Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The scavenger receptor expressed by endothelial cells (SREC)-I was originally identified in a human endothelial cell line by expression cloning. Subsequently it was shown that the cytoplasmic domain of
SREC-I
mediates the neurite-like outgrowth of murine fibroblastic L cells through interaction with advillin, a member of gelsolin/villin family of actin regulatory proteins. In this work, we further searched for a binding protein to the cytoplasmic domain of the receptor, which might be required for the morphological change of L cells and identified
protein phosphatase
1alpha (PP1alpha) as a binding protein to this domain. It was revealed that PP1alpha binds to the central region (i.e., residues between 461 and 560) of the cytoplasmic domain of the receptor. By the expression of truncated forms of
SREC-I
lacking C-terminal amino acids, it was suggested that the morphological change is a two step process (i.e., elongation/sprouting and process formation) mediated by two distinctive cytoplasmic regions of
SREC-I
and PP1alpha is required for the process formation. Our system may be useful for the elucidation of the mechanism of morphological maturation of neuronal cells such as dorsal root ganglion neurons that express
SREC-I
during early development.
...
PMID:Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth. 1758 71
