Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
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Human Gene/Protein
semaphorin B 9.4
transmembrane protein 199 9.4
C1orf19 9.4
TMEM9 protein 9.4
TAP4 9.4
alkaline phosphatase 9.4
DLC-A 9.4
homer homolog 1 9.4
PIGX 9.4
inositoltrisphosphohydrolase 9.4
NF-kappa-B transcription factor p65 9.4
phosphomonoesterase 9.4
LECT1 protein 9.4
BMP-8A 9.4
alkaline phosphomonoesterase 9.4
PERIOSTIN 9.4
Intelectin 1 9.4
Alkaline phosphomonoesterase 8.8
TLAP 8.8
ALPL 8.6
PIGL 8.5
runt-related transcription factor 2 8.4
orf 2 8.4
chondroitinsulfatase 8.4
FAM46A protein 8.4
Cas-interacting zinc finger protein 8.4
tissue-nonspecific ALP 8.4
SATB homeobox 2 8.4
collagen type X alpha 1 8.4
zinc finger protein 42 8.4
coiled-coil domain containing 115 8.4
Peptidyl arginine deiminase, type IV 8.4
triphosphoinositide phosphodiesterase 8.4
LIPM 8.4
SCYA18 8.4
OSTERIX 8.3
TNAP 8.3
Phosphomonoesterase 8.3
osterix 8.3
osteocalcin 8.2
cementum attachment protein 8.1
organic anion transporter 5 8.1
intestinal alkaline phosphatase 8.1
SARG 8.1
Runt-related transcription factor 2 8.0
Alkaline phosphatase 7.9
osteomodulin 7.9
osteopontin, bone sialoprotein 7.9
ZNF346 7.8
ZDHHC12 7.8
Erbb2 interacting protein 7.8
transcription factor GATA-5 7.8
TM6SF2 protein 7.8
SCAMP-4 7.8
BTG4 protein 7.8
PLAP-1 7.8
LIC-2 7.8
Jumonji domain-containing protein 4 7.8
Adenylosuccinate synthase 7.8
distal-less homeobox 2 7.8
CSNK1A1L 7.8
PIGO 7.8
Tumor rejection antigen 7.8
TI60 7.8
PGAP3 7.7
tissue-nonspecific alkaline phosphatase 7.7
bone-type alkaline phosphatase 7.7
cementum protein 1 7.7
placental-like alkaline phosphatase 7.7
PIGV 7.7
ALPI 7.6
LECT1 7.6
dentin sialophosphoprotein 7.6
germ cell alkaline phosphatase 7.6
DMP-1 7.6
glutamate pyruvate transaminase 7.6
bone sialoprotein 7.6
Osteocalcin 7.5
BGP 7.5
ALPP 7.5
more...
Disease
Leontiasis 9.4
High turnover osteopathy 9.4
Primary cholangitis 9.4
infected skin cyst 9.4
Steroid-induced osteopenia 9.4
Adult hypophosphatasia 9.4
Disorder of vitamin D 9.4
Neonatal rickets 9.4
infected skin cyst 9.4
degeneration; spleen 9.4
Childhood hypophosphatasia 9.4
Granulomatous liver disease 9.4
Interstitial pancreatitis 9.4
Neutrophilic leukemia 9.4
hypophosphatasia 8.6
Hyperphosphatasemia 8.6
Severe toxemia 8.4
Chronic active viral hepatitis 8.4
Enzymopathy 8.4
Gingival ulceration 8.4
Eye disorder 8.4
pyelophlebitis 8.4
Leukaemoid 8.4
Cribriform carcinoma 8.4
Organic aciduria 8.4
Gallbladder infection 8.4
craniotabes 8.2
monosomy 1p 7.8
LACH 7.8
Juvenile osteoporosis 7.8
Disseminated paracoccidioidomycosis 7.8
rheumatoidlike arthritis 7.8
IBD4 7.8
