Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mammalian target of rapamycin complex 1 (mTORC1) kinase is a master regulator of the cellular response to nutrition-related signals such as insulin and amino acids. mTORC1 is activated on the lysosomal membrane and induces phosphorylation of a variety of downstream molecules. We previously showed that activated mTORC1 induces protein phosphatase 2A (
PP2A
)-mediated dephosphorylation of the transcription factor
forkhead box K1
(
FOXK1
). The mechanism underlying the signal transduction from the cytoplasmic mTORC1 to the nuclear
FOXK1
has remained unclear, however, we now show that a nuclear-cytoplasmic transport system is necessary for the mTORC1-
FOXK1
signal transduction. This reaction is mediated by a shuttling protein B56, which is a regulatory subunit of
PP2A
and plays an essential role in the mTORC1-dependent dephosphorylation of
FOXK1
. These results suggest that
PP2A
B56
phosphatase contributes to the signaling for mTORC1-dependent transcriptional regulation.
...
PMID:Nuclear-cytoplasmic shuttling protein PP2A
B56
contributes to mTORC1-dependent dephosphorylation of FOXK1. 2984 97
