Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A third form of
protein phosphatase
1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (
protein phosphatase 1G
) or inhibitor-2 (
protein phosphatase
1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.
...
PMID:Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin. 283 Sep 9
We have cloned a novel cDNA from human skeletal muscle which encodes a
protein phosphatase
with a unique acidic domain. It is 34% identical to mammalian PP2C alpha and PP2C beta and we call it
PP2C gamma
. It more closely resembles PP2Cs from Paramecium tetraurelia and Schizosaccharomyces pombe than mammalian PP2Cs. Northern blot analysis shows that
PP2C gamma
is widely expressed, and is most abundant in testis, skeletal muscle, and heart. Like known PP2Cs, recombinant
PP2C gamma
requires Mg2+ or Mn2+ for activity. Unlike any other known phosphatase,
PP2C gamma
has a highly acidic domain: 75% of the 54 residues are glutamate or aspartate.
...
PMID:PP2C gamma: a human protein phosphatase with a unique acidic domain. 927 38
