Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum concentrations of bile acids and bilirubin, and activity of alanine transferase and alkaline phosphatase as well as bile acid and bilirubin levels in duodenal contents were determined in 90 infants aged 1-44 weeks (including 49 under 10 weeks of age) admitted to hospital for prolonged jaundice. Infants with extrahepatic cholestasis were found to have statistically higher serum bile acid and bilirubin concentrations. Oral administration of cholestyramine produced a statistically significant decrease in serum bile acids and bilirubin in infants with intrahepatic cholestasis under 10 weeks of age. In 24 out of the 30 infants with biliary tract obstruction total absence of bile acids in the duodenal contents was demonstrated while in the others the concentration did not exceed 0.2 mmol/l. The mean bile acid concentration in infants with intrahepatic cholestasis was 2.81 mmol/l while in 8 infants out of the 60 bile acids were either absent or present in trace amounts. The method had an 84.4% sensitivity.
Mater Med Pol
PMID:Value of bile acid determination for the diagnosis of neonatal jaundice. 210 73

Cyclophosphamide administered intraperitoneally in 20 mg/kg doses at intervals of six days for six weeks caused focal morphological and histochemical lesions of low intensity in rat myocardium. From the third week of the experiment focal eosinophilia and fuchsinophilia of the cytoplasm of a part and later on, of the whole cytoplasm of myocardial fibres, contraction nodes, undulant shape of the fibres, rupture of intercalated discs, very rarely in the sixth week small focal infiltrations composed of mononuclear cells at the site of damaged and disintegrated myocardial fibres, small amount of glycogen, focal increase of acid phosphatase activity and low-grade loss of alkaline phosphatase and magnesium and calcium-dependent ATPases in the sixth week, and unchanged activity of succinic dehydrogenase. Simultaneous use of cyclophosphamide and low-magnesium diet increased the intensity of degenerative changes, which appeared from the second week on, and necrotic changes appearing from the third week on, with more pronounced disturbances in the activity of all studied enzymes, including succinic dehydrogenase, in the sixth week.
Mater Med Pol
PMID:Histological and histochemical examinations of the myocardium of rats kept on low-magnesium diet and treated with cyclophosphamide. 213 21

The influence was studied of the type of immunosuppression on calciuria, phosphaturia, and on the levels of parathyroid hormone (PTH), calcitonin (CT), 25-hydroxycholecalciferol (25/OH/D), total calcium, magnesium, and alkaline phosphatase activity in 24 patients after renal transplantation. Twelve of these patients received cyclosporin with prednisone (group CyA) and other 12 were treated with azathioprine and prednisone (group Aza). Independently of the type of immunosuppression used, in both groups a significantly higher concentration of PTH, CT, 25/OH/D and greater activity of alkaline phosphatase were demonstrated in relation to healthy controls. In both studied groups the patients had also a significantly reduced calciuria and phosphatemia than controls. In group Aza the patients had a significantly lower phosphaturia and significantly higher magnesemia than in group CyA. The results of these investigations suggest a certain influence of the type of immunosuppression on the intensity of calcium-phosphate metabolism in renal graft recipients.
Pol Arch Med Wewn 1990 Mar
PMID:[Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]. 221 34

In 34 patients (16 women and 18 men) with acute leukaemias (8 with acute lymphoblastic leukaemia and 26 with acute myeloblastic leukaemia), as yet untreated, the serum levels were determined of conjugated cholic acid, bilirubin, aspartate aminotransferase (AspAT), alanine aminotransferase (AlAT), alkaline phosphatase (AP), lactate dehydrogenase (LDH) and cholinesterase (Chol). Serum conjugated cholic acid level was determined by radioimmunoassay. The mean values of AP and Chol activity were within the range of normal values in this laboratory, the values of AspAT and AlAT were slightly above this range, and LDH value exceeded twice this normal range. The mean bilirubin concentration was within normal range. The greatest changes were noted in conjugated cholic acid values, the mean value exceeded five times the upper normal range (1.0 mumol/l). In 30 patients (88%) the conjugated cholic acid level in the serum was above 1.0 mumol/l, in the remaining 4 cases it was above the mean value for the control group. No correlation was found between conjugated cholic acid and any of the determined parameters. These results point out that the serum level of conjugated cholic acid may be a valuable parameter for assessment of hepatocellular function in acute leukaemias.
Pol Arch Med Wewn
PMID:[Serum cholic acid levels in patients with acute leukemia]. 225 Dec 7

