Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The changes in blood serum concentrations of calcium, magnesium, inorganic phosphate, total activity of alkaline phosphatase and the activity of its bone fraction, as well as urinary excretion of calcium, phosphate, hydroxyproline and oxalate have been measured in 31 patients with insulin-dependent (type I) diabetes, in 31 patients with non-insulin-dependent (type II) diabetes and in 29 healthy subjects in the condition of low-calcium diet. The elevated urinary excretion of calcium, phosphate, hydroxyproline and oxalate, lowered blood serum level of magnesium, and increased total and bone fraction activities of alkaline phosphatase were found in diabetic patients. The urinary excretion of calcium and hydroxyproline, and the activity of bone fraction alkaline phosphatase were significantly higher in patients with type II diabetes than in those with type I diabetes. It was concluded that there is a significant relation between the state of metabolic normalization of diabetes and the degree of biochemical aberrations concerning calcium-phosphate metabolism.
Endokrynol Pol 1989
PMID:[Selected indicators of calcium-phosphate metabolism in patients with diabetes mellitus]. 264 14

A group of 72 patients with chronic renal failure (22 non-dialysed and 50 hemodialysed) were studied for the behaviour of the threshold of vibratory sensibility in upper and lower limbs at frequencies of 125 and 250 Hz. The patients dialysed were examined just before hemodialysis. All the patients were studied for the following parameters: concentration of calcium, inorganic phosphates, PTH, creatinine, uric acid in the blood serum and the activity of general alkaline phosphatase and its thermolabile fraction (osseous). The patients dialysed differed from the patients non-dialysed in higher creatinine, uricemia and the activity of alkaline phosphatase, both general and its "osseous" fraction. But they did not differ significantly in the concentration of phosphates, PTH and calcemia . Two thirds of patients with chronic renal failure, both dialysed and non-dialysed, revealed a significant increase in the threshold of vibratory sensibility, better marked in lower limbs then in upper limbs. As opposed to patients non-dialysed, patients dialysed did not show a significant correlation between the level of PTH in blood serum and the threshold of vibratory sensibility. Dialysotherapy did not influence significantly the frequency of disorders in vibratory sensibility. Considering the fact of almost identical frequency of disorders in vibratory sensibility both in patients dialysed and non-dialysed and also the lack of correlation between the level of lesion of vibratory sensibility and the concentration of PTH in blood serum, the participation of parathormone in the pathogenesis of uremic neuropathy seems to be doubtful.
Pol Arch Med Wewn
PMID:[Study of vibration sensation in the aspect of disorders of calcium-phosphate metabolism in patients with chronic renal failure]. 264 22

From January 1987 to April 1988 six children we studied cytologically with the use of alkaline phosphatase-anti-alkaline phosphatase (APAAP) method and monoclonal antibodies (MoP) in order to establish the diagnosis of Non-Hodgkin Lymphoma. (NHL). Cytologic studies concerned pleural fluid (3 patients) imprints of the lymph node (3 patients), bone marrow smears (2 patients) and cerebrospinal fluid (1 patient). We performed simultaneously routine cytologic and histopathologic studies of the lymph nodes. Antigen T6 (thymocytes) was present in blasts of all patients, which permitted us to classify the blasts as common stage II group according to Reinherz. In all cases we found at least two positive antigen detected by MoP pan T (CD2, CD3, CD5, CD7) in one case--no expression of antigen T3 (CD3) and in two cases no antigen detected by an antibody CD2. Antigen Ia was found in one patient, and weak expression of antigen CALLA (CD10) in one patients. In three patients we showed a simultaneous expression of antigens T4, T8, whereas in two patients they were not observed. One child possessed mature phenotype T4, T6. By using APAAP method with MoP in cytologic studies it was possible to diagnose T-lymphoblastic lymphoma in six children before the results of histopathologic examination of the lymph nodes.
Patol Pol 1989
PMID:[Use of an immunoenzyme method with monoclonal antibodies in cytologic studies for the optimal diagnosis of non-Hodgkin's lymphoma in children]. 270 31

Twenty-five samples obtained by amniocentesis were studied in 25 pregnant women between 35 and 40 weeks of pregnancy with hypertension. The following biochemical investigations were done in the samples: total protein, beta-lipoproteins, cholesterol, uric acid, urea, creatinine, AlAT and AspAT, total alkaline phosphatase and its thermostable isoenzyme, ceruloplasmin and alpha-amylase. The results were analysed in relation to the development of the respiratory distress syndrome in the newborn and were subjected to statistical analysis. In the amniotic fluid of hypertensive mothers in whose children the respiratory distress syndrome developed, reduction was found in the concentrations of beta-lipoproteins and cholesterol. This may have a prognostic significance in the prediction of respiratory distress in early neonatal period.
Ginekol Pol
PMID:[Respiratory distress in newborns born to hypertensive mothers and protein, lipid and renal maturity indices and enzymatic activity in the amniotic fluid]. 270 91

