Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.16 (calcineurin)
 17,112 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vitiligo is a chronic inflammatory skin disease leading to the loss of epidermal melanocytes. To date, treatment options for vitiligo patients are limited, lack sustained efficacy, and are mainly based on off-label use of immunosuppressive agents, such as systemic or topical steroids or topical calcineurin inhibitors, in association with the use of ultraviolet light. However, recent insights into the understanding of the immune pathogenesis of the disease have led to the identification of several therapeutic targets and the development of targeted therapies that are now being tested in clinical trials. In this review, based on the physiopathology of the disease, we summarize emerging targets that could be developed for the treatment of vitiligo and discuss recent and ongoing developments of drugs for the management of the disease.
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PMID:Vitiligo, From Physiopathology to Emerging Treatments: A Review. 3294 37

Vitiligo is an acquired condition which presents as cutaneous depigmentation. There is no licensed treatment for the re-pigmentation of vitiligo lesions, however, several therapies are used routinely and have been studied in clinical trials. These include: topical corticosteroids, calcineurin inhibitors and phototherapy.
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PMID:Ruxolitinib cream for treatment of vitiligo: a randomised, controlled, phase 2 trial: a critical appraisal. 3317 90


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