Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We describe here the development of a photoreleasable version of a
protein phosphatase-1
(PP1)-disrupting peptide (
PDP
-
Nal
) that triggers
protein phosphatase-1
activity.
PDP
-
Nal
is a 23 mer that binds to PP1 through several interactions. It was photocaged on a tyrosine residue, which required the exchange of phenylalanine in
PDP
-
Nal
to tyrosine in order to disrupt the most important binding interface. This
PDP
-
caged
can be light-controlled in live cells.
...
PMID:Development of a Photoactivatable Protein Phosphatase-1-Disrupting Peptide. 3184 Oct 1
