Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
CHP2
(
calcineurin B homologous protein 2
) was initially identified as a tumor-associated antigen highly expressed in hepatocellular carcinoma. Its biological function remains largely unknown except for a potential role in transmembrane Na(+)/H(+) exchange. In the present study, we observed that ectopic expression of
CHP2
promoted the proliferation of HEK293 cells, whereas knockdown of endogenous
CHP2
expression in HepG2 inhibited cell proliferation. When inoculated into nude mice,
CHP2
transfected HEK293 cells displayed markedly increased oncogenic potential. In analysis of the underlying molecular mechanisms, we found that like calcineurin B,
CHP2
was able to bind to and stimulate the phosphatase activity of
calcineurin
A. In accord with this,
CHP2
-transfected cells showed increased nuclear presence of NFATc3 (nuclear factor of activated T cells) and enhanced NFAT activity. Finally, both accelerated cell proliferation and NFAT activation following
CHP2
transfection could be suppressed by the calcineurin inhibitor cyclosporine A, suggesting an intrinsic connection between these events. Taken together, our results highlighted a potential role of
CHP2
in tumorigenesis and revealed a novel function of
CHP2
as an activator of the
calcineurin
/NFAT signaling pathway.
...
PMID:CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. 1881 28
