Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:3.1.3.1 (alkaline phosphatase)
47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of 3 hours of methoxyflurane anesthesia in 20 dogs were determined by blood urea nitrogen (BUN), serum creatinine (SC), serum alanine aminotransferase (ALT), serum alkaline phosphatase (ALP). sulfobromphthalein (BSP), phenosulfonphthalein (PSP) clearance test, 24-hour water intake and urine excretion, and serum inorganic fluoride (SIF) evaluation. Values for BUN, SC, serum ALT, BSP, and PSP after the anesthetic were not significantly different (P less than 0.05) from the base-line values. The serum ALP values were significantly increased (P less than 0.001). Water intake and urine excretion showed a peak increase 48 hours after anesthesia. Serum inorganic fluoride concentration increased significantly (P less than 0.001) compared with the base line. The SIF 20 minutes before anesthesia was 4.54 +/- 0.82 mumol/L, at 90 minutes of surgical anesthesia 92.35 +/- 8.91 micronmol/L, at 20 minutes after anesthesia 132 +/- 12.55 micronmol/L, and at 1, 3, and 6 days after anesthesia they were 105.60 +/- 8.93, 42.10 +/- 6.90, and 12.65 +/- 1.32 micronmol/L. Clinical signs of renal or hepatic failure were not detected in any of the treated dogs during 7 day post-anesthetic observation period.
...
PMID:Serum fluoride concentration, renal, and hepatic function test results in dogs with methoxyflurane anesthesia. 88 22

Studied were the activity and properties of alkaline phosphatase (AP) in the seminal plasma, spermatozoa washed with physiologic saline, testes, and accessory sexual glands of a bull. The AP activity was highest in the seminal plasma (2493.2 IU/l) and lowest in the Kupffer gland (257.3 IU/kg crude tissue, on an average). In washed spermatozoa it proved by 10 per cent lower than the activity in seminal plasma. At 56 degrees C as much as 60-80 per cent of the AP in the investigated materials was inactivated for 30 min. AP was shown to be inactivated strongly (up to 84-97 per cent) by urea (3.8 M). L-arginine (10(-2) M) and EDTA (10(-3) M) inactivated to an equal extent AP in all studied organs. L-phenylalanine inactivated AP weakly (13-15 per cent) in the testis and the epididymis, and more strongly (32-57 per cent) in the accessory glands and the plasma. Agar electrophoresis revealed three to four isoenzymes of AP in the seminal plasma, three isoenzymes in the testis and the epididymis, and two isoenzymes in the accessory sexual glands and in spermatozoa washed with physioogic saline.
...
PMID:[Studies of the alkaline phosphatase in the sperm, testes and accessory sex glands of bulls]. 90 9

Cerebrospinal fluid (CSF) samples were collected from the atlanto-occipital (AO) and lumbosacral (LS) subarachnoid spaces of 24 horses and 21 ponies that had no clinical evidence of neurologic disease. Depth of needle insertion, pressures, refractive index, rapid reagent strip test (protein, glucose, blood, pH) results, cell counts, content of protein, glucose, sodium, potassium, chloride, calcium, phosphorus, urea nitrogen, and cholesterol, and activities of creatine phosphokinase, aspartate transaminase, lactic dehydrogenase, and alkaline phosphatase were determined. The resulting clinical reference values obtained were discussed in light of the published normal values for CSF from horses, other animals, and man. White cell counts in CSF were found to be from 0 to 6/microliters. Values for protein content were distributed between wider limits than previously reported values. The LS-AO difference is proposed as a criterion for clinical evaluation of CSF protein content. Ponies were found to have more protein in their CSF than did the horses, and CSF from the LS site contained more glucose than that from the AO site. The CSF electrolyte composition was similar to that of previous reports. Enzyme activities in equine CSF are reported for the 1st time.
...
PMID:Equine cerebrospinal fluid: reference values of normal horses. 91 Oct 95

Among 580 consecutive nonselected necropsies there were 145 cases of secondary hyperparathyroidism. In 74 instances blood concentrations of Ca2+, PO4(3-), urea, creatinine, total protein, albumin and alkaline phosphatase were available for comparison with the histomorpholgical degree of parathyroid hyperplasia matched with a control group of 32 patients with normal parathyroids. Analysis of variance revealed a significant difference in the levels of PO4 (3-) and creatinine between the normal group and that with minimal hyperplasia. Minimal and moderate diffuse parathyroid hyperplasia was associated with significant difference in calcium, phosphate, urea, creatinine, and total protein concentrations.
...
PMID:[Secondary hyperparathyroidism: comparison of clinical findings with the degree of early parathyroid hyperplasia (author's transl)]. 91 57

The normal values of serum glutamic oxaloacetic transminase, serum glutamic pyruvic transaminase, serum lactic dehydrogenase and serum alkaline phosphatase, total protein, urea, creatine, cholesterol, glucose, magnesium, calcium and inorganic phosphorus were measured monthly over a 12-month period from 10 "pure" Native and 10 Native X British Crossbred pigs. Except for cholesterol, no significant difference was found between the two groups. Similar estimations were made for 5-month and 11-month Village pigs in which the serum alkaline phosphatase, inorganic phosphorus, total protein, urea, creatinine and calcium were significantly lower when compared with the corresponding age group of the pure Native pigs and Crossbred pigs. These lower values are thought to be due to the effects of the malnutrition-parasite complex of Village pigs.
...
PMID:Some normal biochemical parameters of pigs in Pupua New Guinea. 93 99

