Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:3.1.3.1 (alkaline phosphatase)
47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The sodium excess (Naes) which represents the nonexchangeable sodium compartment of bone was calculated from the total body sodium and total body chlorine of 95 women with vertebral crush fracture syndrome. No evidence was found for a subpopulation with increased or decreased Naes or Naes:TBCa ratio (TBCa is total body calcium which reflects total skeletal mass). Correlations in the osteoporotic women were found between the Naes and serum alkaline phosphatase (r = 0.31), PTH (r = 0.53), urinary hydroxyproline excretion (r = 0.42) and serum 250H vitamin D (r = -0.32). These data suggest that the state of vitamin D nutrition as well as parathyroid hormone levels may influence the quantity of sodium in bone in osteoporotic women. It is of great interest that these relationships were not observed in two control populations consisting of elderly women and women who recently underwent spontaneous menopause.
...
PMID:Sodium excess in postmenopausal osteoporosis. 641 12

Inoculation of 2 groups of dogs with 1 X 10(9) and 4 X 10(9) Leptospira interrogans serovar icterohaemorrhagiae produced disease varying from transient fever to uremia and death. Clinical signs of disease in the severely affected dogs were fever, dehydration, depression, and icterus. Laboratory changes in serum of infected dogs included increased urea nitrogen, creatinine, phosphorus, alkaline phosphatase, total bilirubin, aspartate aminotransferase, and alanine aminotransferase. Chloride concentration decreased in the serum of dogs with severe disease. The icterus in the infected dogs did not appear to be related to hemolytic anemia.
...
PMID:Serum biochemical changes in dogs with experimental Leptospira interrogans serovar icterohaemorrhagiae infection. 727 Oct 27

Chloride current activated by nicotinic acetylcholine receptors (AChR) was examined in dialysed voltage-clamp neurons of Lymnaea stagnalis. Fast superfusion of acetylcholine (ACh) evoked an inward current rapidly rising to a peak followed by a decline due to desensitization. When adenosine triphosphate with Mg2+ (MgATP, 2-10 mM) was added intracellularly the peak of the ACh-induced current was increased and its decay was slowed down. ATP without Mg2+ did not affect desensitization. Mg2+ alone accelerated desensitization. Intracellular treatment with an inhibitor of ATP synthesis, sodium arsenate, increased the desensitization rate and decreased the peak current. MgATP after arsenate wash-out restored the initial characteristics of the response; a mixture of glycolytic substrates had a similar effect. A non-hydrolysable analogue of ATP, adenosine [gamma-thio]triphosphate mimicked ATP action after arsenate removal but was weaker; another non-hydrolysable analogue, adenylyl imidodiphosphate, did not affect desensitization at all. Intracellular treatment of the neurons with alkaline phosphatase accelerated current decay. The data suggest that a change in intracellular ATP concentration modulates AChR desensitization via an enzymatic process that might be phosphorylation of AChR or some associated protein(s). Involvement of Ca2+ homeostasis cannot be excluded. The results are compared with the data obtained on vertebrate tissues under conditions promoting phosphorylation.
...
PMID:Intracellular ATP modulates desensitization of acetylcholine receptors controlling chloride current in Lymnaea neurons. 825 20

Chloride channels play an important role in the physiology and pathophysiology of epithelia, but their pharmacology is still poorly developed. We have chemically synthesized a series of substituted benzo[c]quinolizinium (MPB) compounds. Among them, 6-hydroxy-7-chlorobenzo[c]quinolizinium (MPB-27) and 6-hydroxy-10-chlorobenzo[c]quinolizinium (MPB-07), which we show to be potent and selective activators of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. We examined the effect of MPB compounds on the activity of CFTR channels in a variety of established epithelial and nonepithelial cell systems. Using the iodide efflux technique, we show that MPB compounds activate CFTR chloride channels in Chinese hamster ovary (CHO) cells stably expressing CFTR but not in CHO cells lacking CFTR. Single and whole cell patch clamp recordings from CHO cells confirm that CFTR is the only channel activated by the drugs. Ussing chamber experiments reveal that the apical addition of MPB to human nasal epithelial cells produces a large increase of the short circuit current. This current can be totally inhibited by glibenclamide. Whole cell experiments performed on native respiratory cells isolated from wild type and CF null mice also show that MPB compounds specifically activate CFTR channels. The activation of CFTR by MPB compounds was glibenclamide-sensitive and 4, 4'-diisothiocyanostilbene-2,2'-disulfonic acid-insensitive. In the human tracheal gland cell line MM39, MPB drugs activate CFTR channels and stimulate the secretion of the antibacterial secretory leukoproteinase inhibitor. In submandibular acinar cells, MPB compounds slightly stimulate CFTR-mediated submandibular mucin secretion without changing intracellular cAMP and ATP levels. Similarly, in CHO cells MPB compounds have no effect on the intracellular levels of cAMP and ATP or on the activity of various protein phosphatases (PP1, PP2A, PP2C, or alkaline phosphatase). Our results provide evidence that substituted benzo[c]quinolizinium compounds are a novel family of activators of CFTR and of CFTR-mediated protein secretion and therefore represent a new tool to study CFTR-mediated chloride and secretory functions in epithelial tissues.
...
PMID:Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel. 1048 73

