Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.16 (
calcineurin
)
17,112
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A novel human dual-specific
protein phosphatase
(DSP), designated
DUSP27
, is here described. The
DUSP27
gene contains three exons, rather than the predicted 4-14 exons, and encodes a 220 amino acid protein.
DUSP27
is structurally similar to other small DSPs, like VHR and DUSP13. The location of
DUSP27
on chromosome 10q22, 50kb upstream of DUSP13, suggests that these two genes arose by gene duplication.
DUSP27
is an active enzyme, and its kinetic parameters and were determined.
DUSP27
is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.
...
PMID:Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. 1749 3
