Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
47,916 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
alkaline phosphatase 47441
osteocalcin 4989
osteogenic 4365
collagen 3347
Sep 3234
aspartate aminotransferase 3151
alanine aminotransferase 2307
acid phosphatase 2118
lactate dehydrogenase 1970
Mol 1891
albumin 1833
parathyroid hormone 1744
type I collagen 1441
osteopontin 1359
phosphatase 1216
catalase 1120
superoxide dismutase 1112
Alkaline phosphatase 1062
ALP 833
ATP 805
BMP-2 800
bone morphogenetic protein 800
peroxidase 777
hemoglobin 740
bone sialoprotein 712
ATPase 702
insulin 701
brush border 667
PTH 659
glutathione peroxidase 631
tartrate-resistant acid phosphatase 616
serum albumin 593
GSH 586
gamma-glutamyl transpeptidase 586
osteosarcoma 563
esterase 507
5'-nucleotidase 496
gamma-glutamyltransferase 489
osteoprotegerin 482
calcitonin 475
creatine kinase 462
amylase 455
runt-related transcription factor 2 417
tumor necrosis factor 413
TNF 406
RUNX2 403
SDS 396
cytokine 394
osterix 392
Osteocalcin 391
lysozyme 380
AST 379
fused 371
AMP 365
endoplasmic reticulum 361
leucine aminopeptidase 352
membrane-bound 336
glycoprotein 332
osteonectin 326
fibronectin 324
gut 319
phosphomonoesterase 318
catenin 309
polypeptide 309
RANKL 306
IL-6 300
phosphodiesterase 292
LDH 287
lipopolysaccharide 287
glutamate pyruvate transaminase 280
prothrombin 279
lipase 275
beta-glucuronidase 274
intestinal alkaline phosphatase 274
CTX 269
lactase 269
p38 256
collagenase 254
vascular endothelial growth factor 249
myeloperoxidase 248
more...
Disease
osteoporosis 1992
cancer 1826
tumor 1604
bone disease 680
cholestasis 658
osteosarcoma 616
diabetes 608
hyperparathyroidism 595
GSH 586
liver disease 585
carcinoma 535
metastases 512
cirrhosis 503
osteomalacia 455
PDB 449
SDS 396
hepatitis 387
hypercalcemia 381
rickets 373
hypophosphatasia 348
anemia 345
breast cancer 341
hepatocellular carcinoma 334
SEM 318
primary biliary cirrhosis 289
leukemia 280
prostate cancer 273
CTX 271
cholangitis 264
pruritus 259
vitamin D deficiency 258
chronic renal failure 251
bone metastases 240
adenocarcinoma 234
hypertension 220
rheumatoid arthritis 212
primary hyperparathyroidism 206
cold 188
renal disease 188
renal osteodystrophy 185
HIV 182
depression 181
renal failure 181
TCP 179
osteoarthritis 179
multiple myeloma 177
lymphoma 172
thrombocytopenia 170
obesity 168
Best 166
sepsis 164
hepatitis B 160
ash 159
periosteum 158
uterus 156
arthritis 146
atherosclerosis 145
BMD 145
carcinogenesis 142
chronic myeloid leukemia 141
liver fibrosis 141
chronic hepatitis 138
hepatitis C 136
sepsis 136
cytomegalovirus 133
fatty liver 128
immunodeficiency 127
dysplasia 127
PCL 125
Alzheimer's disease 124
hyperthyroidism 123
hyperglycemia 123
gallstones 122
viral hepatitis 122
primary sclerosing cholangitis 119
pancreatitis 119
type 2 diabetes 118
periodontitis 117
colon cancer 117
hyperbilirubinemia 117
more...
Symptom
pain 519
diarrhea 294
bone pain 279
hepatomegaly 258
abdominal pain 219
weakness 190
fatigue 184
vomiting 168
anorexia 160
splenomegaly 136
starvation 134
anesthesia 121
seizures 119
nausea 113
hepatosplenomegaly 93
headache 65
lethargy 58
back pain 54
Ill 53
arthralgia 42
dyspnea 40
chills 39
collapse 38
polyuria 38
constipation 36
nausea and vomiting 35
thinning 34
myalgia 33
epigastric pain 32
discomfort 30
overweight 30
low back pain 30
discomfort 30
respiratory distress 28
cough 28
distraction 27
hypotonia 27
flushing 27
right upper quadrant pain 26
erythema 25
polydipsia 25
menopausal symptoms 25
ataxia 23
hypoproteinemia 22
colic 22
asthenia 20
emaciation 20
dizziness 20
insomnia 19
agitation 18
exhaustion 17
hypothermia 17
acidity 16
cachexia 16
fever of unknown origin 15
chest pain 14
sleepiness 13
hot flushes 13
decreased appetite 13
phosphatemia 12
regurgitation 12
night sweats 12
pallor 12
angina 12
abdominal discomfort 11
tremor 11
dark urine 10
acute abdominal pain 10
analgesia 10
leg pain 10
paresthesia 10
rundown 10
hyperoxia 10
Stiffness 9
hip pain 8
numbness 8
Wind 8
hot flashes 7
dysuria 7
acute stress 6
more...
