Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against
carboxypeptidase A
and
protein phosphatase
1 as well as chymotrypsin, trypsin and thrombin was tested. All anabaenopeptins inhibited
carboxypeptidase A
(apart from one anabaenopeptin variant) and
protein phosphatase
1 with varying potency, but no inhibition against chymotrypsin, trypsin and thrombin was observed.
...
PMID:Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria. 2672 39
