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Query: EC:3.1.3.1 (
alkaline phosphatase
)
47,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ca
v
3 / T-type Ca
2+
channels are dynamically regulated by intracellular Ca
2+
ions, which inhibit Ca
v
3 availability. Here, we demonstrate that this inhibition becomes irreversible in the presence of non-hydrolysable ATP analogs, resulting in a strong hyperpolarizing shift in the steady-state inactivation of the residual Ca
v
3 current. Importantly, the effect of these ATP analogs was prevented in the presence of intracellular BAPTA. Additional findings obtained using intracellular dialysis of inorganic phosphate and
alkaline phosphatase
or NaN
3
treatment further support the involvement of a phosphorylation mechanism. Contrasting with Ca
v
1 and Ca
v
2 Ca
2+
channels, the Ca
2+
-dependent modulation of Ca
v
3 channels appears to be independent of calmodulin,
calcineurin
and endocytic pathways. Similar findings were obtained for the native T-type Ca
2+
current recorded in rat thalamic neurons of the central medial nucleus. Overall, our data reveal a new Ca
2+
sensitive phosphorylation-dependent mechanism regulating Ca
v
3 channels, with potentially important physiological implications for the multiple cell functions controlled by T-type Ca
2+
channels.
...
PMID:A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca
2+
channels. 3166 36
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