Drug
PTH 670
CTX 299
ascorbate 279
CTX 269
CTX 269
lysine 219
vitamin E 175
ROS 165
Dermatol 127
NADH 126
Dial 93
NBT 91
lactose 89
Gel 85
CSF 69
Monit 68
Nephron 66
TiO2 62
Nephron 58
EHDP 56
MAP 56
Ethanol 55
ICI 55
ZnO 53
Leaf 53
caffeine 51
IL-2 48
Albumin 47
EE2 46
DNase I 45
ABC 43
Retinoic acid 42
Cardiovasc 37
Serum albumin 36
citric acid 33
ROC 33
Fluorescein 33
Glutathione 33
Gelatin 33
CaCl2 32
Zoledronic acid 32
CaCl2 31
CaCl2 31
NAG 31
IFN-gamma 31
APD 31
Simvastatin 30
Asn 29
Vitamin E 28
pyridoxal phosphate 28
SiO2 27
G418 25
Indomethacin 25
Lactase 25
MRC 25
Alanine 24
Pronase 24
Amifostine 23
ampicillin 23
ZnCl2 22
ZnCl2 22
Prednisolone 22
Fluorescein 22
Paraffin 22
Activin 21
Vitamin K 21
Adriamycin 20
G-CSF 19
ALA 19
PDL 19
Raloxifene 19
Bifidobacterium 19
CDP 18
Mutagen 18
Growth hormone 18
Growth hormone 18
Vitamin B 17
Zoledronic acid 17
HCG 16
Glycyrrhiza 16
more...
Enzyme
alkaline phosphatase 47916
alanine aminotransferase 3647
aspartate aminotransferase 3559
acid phosphatase 2507
lactate dehydrogenase 2278
gamma-glutamyl transpeptidase 1743
superoxide dismutase 1177
catalase 1165
peroxidase 1109
ATPase 957
glutathione peroxidase 637
creatine kinase 613
protein kinase 613
mitogen-activated protein kinase 549
5'-nucleotidase 517
invertase 504
sucrase 455
acetylcholinesterase 432
ERK 418
alpha-glucosidase 399
lysozyme 390
AST 378
trypsin 364
leucine aminopeptidase 360
phosphodiesterase 359
beta-galactosidase 359
succinate dehydrogenase 301
lipase 285
cholinesterase 281
collagenase 275
protein kinase C 269
luciferase 268
lactase 264
beta-glucuronidase 261
phospholipase C 254
urease 241
urease 240
CD13 231
glucose-6-phosphatase 220
glutathione reductase 209
glutathione S-transferase 205
glucose-6-phosphate dehydrogenase 190
reverse transcriptase 168
adenylate cyclase 164
neuraminidase 162
RNase 160
ACS 160
RNase 156
glutamate dehydrogenase 142
glutamate dehydrogenase 142
glutamate dehydrogenase 141
focal adhesion kinase 137
calcineurin 135
caspase-3 135
succinic dehydrogenase 129
nucleotidase 125
phospholipase A2 125
malate dehydrogenase 123
transpeptidase 117
alanine aminopeptidase 117
cathepsin K 104
chymotrypsin 103
AMPK 99
DNase 99
beta-glucosidase 97
sorbitol dehydrogenase 97
trehalase 97
sulfatase 97
thrombin 97
prostate-specific antigen 95
alpha-amylase 95
ceruloplasmin 94
aldolase 94
hyaluronidase 91
RNA polymerase 91
diaphorase 87
thromboplastin 86
phytase 83
phytase 83
beta-glucosidase 80
more...
Compound
calcium 7240
phosphate 5163
Dec 3301
Clin 3215
DNA 2952
creatinine 2281
glucose 2122
phosphorus 2095
sodium 2088
urea 1748
water 1655
vitamin D 1310
nitrogen 1098
zinc 1050
ALP 833
ATP 806
oxygen 801
alanine 757
sulfate 713
potassium 699
titanium 675
GSH 612
GSH 612
acetate 611
iron 574
MTT 502
ethanol 476
salt 447
cAMP 440
SDS 429
Mg2+ 425
TNF 406
copper 404
AMP 398
galactose 386
Alizarin 383
Phe 369
nitric oxide 358
arginine 352
leucine 343
serine 329
lysine 309
EDTA 309
EDTA 308
CTX 299
tyrosine 295
retinoic acid 278
His 260
hydrogen 260
cysteine 257
carbonate 257
cadmium 256
GPT 247
silver 235
PEG 229
CCl4 218
bromide 214
Triton X-100 210
Collagen 209
proline 207
threonine 207
methionine 204
glutamate 201
ammonium 198
ADP 194
manganese 191
aluminum 190
glycerol 189
Vitamin D 186
TCP 179
TCP 179
TCP 179
TCP 179
nitrate 177
ADP 176
ADP 176
PEG 174
DEAE 169
CO2 168
Asp 162
more...