Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Proteins encoded by immediate-early response (IER) family genes, IER2, IER5, and
IER5L
, share homology at their N-terminal regions. IER5 binds to protein phosphatase 2A (
PP2A
) and enhances dephosphorylation of
PP2A
target proteins such as heat shock factor HSF1. Here, we show the expression of IER family genes and the target protein-specific function of IER proteins. The IER homology regions of IER2 and
IER5L
are required for the interaction with
PP2A
. Expression of IER2 and
IER5L
in cells leads to reduced phosphorylation of HSF1 and derepression of its transcriptional activity. Although IER5 and
IER5L
enhance dephosphorylation of ribosomal protein S6 kinase, IER2 fails to do so. IER2, IER5, and
IER5L
all bind to the cell cycle regulator CDC25A and convert it to the hypophosphorylated form, which causes dissociation from 14-3-3 regulatory protein. IER5 differentially regulates CDC25A levels in cells under normal and thermal stress conditions. These results suggest that IER proteins are target protein-specific regulators of
PP2A
activity and modulate cell proliferation through CDC25A activity.
...
PMID:IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A. 3059 13