Moulded and mycotoxin containing barley was incorporated into the diets for laying hens to study the effects on performance and health. Health indicators were different blood plasma parameters and liver vitamin A and E levels. A total of 30 hens were fed 3 diets, one supplemented with 30% of toxin-free and two with differently moulded barley from 1997 and 1998 for 7 weeks. The moulded diets contained low to moderate concentrations of ochratoxin A, zearalenone, deoxynivalenol and nivalenol. Inclusion of mouldy barley in the diets had an adverse effect on feed intake, feed conversion, digestibility of nutrients, egg production and egg quality. Plasma alkaline phosphatase was increased and certain biochemical blood parameters (bilirubin, uric acid, chlorine, protein, albumin, vitamin A) were also higher or changed compared to control. The ochratoxin A contamination although relatively low could have contributed to some of these effects as well as reduced intake of feed. The higher mould contamination and an unidentified cell-toxic constituent in the diet containing barley from 1998 can probably also explain the more marked effects from this diet.
...
PMID:Effects of mould and toxin contaminated barley on laying hens performance and health. 1190 78

Objective. To investigate the effect of simulated weightlessness on serum alkaline phosphatase (ALP), calcium, magnesium, chlorine and phosphorus. Method. 6 healthy males, aged 24.8 +/- 6.1, were exposed to -6 degrees HDT bed rest for 21 d. Activity of serum alkaline phosphatase, serum contents of calcium (Ca), magnesium (Mg), chlorine (Cl) and phosphorus (P) ions were assayed before HDT (d-3), on the 3rd, 10th and 21st day during HDT and after HDT (d+2). Ca was measured by methyl thymol blue method, P was determined with ultraviolet spectrophotography, determination of Mg and Cl were made with enzyme method, ALP was examined with 4-nitrobenzene phosphate method. Result. Serum Ca2+ levels were significantly higher at d10, d2l and d+2 than the value of d-3 (P<0.01). P3+ levels declined significantly on d2l as compared with d-3 (P<0.01). During the HDT and after HDT, Mg2+ declined to a level below that before HDT (P<0.05 or P<0.01). Cl- were significantly higher at d2l and d+2 than the value of d-3 (P<0.01). ALP level was higher on d2l than on d-3 (P<0.01). Conclusion. 21 d HDT induced increase of Ca, Cl, ALP, and decline of Mg and P. The changes may reflect the imbalance of metabolism.
...
PMID:[Changes of serum alkaline phosphatase and electrolytes during 21 d head down bed-rest]. 1222 72

This study examined immune cell and blood chemistry changes occurring in trained weightlifters after 1 week of rest followed by 6 weeks of Olympic-style resistance exercise. Blood was drawn weekly after 1 day of rest at the same time and on the same day of the week for 7 weeks. Lymphocyte numbers increased in weeks 5 through 7. Sodium concentration rose above entry levels in week 2, remained elevated, and peaked in week 5. Direct bilirubin dropped below baseline values in the final week. Chloride and alkaline phosphatase concentrations increased as training progressed. Chloride, potassium, albumin, CO(2), and alkaline phosphatase concentrations peaked in weeks 4 through 6. Serum creatinine was elevated in weeks 2 through 5. Data indicate that resistance training induces changes in immune cell count and blood chemistry that remain within, or near, normal clinical values. It appears that resistance training does not induce immunosuppression or negatively affect hepatic or renal function.
...
PMID:Serum chemistry and hematological adaptations to 6 weeks of moderate to intense resistance training. 1242 78