This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase (A1AT) and bilirubin level in serum in comparison with rats with GalN-damaged liver but without DS treatment. In summary, DS exacerbates a damage of the liver of rats. This study supported the clinical observations showing enhanced liver damage in alcoholics treated with DS.
Pol J Pharmacol Pharm
PMID:Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis. 309 1

Deformations of skeleton have appeared in 40.0% of rams and in 10.0% of ewes 9 months old fed concentrates and libitum. The ration of Ca:P in a daily fed ration was 0.832:1.0. The contend of Ca in sera of sick animals was normal, however, the level of inorganic P was elevated by 12.32 mg/100 ml in young rams and by 11.20 g/100 ml in young ewes. The activity of alkaline phosphatase exceeded almost three times the normal value of this enzyme and it reached 44.6 K-A in young rams and 32.8 i K-A in young ewes. In control 9 months old sheep under controlled feeding the content of the examined minerals and activity of alkaline phosphatase were in normal limits. It was found a statistically significant difference in the content of inorganic P and the activity of alkaline phosphatase in experimental and control animals. It was corrected feeding of the experimental sheep in which successive examinations performed at the age of 12 and 18 months did not reveal statistically significant differences in comparison to control animals. The increase of the activity of alkaline phosphatase in 9 months old experimental sheep is the result of disturbances in Calcium-Phosphorus balance due to unproper mineral feeding.
Pol Arch Weter 1986
PMID:[Serum calcium, inorganic phosphorus and alkaline phosphatase levels in sheep with deformities of the extremities]. 362 Mar 77

The activity of lysosomatic enzymes, i.e.: alkaline phosphatase, beta-glucoronidase, lysozyme and non-specific alfa-esterase in the organic lymphocytes and in the lymphocytes of peripheral blood were determined. It was found that the disorders of intracellular distribution of enzymes are the evidence of destabilization of lysozymes membrane with the following translocation of alkaline hydrolases into cytoplasm. There were observed the debilitation of the protective possibilities and the decrease of unspecific immunological resistance of leukaemia lymphocytes.
Pol Arch Weter 1986
PMID:[Lysosomal enzymes in lymphocytes in experimental lymphatic leukemia in mice]. 362 Mar 79

Rat duodenum and jejunum were found to contain three forms of alkaline phosphatase, F1, F2 and F3, and ileum two forms of this enzyme, F1 and F2. The procedure for separation of phosphatase F1, F2 and F3 from jejunum is presented.
Acta Biochim Pol 1986
PMID:Molecular forms of alkaline phosphatase in particular segments of the small intestine of adult rat. Separation of three enzyme forms from jejunum. 382

The effect of heating, urea and L-homoarginine on the total activity of serum alkaline phosphatase was investigated in pigs of Akp B, Akp BC and Akp A phenotypes. Each of these factors decreased the activity of the enzyme, but under the experimental conditions applied the effect exerted by L-homoarginine was weakest. Statistically significant differences were demonstrated in the degree of action of each factor in different phenotypes of the animals. It was observed that urea as well as heating decreased the total activity of serum alkaline phosphatase in B-phenotype animals more than in animals of BC and AB phenotypes.
Acta Physiol Pol
PMID:Differentiated influence of heating and certain chemical agents on serum alkaline phosphatase activity in pigs. 618 21

Alkaline phosphate, catalase and beta-galactosidase activities of Vibrio et tor were decreased after acquisition of resistance towards rifampicin. Zn2+, Mn2+ and EDTA inhibited alkaline phosphatase which is most active with p-nitrophenylphosphate as substrate while Mg2+ was found to suppress alkaline phosphatase activity. Removal of EDTA however, restores the original activity. Rifampicin could not induce mutation of lactose nonfermenting Vibrio el for cells allowing them to grow on lactose as sole carbon source, z-galactosidase which is a constitutive enzyme in this case is repressed by glucose. This repression is overcome by cAMP.
Acta Microbiol Pol 1982
PMID:Studies on alkaline phosphatase, catalase and z-galactosidase in Vibrio el tor under normal and rifampicin resistant conditions. 618 76


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