Enzyme survey specimens were prepared by spiking portions of a normal serum pool with creatinine, urea, and five enzymes (lactate dehydrogenase, creatine phosphokinase, alkaline phosphatase, and aspartate and alanine aminotransferases), and preparing admixtures of the spiked pools with the original serum. This admixture technic established linear interspecimen relationships that could be confirmed by analyses for creatinine and urea nitrogen. Both ethylene glycol-stabilized liquid serum specimens and lyophilized specimens were prepared as sets of six to eight samples having six concentrations of each enzyme. The sets were distributed on five occasions to about ten laboratories that were widely separated geographically, and the specimens were analyzed by a variety of methods, by various instrumental systems, and in different reaction conditions, and results were reported in diverse units. This report describes how the analytic data obtained through the use of these specimens that were specifically designed for survey purposes can be analyzed statistically to provide meaningful assessments of laboratory performance in enzyme analyses.
...
PMID:Interlaboratory survey of enzyme analyses. I. Preliminary. 93 64

A multiple regression equation was used to predict age from seven clinical variables in 1080 apparently well female subjects. A multiple correlation coefficient of R = 0.77 was achieved by five of the variables: timed forced expiratory volume, systolic blood pressure, plasma urea nitrogen, cholesterol, and alkaline phosphatase. On the basis of selection by medical questionnaire responses and other objective criteria, 9% of the subjects were nonsmokers and healthier than the rest. These selected subjects showed a significant reduction in preducted age. Within this group, subjective perception of health was associated with differences in predicted age: poor health with an increase and good health with a decrease in functional age. This study of functional age was based on the healthiest segment of the population in order to minimize the effect of overt pathological processes on the aging rate. An association has been demonstrated between health impairment and predicted age as a measure of the aging rate.
...
PMID:A relationship between functional age and health status in female subjects. 95 Apr 48

We examined whether inter-individual differences in correlation coefficients previously found among subjects truly reflect consistent inter-individual differences or are time-related within an individual. The consitutents studied in this investigation were (a) the enzmes aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase; and (b) the non=protein nitrogen-containing constituents urea, uric acid, and creatinine. Ten healthy women were each subjected to 15 venipunctures over a five-week period (Series I), and, after a two-month interval, were again subjected to 15 venipunctures over a second five-week period (Series II). Before statistical analysis, the data were corrected for the batch-to-batch (day-to-day) arnalytical variation. There was a signiificant (P less than .05) change in the covariance structure (variances or correlation coefficients, or both) between the two series in four of the 10 subjects for the combination of enzymes, and in three other subjects for the combination of nonprotein nitrogen constitutents. Although we found a significant (P lees than .05) average intra-individual variation in the mean values from series to series in the cases of the three enzymes and urea, the magnitude of the inter-series variation in means was relatively small. CV's were: alkaline phosphatase, 3.4%; lactate dehydrogenase, 2.3+; aspartate aminotransferase, 3.3%; urea, 5.0%; uric acid, 1.0%; and creatinine, 1.2%.
...
PMID:Correlation of selected serum constitutents: 2. Consistency of intra-individual correlation values, means, and variances during four months. 97 46

The effects of cyproterone acetate (CA) on reproductive functions in normal human males were studied. 6 volunteers received 5 or 10 mg CA over a 20-week period. The treatment caused a gradual decrease in the number of spermatozoa and their motility, and an increase in the percentage of nonmotile, abnormal, and immature sperms. There was also a marked inhibition of sperm transport of motile sperm through cervical mucus, as determined by Kremer's test. Semen levels of acid phosphatase, sialic acid, and glycerylphosphorylcholine progressively decreased, though semen levels of fructose were not markedly altered. There were no marked changes in levels of SGOT, SGPT, serum alkaline phosphatase, blood urea, and hematocrit values. The possible mode of action of CA and its potential as a male contraceptive agent are discussed.
...
PMID:Effects of cyproterone acetate on reproductive functions in normal human males. 97 26

The effects of urea and heat treatments on electrophoretic pattern and activity were investigated in chicken plasma alkaline phosphatase (AP). The B band, which had a slower migrating rate to the F or S band irrespective of isozyme types, was labile to urea (4M) and heat treatments (60 degrees C, 10 min), while the F and S bands were stable to the same treatments. From these results, the genetic control of the three chicken plasma AP isozymes, i.e., F, S and B bands, was discussed. The total AP activity of the F or S type was little affected by urea treatment in spite of the unstableness of the B band. It is considered that the B band inactivated by urea restores the activity when the urea concentration was reduced. The AP activity was reduced by the heat treatment. The reduction may be primarily due to the loss of the activity of the B band.
...
PMID:Characterization of chicken plasma alkaline phosphatase isozymes by urea and heat treatments. 100 9


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>

---