Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Deubiquitinating enzymes (DUBs) play an important role in the ubiquitin-proteasome system (UPS) by eliminating ubiquitins from substrates and inhibiting proteasomal degradation. Protein phosphatase methylesterase 1 (PME-1) inactivates protein phosphatase 2A (
PP2A
) and enhances the ERK and Akt signaling pathways, which increase cell proliferation and malignant cell transformation. In this study, we demonstrate that
USP36
regulates PME-1 through its deubiquitinating enzyme activity.
USP36
increases PME-1 stability, and depletion of
USP36
decreases the PME-1 expression level. Furthermore, we demonstrate that
USP36
promotes the ERK and Akt signaling pathways. In summary, it is suggested that
USP36
regulates PME-1 as a DUB and participates in the ERK and Akt signaling pathways.
...
PMID:PME-1 is regulated by USP36 in ERK and Akt signaling pathways. 2957 69