Cold Ischemia 7.8
megalocytic anemia 7.8
Looser-Milkman 7.8
Aluminum-related osteomalacia 7.8
Paget's Disease 7.4
Acute gangrenous cholecystitis 7.4
Infection by Opisthorchis viverrini 7.4
Stauffer's syndrome 7.4
Suppurative cholangitis 7.4
acanthocephaliasis 7.4
Pancreatic duct dilatation 7.4
POF4 7.4
Osteosarcoma of bone 7.4
PROA 7.4
Bile duct necrosis 7.4
Biliary fibrosis 7.2
Senile osteoporosis 7.2
Osteopenia of prematurity 7.1
arthritis deformans 7.1
Adema disease 7.1
JPD 7.1
Erythrocytopenia 7.1
Tendon calcification 7.1
Hypotriglyceridemia 7.1
HPE1 7.1
goiter with hyperthyroidism 7.1
infectious arthropathy 7.1
Autosomal dominant osteosclerosis 7.1
Myofibrosarcoma 7.1
CCAL2 7.1
Bone lesion 6.9
HHRH 6.8
Compensated metabolic acidosis 6.8
Erythroid hypoplasia 6.8
Intracortical osteosarcoma 6.8
trichonodosis 6.8
Tick-borne fever 6.8
Secondary biliary cirrhosis 6.8
Adynamic bone disease 6.8
Fibrous dysplasia of bone 6.8
chronic neutrophilic leukemia 6.7
Tick-borne fever 6.7
Cholestatic hepatitis 6.6
phosphaturic mesenchymal tumor 6.6
osteomalacia 6.6
Psoroptic mange 6.6
Regenerative anemia 6.6
more...
Symptom
Temporal headache 9.4
Moist rales 8.4
Pruritus of pregnancy 7.8
Osteoarticular pain 7.8
Left flank pain 7.1
musculoskeletal back pain 6.8
respiratory pain 6.6
Climacteric symptoms 6.4
jaundice of the skin 6.4
Breast tenderness 6.3
phosphatemia 6.2
bone pain 5.9
Gastrointestinal discomfort 5.8
Murphy's sign 5.8
febricula 5.5
Pain and tenderness 5.3
benign congenital hypotonia 5.2
Mucosal hyperplasia 5.1
hepatomegaly 4.9
carpopedal spasm 4.9
Kayser-Fleischer ring 4.8
right upper quadrant pain 4.7
redness of the eyes 4.6
dark urine 4.6
vaginal itching 4.3
Breast pain 4.2
No toxic effect 4.0
male puberty 3.9
musculoskeletal disability 3.9
hepatosplenomegaly 3.8
koilonychia 3.7
rundown 3.7
hypoproteinemia 3.7
emaciation 3.7
Beau's lines 3.6
Severe diarrhea 3.6
Flu-like symptoms 3.6
inanition 3.6
General symptoms 3.5
menopausal symptoms 3.3
asterixis 3.3
prostatism 3.2
splenomegaly 3.2
corpulence 3.1
polyuria 3.0
lumbar back pain 3.0
anorexia 2.9
polydipsia 2.9
Decreased activity 2.9
decreased appetite 2.9
Crawling 2.8
lassitude 2.8
hot flushes 2.8
impaired motor coordination 2.8
Gastrointestinal symptoms 2.8
growing pains 2.8
lethargy 2.8
generalized pain 2.8
night sweats 2.7
bradypnea 2.7
abdominal cramps 2.6
epigastric pain 2.6
chills 2.6
Stiffness 2.6
Spots 2.6
polymyalgia 2.5
Crushing 2.4
mastalgia 2.4
left upper quadrant pain 2.3
asthenia 2.3
photopsia 2.3
body pain 2.3
limb pain 2.3
rigors 2.3
fever of unknown origin 2.3
abdominal pain 2.2
generalized rash 2.2
colic 2.2
leg cramps 2.2
hot flashes 2.1
more...