Bladder exstrophy patients with or without augmentation have not been investigated according to metabolic bone problems, bone ages and growth, and development in details yet. We studied alterations in growth, bone ages, biochemistry of bone, bone mineral densities (BMD) of the forearm, neck of femur and lumbar vertebrae, blood gases, glomerular filtration rates (GFR), and electrolytes of 15 bladder exstrophy patients with augmentation and in those who had no augmentation. In six patients, a sigmoid colon was used for bladder augmentation and one patient underwent a ureterosigmoidostomy. Growth charts of all children were analyzed for determination of the percentiles. The parameters were compared with normal children and a comparison between augmented and nonaugmented patients were made. Growth retardation and decreased bone age were detected in all of the children. Ten patients with bladder exstrophy were below the 10th percentile for height. The mean age/bone age ratio of the patients was 1.59. The mean lumbar and femoral Z scores of the patients were -1.00 and -0.49, respectively. Mean BMD for distal radius was 0.239 g/cm2. Seven patients had a marked BMD decrease, their femoral and/or lumbar Z scores were below -1. Four cases had a pH lower than 7.35. In five patients, a HCO3 level less than 19 mmol/l was detected, four of them had an augmentation. Chloride measurements were slightly increased in six patients and alkaline phosphatase levels in five cases. Reduced GFR values were detected in two patients. There were no significant difference in laboratory values, in percentile height, and weights, in BMDs of femur, vertebra, forearm nor were any differences noted in age/bone age ratios in patients with augmentation when compared with those who had no augmentation. We found varying alteration in bone mineral density and HCO3 levels in patients with bladder exstrophy. Patients with bladder exstrophy, with or without augmentation, may develop serious growth retardation. As much as 45% of them, regardless of presence of augmentation, have an osteopenia or osteoporosis. We found a considerable difference in percentiles of heights as well as bone ages in bladder exstrophy patients when compared with normal population. We recommend close follow up of children with bladder exstrophy for linear growth, development of osteopenia, and bone ages.
...
PMID:Bladder exstrophy: effects on bone age, bone mineral density, growth, and metabolism. 1566 4

Based on the recent increase in the rearing of West African Dwarf (WAD) goats in this environment, a study of biochemical parameters was carried out in healthy and infected goats to obtain baseline data for monitoring the health and productive indices in breeding programmes for the goats. The results revealed variations in some of the parameters studied. The serum minerals potassium, chlorine and bicarbonate did not show any significant differences (P>0.05) between the infected and control groups of goats, but there was a significant difference (P<0.0001) in sodium, calcium and urea levels. For serum lipids cholesterol and triglyceride, there were significant (P<0.0001) differences between the infected and control group. This goes same for serum proteins, albumin and total proteins. However, serum enzymes, serum glutamic oxaloacetic transaminase (SGOT) and gamma glutamyl transferase (GGT) were not significantly different (P>0.05) between the infected and control groups. There was a significant difference (P<0.0001) in alkaline phosphatase (ALP) and serum glutamic pyruvic transaminase (SGPT) between the infected and control groups.
...
PMID:Serological changes in goats experimentally infected with Fasciola gigantica in Buea sub-division of S.W.P. Cameroon. 1597 27

The present study reports the seasonal and physiological variations of copper, zinc, magnesium, iron, sodium chlorine, potassium, calcium, phosphorus, urea, alkaline phosphatase (ALP), creatinine (CR), aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, albumin, globulin, lactate dehydrogenase (LDH), and total protein concentrations in cattle. Two groups of mated (n = 14) and nonmated (n = 10) healthy cows were selected for the study. Serum samples were collected at each of four periods: (1) early pregnancy (May), (2) midpregnancy (August), (3) late pregnancy (October), and (4) lactation (February). Physiological variations result in changes of cholesterol, calcium, LDH, and total protein concentrations. Phosphorus varies only with seasonal but not physiological changes, whereas ALP, copper, magnesium, and potassium concentrations change with physiological and seasonal conditions. The copper concentration is increased through the pregnancy. Neither the seasonal nor the physiologic variations affect zinc, iron, sodium, chlorine, calcium, urea, creatinine, albumin, and globulin values in both groups in all periods. Thus, these values can be used as reference for both mated and nonmated bovines. The measured total protein might not reflect its true value because of dehydration during the hot season. These observations suggest that seasonal and physiologic variations have to be taken into consideration for the correct interpretation of serum chemistry and elements status in cattle. Nutritional supplements are required for cattle during certain periods to avoid a decline of their performance, which would then represent consequent economic loses.
...
PMID:Seasonal and physiological variations in serum chemistry and mineral concentrations in cattle. 1663 94


<< Previous 1 2 3 Next >>

---