Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Skeletal muscle uses calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium levels activate
calcineurin
, a serine/threonine phosphatase, resulting in the expression of a set of genes involved in the maintenance, growth, and remodeling of skeletal muscle. In this review, we discuss the effects of
calcineurin
activity on hypertrophy, regeneration, and disorders of skeletal muscle. Calcineurin is a potent regulator of muscle remodeling, enhancing the differentiation through upregulation of myogenin or MEF2A and downregulation of the Id1 family and myostatin. Foxo may also be a downstream candidate for a
calcineurin
signaling molecule during muscle regeneration. The strategy of controlling the amount of
calcineurin
may be effective for the treatment of muscular disorders such as DMD,
UCMD
, and LGMD. Activation of
calcineurin
produces muscular hypertrophy of the slow-twitch soleus muscle but not fast-twitch muscles.
...
PMID:The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. 2037 69