Drug
Flumetasone 9.4
Skelid 9.4
Fexaramine 9.4
Skelid 9.4
Basaljel 8.4
Anise oil 7.8
Netromycin 7.8
Elsamitrucin 7.8
Liarozole fumarate 7.4
Mentha oil 7.4
L-Homoarginine 7.3
Rocaltrol 7.2
Sudoxicam 7.1
Erythromycin acistrate 7.1
Phosphonopyruvate 7.1
Fosfluconazole 7.1
Parbendazole 7.1
Iodamide 6.8
S-Methylcysteine 6.8
Etidronate disodium 6.8
Epimedium herb 6.6
Netilmicin sulfate 6.6
Cocarboxylase 6.6
Tocopherol acetate 6.6
Calcium acetate 6.6
Actonel 6.6
Iopentol 6.3
Piriprost 6.3
Calcium acetate 6.3
EHDP 6.2
Chrysalin 6.2
Sevelamer hydrochloride 6.1
Levamisol 6.1
Hymenialdisine 6.1
Aquavan 6.1
PTH 6.0
Calcium silicate 6.0
Ipriflavone 6.0
Lactase 5.9
Calcium lactate 5.8
Calcium lactate 5.8
Calcium citrate 5.8
Trimegestone 5.8
Asoprisnil 5.8
Risedronate sodium 5.6
Calcifediol 5.6
NBT 5.5
Cianidanol 5.5
Tolectin 5.5
Ibandronate 5.5
Alfacalcidol 5.4
Amifostine 5.4
Kifunensine 5.4
Salmon calcitonin 5.3
Bonefos 5.3
Citrus unshiu peel 5.3
OP-2 5.3
Ractopamine hydrochloride 5.2
Maxacalcitol 5.2
Ethyol 5.2
Acemannan 5.2
Etoposide phosphate 5.1
Protropin 5.1
Myo-Inositol 5.1
Sulofenur 5.1
Surgibone 5.1
Blenoxane 5.1
CTX 5.0
CFPM 5.0
Vitamin K2 5.0
CTX 5.0
Stannous chloride 5.0
Fosphenytoin 4.9
Heparin sodium 4.9
Cernilton 4.9
Ts-1 4.9
Rocephin 4.8
Fosamax 4.8
Mangafodipir trisodium 4.8
Aredia 4.8
more...
Enzyme
mannonate dehydrogenase 9.4
glycerin-3-phosphate dehydrogenase 9.4
alkaline phosphatase 9.4
EC 1.1.99.10 8.8
chondroitinsulfatase 8.4
dipeptidyl-dipeptidase 8.4
EC 2.3.1.2 8.4
alkyllyso-GP:acetyl-CoA acetyltransferase 7.8
ketogluconate dehydrogenase 7.8
phosphoglycerol transferase 7.6
fructose-2,6-bisphosphate 6-phosphatase 7.4
phosphatidylinositol N-acetylglucosaminyltransferase 7.4
glucose-1-phosphatase 7.4
GPI-PLD 7.3
leucine aminopeptidase 7.2
EC 2.3.2.1 7.2
phosphonoacetate hydrolase 7.1
beta-glycerophosphatase 7.1
uronate isomerase 7.1
ADPR-PPase 7.1
acid phosphatase 7.0
gamma-glutamyl transpeptidase 7.0
sucrase 7.0
venom phosphodiesterase 6.8
nucleotide pyrophosphatase 6.8
EC 3.6.1.28 6.8
hippurate hydrolase 6.8
aspartate aminotransferase 6.8
5'-nucleotidase 6.8
alanine aminopeptidase 6.7
phosphoamidase 6.7
3'(2'),5'-bisphosphate nucleotidase 6.7
PLP phosphatase 6.6
D-galactose dehydrogenase 6.6
glycerophosphate phosphatase 6.6
FAD-AMP lyase 6.6
alanine aminotransferase 6.5
lactase 6.4
nucleotidase 6.3
PHOSPHO1 6.2
7alpha-dehydroxylase 6.2
UDP-sugar hydrolase 6.2
trehalase 6.2
polyphosphatase 6.1
invertase 6.1
p-nitrophenylphosphatase 6.1
guanosine deaminase 6.1
dephospho-CoA kinase 6.0
EC 3.6.1.1 6.0
alpha-glucosidase 6.0
prolinase 5.9
ATP diphosphohydrolase 5.9
aminopeptidase W 5.9
CobS 5.9
sorbitol dehydrogenase 5.9
sucrase-isomaltase 5.9
glycuronidase 5.9
matrix metalloproteinase-20 5.8
heparan-alpha-glucosaminide N-acetyltransferase 5.8
transpeptidase 5.7
lactate dehydrogenase 5.7
proteinase A 5.7
PdxA 5.7
haloacetate dehalogenase 5.7
UDP-N-acetylglucosamine 4-epimerase 5.7
3'-exonuclease 5.6
trimetaphosphatase 5.6
succinic dehydrogenase 5.6
PEP phosphatase 5.6
3beta-HSDH 5.6
polynucleotide kinase 5.6
proprotein convertase 2 5.6
gluconate dehydratase 5.6
glucose-6-phosphatase 5.6
phosphonatase 5.5
alpha-N-acetylglucosaminyl phosphodiesterase 5.5
phosphoinositide 5-phosphatase 5.5
NADH pyrophosphatase 5.5
phosphopentomutase 5.5
PGP phosphatase 5.5
more...
