Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.3.1 (
alkaline phosphatase
)
47,916
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
alkaline phosphatase
47441
osteocalcin
4989
osteogenic
4365
collagen
3347
Sep
3234
aspartate aminotransferase
3151
alanine aminotransferase
2307
acid phosphatase
2118
lactate dehydrogenase
1970
Mol
1891
albumin
1833
parathyroid hormone
1744
type I collagen
1441
osteopontin
1359
phosphatase
1216
catalase
1120
superoxide dismutase
1112
Alkaline phosphatase
1062
ALP
833
ATP
805
BMP-2
800
bone morphogenetic protein
800
peroxidase
777
hemoglobin
740
bone sialoprotein
712
ATPase
702
insulin
701
brush border
667
PTH
659
glutathione peroxidase
631
tartrate-resistant acid phosphatase
616
serum albumin
593
GSH
586
gamma-glutamyl transpeptidase
586
osteosarcoma
563
esterase
507
5'-nucleotidase
496
gamma-glutamyltransferase
489
osteoprotegerin
482
calcitonin
475
creatine kinase
462
amylase
455
runt-related transcription factor 2
417
tumor necrosis factor
413
TNF
406
RUNX2
403
SDS
396
cytokine
394
osterix
392
Osteocalcin
391
lysozyme
380
AST
379
fused
371
AMP
365
endoplasmic reticulum
361
leucine aminopeptidase
352
membrane-bound
336
glycoprotein
332
osteonectin
326
fibronectin
324
gut
319
phosphomonoesterase
318
catenin
309
polypeptide
309
RANKL
306
IL-6
300
phosphodiesterase
292
LDH
287
lipopolysaccharide
287
glutamate pyruvate transaminase
280
prothrombin
279
lipase
275
beta-glucuronidase
274
intestinal alkaline phosphatase
274
CTX
269
lactase
269
p38
256
collagenase
254
vascular endothelial growth factor
249
myeloperoxidase
248
more...
Disease
osteoporosis
1992
cancer
1826
tumor
1604
bone disease
680
cholestasis
658
osteosarcoma
616
diabetes
608
hyperparathyroidism
595
GSH
586
liver disease
585
carcinoma
535
metastases
512
cirrhosis
503
osteomalacia
455
PDB
449
SDS
396
hepatitis
387
hypercalcemia
381
rickets
373
hypophosphatasia
348
anemia
345
breast cancer
341
hepatocellular carcinoma
334
SEM
318
primary biliary cirrhosis
289
leukemia
280
prostate cancer
273
CTX
271
cholangitis
264
pruritus
259
vitamin D deficiency
258
chronic renal failure
251
bone metastases
240
adenocarcinoma
234
hypertension
220
rheumatoid arthritis
212
primary hyperparathyroidism
206
cold
188
renal disease
188
renal osteodystrophy
185
HIV
182
depression
181
renal failure
181
TCP
179
osteoarthritis
179
multiple myeloma
177
lymphoma
172
thrombocytopenia
170
obesity
168
Best
166
sepsis
164
hepatitis B
160
ash
159
periosteum
158
uterus
156
arthritis
146
atherosclerosis
145
BMD
145
carcinogenesis
142
chronic myeloid leukemia
141
liver fibrosis
141
chronic hepatitis
138
hepatitis C
136
sepsis
136
cytomegalovirus
133
fatty liver
128
immunodeficiency
127
dysplasia
127
PCL
125
Alzheimer's disease
124
hyperthyroidism
123
hyperglycemia
123
gallstones
122
viral hepatitis
122
primary sclerosing cholangitis
119
pancreatitis
119
type 2 diabetes
118
periodontitis
117
colon cancer
117
hyperbilirubinemia
117
more...
Symptom
pain
519
diarrhea
294
bone pain
279
hepatomegaly
258
abdominal pain
219
weakness
190
fatigue
184
vomiting
168
anorexia
160
splenomegaly
136
starvation
134
anesthesia
121
seizures
119
nausea
113
hepatosplenomegaly
93
headache
65
lethargy
58
back pain
54
Ill
53
arthralgia
42
dyspnea
40
chills
39
collapse
38
polyuria
38
constipation
36
nausea and vomiting
35
thinning
34
myalgia
33
epigastric pain
32
discomfort
30
overweight
30
low back pain
30
discomfort
30
respiratory distress
28
cough
28
distraction
27
hypotonia
27
flushing
27
right upper quadrant pain
26
erythema
25
polydipsia
25
menopausal symptoms
25
ataxia
23
hypoproteinemia
22
colic
22
asthenia
20
emaciation
20
dizziness
20
insomnia
19
agitation
18
exhaustion
17
hypothermia
17
acidity
16
cachexia
16
fever of unknown origin
15
chest pain
14
sleepiness
13
hot flushes
13
decreased appetite
13
phosphatemia
12
regurgitation
12
night sweats
12
pallor
12
angina
12
abdominal discomfort
11
tremor
11
dark urine
10
acute abdominal pain
10
analgesia
10
leg pain
10
paresthesia
10
rundown
10
hyperoxia
10
Stiffness
9
hip pain
8
numbness
8
Wind
8
hot flashes
7
dysuria
7
acute stress
6
more...
