Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca
2+
entry (SOCE) and
calcineurin
signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca
2+
influx through Ca
2+
release-activated Ca
2+
channels. Based on an in silico target prediction we identified multiple miR-34a-5p target genes within both pathways that are implicated in the balance between T-cell activation and apoptosis including ITPR2, CAMLG, STIM1,
ORAI3
, RCAN1, PPP3R1, and NFATC4. Functional analysis revealed a decrease in Ca
2+
activated
calcineurin
pathway activity measured by a reduced IL-2 secretion due to miR-34a-5p overexpression. Impacting SOCE and/or downstream
calcineurin
/NFAT signaling by miR-34a-5p offers a possible future approach to manipulate immune cells for clinical interventions.
...
PMID:Modulation of intracellular calcium signaling by microRNA-34a-5p. 3026 62
