Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-25
(
IL-25
) is a recently described T helper 2 (T(H)2) cell-derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T-cell population. Here, we show that mast cells are also potent
IL-25
-producing cells. When bone marrow-derived mast cells were stimulated by immunoglobulin E cross-linking,
IL-25
mRNA was induced within 30 minutes in a
calcineurin
-dependent manner, and the levels of
IL-25
mRNA were comparable with those of activated T(H)2 cells. Production of
IL-25
by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance T(H)2-type immune response by producing
IL-25
.
...
PMID:Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. 1251 10