Three patients with amyloidosis in whom hepatomegaly was the main sign ara presented. In all cases jaundice coexisted which is regarded as a rare sign in amyloidosis. Attention is called to the diagnostic difficulties of amyloidosis especially without a preceding clinically overt disease process. The presence of a particularly high activity of alkaline phosphatase in the serum, and focal absence of 99Tc uptake by the hepatic macrophage system in liver scintigram suggested liver tumour. However, demonstration of monoclonal protein in blood, urine or ascitic fluid, or raised level of alpha 2 globulin, should call attention to the possibility of liver amyloidosis. The authors stress the usefulness of the method of preincubation of tissue biopsy specimens in potassium hypermanganate during routine staining with Congo red for differentiation of amyloid AA from amyloid AL.
Pol Arch Med Wewn 1990 Sep
PMID:[Diagnostic difficulties in hepatic amyloidosis--clinical analysis and autopsy data of 3 cases]. 226 76

In male Wistar rats the protective effect of Padma 28 against changes induced by prolonged treatment with ethyl alcohol was investigated. Exposure of the animals to prolonged ethyl alcohol consumption caused a significant increase in AspAT (by 32%), A1AT (by 50%) and alkaline phosphatase (by 372%) activities as well as an increase in the levels of bilirubin (by 98%) and lipids in the blood serum and lipids in the liver homogenate. Padma 28 administration was found to exert a protective action against these changes: a significant reduction of blood total lipid, triacylglycerol, total cholesterol and bilirubin concentrations as well as in the activity of the liver enzymes was observed.
Acta Physiol Pol
PMID:Inhibition of ethanol-induced changes in rats by Padma 28. 248 10

Blasts phenotype was determined in 61 children with the acute lymphoblastic leukemia. Non-T-cell acute lymphoblastic leukemia was diagnosed in 51 children. Stages of blasts differentiation were determined with the aid of monoclonal antibodies set using alkaline phosphatase-anti-alkaline phosphatase technique. Blasts in 50 patients belonged to B subpopulation confirmed by the presence of panB CD19 and CD22 antigens. Common antigen was seen in 76.5% of the examined patients with non-T-cell acute lymphoblastic leukemia. Cases of non-T-cell acute lymphoblastic leukemia were divided into 8 subgroups depending on the antigens of B-cells differentiation. An identification of pre-B subgroups of the acute lymphoblastic leukemia indicates heterogenicity of the acute lymphoblastic leukemias in childhood and enables their classification into groups corresponding to the early stages of lymphoblasts maturation.
Pol Tyg Lek
PMID:[Stages of B-lymphocyte differentiation in acute lymphoblastic leukemia]. 248 42

Rat kidney was studied histochemically and in electron microscope during administration of lithium carbonate for 14 days in doses of 4 mmol/l. Morphological examination demonstrated signs of damage exclusively to the epithelial cells in the proximal tubule. Histochemical examination demonstrated a major reduction of the reactions for succinate dehydrogenase and cytochrome oxidase. No difference was found in the intensity of the reaction for alkaline phosphatase and Ca-ATPase during lithium treatment as compared to controls. Additional observation demonstrated, only in histological examination, an increased number of cells of the macula densa.
Mater Med Pol
PMID:Ultrastructural and histochemical assessment of proximal renal tubule in rats during administration of lithium carbonate. 251 37

The biochemical hepatic profile analysis was performed in 252 neonatal Holstein-Friesian calves, aged from 1 to 10 days. The activities of glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma-glutamyltransferase as well as beta-glucuronidase were estimated in blood serum and in faeces. A significant decrease in glutamic oxalacetic and glutamic pyruvic transaminase, alkaline phosphatase as well as gamma-glutamyltransferase was observed in the blood serum while in the faeces the peak of activity took place between 4-5 days for beta-glucuronidase and glutamic pyruvic transaminase and 7-8 days for glutamic oxalacetic transaminase, alkaline phosphatase and gamma-glutamyltransferase. No significant relation was found between activities of the examined enzymes in blood serum and faeces. Determination of GOT and GPT, AP, GGTP in serum may be used to describe liver function in neonatal calves. No changes in total bilirubin and total protein levels in blood serum and faeces were observed during the first 10 days of calf life.
Pol Arch Weter 1989
PMID:[Biochemical profile of the liver of calves aged 1 to 10 days]. 257 37

Methodical analysis of glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma-glutamyltransferase activity in calves faeces was performed. The faeces from both healthy and diarrheic Holstein-Friesian calves, aged from 1 to 10 days, were used. For each enzyme the repetition and representativity of single determination was examined respectively in soft and dry matter. The results of our analysis show that normal enzymatic methods may be used for the determination of glutamic oxalacetic and glutamic pyruvic transaminases as well as gamma-glutamyltransferase. Further investigation methods are needed for determination of alkaline phosphatase activity in faeces.
Pol Arch Weter 1989
PMID:[Usefulness of selected enzymatic methods for coprological examination of calves]. 257 38


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