116
Insulin 115
ethanol 104
AMPA 104
PMA 103
PMA 100
His 97
nitrogen 90
Asp 85
Calyculin A 83
Phe 83
glycerol 80
GABA 80
GABA 80
GTP 78
methionine 78
proline 78
ADP 74
ADP 72
SET 72
ADP 71
MAP 68
COS 68
Serine 65
EDTA 64
EDTA 64
galactose 63
vitamin D 61
Glycogen synthase 58
Ang II 56
nickel 56
Triton X-100 55
urea 53
ABA 53
caffeine 53
H2O2 52
ammonium 51
iron 49
PEG 48
Microcystin-LR 48
cobalt 46
Dopamine 45
aldosterone 45
retinoic acid 44
NH2 43
tryptophan 42
5-HT 38
pyrimidine 37
CoA 36
Glycogen 36
Neuronal 35
PEG 35
CAN 35
Gly 34
bromide 34
copper 34
GSH 34
GSH 34
Cer 33
gamma-aminobutyric acid 32
Mycophenolate mofetil 32
NADPH 32
glutamine 32
NADPH 32
Angiotensin II 32
CaCl2 30
Ile 30
salicylic acid 30
BNP 29
ABA 29
LTD 29
noradrenaline 28
ACS 28
tryptophan 28
ACS 28
MDA 27
MTT 27
TPA 26
tryptophan 26
tryptophan 26
TPA 26
L-threonine 25
adenylate 25
CO2 25
aspartic acid 25
homocysteine 24
TOF 24
GMP 24
nitrate 24
glutamic acid 23
NAD 23
Forskolin 23
uridine 23
Optimal 22
aspartic acid 22
iodine 22
VM-26 21
acrylamide 21
CNA 21
Dial 21
adenosylmethionine 20
Glutamate 20
Casein 20
TMA 19
aspartic acid 19
aspartic acid 19
Triton 19
TMA 19
Phorbol 19
NAD 19
pyrimidine 19
cyanide 18
Tyrosine 18
PPi 18
Phosphatidylinositol 18
MgCl2 18
cadmium 18
FK520 18
more...