Compound
Fagaronine chloride 9.4
Fexaramine 9.4
Fast Red TR Salt 9.4
CaO-6 9.4
Adenosine 2',5'-bisphosphate 9.4
Eremanthin 9.4
ethyl 4-(1H-indol-3-yl)butanoate 9.4
o-Nitrophenyl beta-D-galactopyranoside 9.4
Naphthol AS-BI 8.6
Nitrophenylphosphate 8.4
Inositol 1,2-cyclic phosphate 8.4
C18H28N5O19P3 8.4
2-deoxypentitol 8.4
1,5-diiodopentane 8.4
butanohydrazide 8.4
Pseudopurpurin 8.4
Gemcadiol 8.4
2-naphthyl laurate 8.4
Calophyllolide 8.4
New Fuchsin 8.2
Fast Red TR 8.1
Deoxypyridinoline 7.9
Alizarin 7.8
Irilone 7.8
Methabenzthiazuron 7.8
Neoeriocitrin 7.8
Piperazine adipate 7.8
Cupressuflavone 7.8
Alizarin Red S 7.7
2-amino-2-methyl-1-propanol 7.5
2-amino-2-methyl-1-propanol 7.4
4-methoxy-1-naphthaldehyde 7.4
4-methylbenzenesulfonohydrazide 7.4
Gum karaya 7.4
Substance B 7.4
Carfentrazone-ethyl 7.4
N'-(4-hydroxy-3-methoxybenzylidene)isonicotinohydrazide 7.4
hydroxymethylphosphonic acid 7.2
Tigogenin 7.1
pentos-2-ulose 7.1
4-nitroso-1-naphthol 7.1
9-acridinecarboxylic acid 7.1
Hyocholic acid 7.1
C6H5NO3 7.1
Tiludronate 7.1
Poncirin 7.1
pentos-2-ulose 7.1
Sciadopitysin 7.1
3,5-dichloro-2-hydroxybenzenesulfonic acid 7.1
ALP 7.0
25,26-dihydroxyvitamin D 7.0
Monotropein 6.9
DNPP 6.9
Colchiceine 6.8
C12H10O2 6.8
5-Methylthioribose 6.8
4-methoxy-1-naphthaldehyde 6.8
Colchiceine 6.8
Pyrazine diazohydroxide 6.6
Diaveridine 6.6
Hyocholic acid 6.6
4-methylbenzenesulfonohydrazide 6.6
6-ECDCA 6.6
4-amino-2,6-dichlorophenol 6.6
Sulfobromophthalein 6.5
4-amino-1-naphthol 6.5
Pamidronate 6.5
Ponceau S 6.4
2-Deoxy-D-galactose 6.4
Heliotrine 6.4
bicyclo[2.2.1]heptan-2-one 6.4
5,10-dihydroindeno[1,2-b]indole 6.4
2,3-heptanedione 6.4
Violuric acid 6.4
WR-1065 6.3
Alendronate 6.3
Lead nitrate 6.3
Methidathion 6.3
2,4-DA 6.3
Di-n-butyltin dichloride 6.3
more...