Drug
PTH
670
CTX
299
ascorbate
279
CTX
269
CTX
269
lysine
219
vitamin E
175
ROS
165
Dermatol
127
NADH
126
Dial
93
NBT
91
lactose
89
Gel
85
CSF
69
Monit
68
Nephron
66
TiO2
62
Nephron
58
EHDP
56
MAP
56
Ethanol
55
ICI
55
ZnO
53
Leaf
53
caffeine
51
IL-2
48
Albumin
47
EE2
46
DNase I
45
ABC
43
Retinoic acid
42
Cardiovasc
37
Serum albumin
36
citric acid
33
ROC
33
Fluorescein
33
Glutathione
33
Gelatin
33
CaCl2
32
Zoledronic acid
32
CaCl2
31
CaCl2
31
NAG
31
IFN-gamma
31
APD
31
Simvastatin
30
Asn
29
Vitamin E
28
pyridoxal phosphate
28
SiO2
27
G418
25
Indomethacin
25
Lactase
25
MRC
25
Alanine
24
Pronase
24
Amifostine
23
ampicillin
23
ZnCl2
22
ZnCl2
22
Prednisolone
22
Fluorescein
22
Paraffin
22
Activin
21
Vitamin K
21
Adriamycin
20
G-CSF
19
ALA
19
PDL
19
Raloxifene
19
Bifidobacterium
19
CDP
18
Mutagen
18
Growth hormone
18
Growth hormone
18
Vitamin B
17
Zoledronic acid
17
HCG
16
Glycyrrhiza
16
more...
Enzyme
alkaline phosphatase
47916
alanine aminotransferase
3647
aspartate aminotransferase
3559
acid phosphatase
2507
lactate dehydrogenase
2278
gamma-glutamyl transpeptidase
1743
superoxide dismutase
1177
catalase
1165
peroxidase
1109
ATPase
957
glutathione peroxidase
637
creatine kinase
613
protein kinase
613
mitogen-activated protein kinase
549
5'-nucleotidase
517
invertase
504
sucrase
455
acetylcholinesterase
432
ERK
418
alpha-glucosidase
399
lysozyme
390
AST
378
trypsin
364
leucine aminopeptidase
360
phosphodiesterase
359
beta-galactosidase
359
succinate dehydrogenase
301
lipase
285
cholinesterase
281
collagenase
275
protein kinase C
269
luciferase
268
lactase
264
beta-glucuronidase
261
phospholipase C
254
urease
241
urease
240
CD13
231
glucose-6-phosphatase
220
glutathione reductase
209
glutathione S-transferase
205
glucose-6-phosphate dehydrogenase
190
reverse transcriptase
168
adenylate cyclase
164
neuraminidase
162
RNase
160
ACS
160
RNase
156
glutamate dehydrogenase
142
glutamate dehydrogenase
142
glutamate dehydrogenase
141
focal adhesion kinase
137
calcineurin
135
caspase-3
135
succinic dehydrogenase
129
nucleotidase
125
phospholipase A2
125
malate dehydrogenase
123
transpeptidase
117
alanine aminopeptidase
117
cathepsin K
104
chymotrypsin
103
AMPK
99
DNase
99
beta-glucosidase
97
sorbitol dehydrogenase
97
trehalase
97
sulfatase
97
thrombin
97
prostate-specific antigen
95
alpha-amylase
95
ceruloplasmin
94
aldolase
94
hyaluronidase
91
RNA polymerase
91
diaphorase
87
thromboplastin
86
phytase
83
phytase
83
beta-glucosidase
80
more...
Compound
calcium
7240
phosphate
5163
Dec
3301
Clin
3215
DNA
2952
creatinine
2281
glucose
2122
phosphorus
2095
sodium
2088
urea
1748
water
1655
vitamin D
1310
nitrogen
1098
zinc
1050
ALP
833
ATP
806
oxygen
801
alanine
757
sulfate
713
potassium
699
titanium
675
GSH
612
GSH
612
acetate
611
iron
574
MTT
502
ethanol
476
salt
447
cAMP
440
SDS
429
Mg2+
425
TNF
406
copper
404
AMP
398
galactose
386
Alizarin
383
Phe
369
nitric oxide
358
arginine
352
leucine
343
serine
329
lysine
309
EDTA
309
EDTA
308
CTX
299
tyrosine
295
retinoic acid
278
His
260
hydrogen
260
cysteine
257
carbonate
257
cadmium
256
GPT
247
silver
235
PEG
229
CCl4
218
bromide
214
Triton X-100
210
Collagen
209
proline
207
threonine
207
methionine
204
glutamate
201
ammonium
198
ADP
194
manganese
191
aluminum
190
glycerol
189
Vitamin D
186
TCP
179
TCP
179
TCP
179
TCP
179
nitrate
177
ADP
176
ADP
176
PEG
174
DEAE
169
CO2
168
Asp
162
more...