Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum concentrations of the main vitamin D metabolites and of calcium, phosphate, and alkaline phosphatase were determined in each of the three trimesters of pregnancy and in simultaneously obtained maternal and cord blood at delivery in 22 epileptic women treated with diphenylhydantoin or carbamazepine alone or with a combination with one other drug. The results were compared with similarly obtained data from 22 normal pregnancies. Women in both groups received supplements of 400 IU vitamin D3 per day. All the women had 25-hydroxyvitamin D levels within the normal range for healthy adults (greater than 12 ng/ml) throughout pregnancy. The epileptic women had, however, significantly (p less than 0.05) lower median 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels and higher median 25,26-dihydroxyvitamin D values than the reference group. The 24,25-dihydroxyvitamin D concentrations did not differ significantly, but the median ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D was higher in the epileptic women at the end of pregnancy (p = 0.05). The respective differences in cord serum concentrations reflected those of the mothers at delivery. Serum calcium tended to be lower during epileptic pregnancy, but none were hypocalcemic. The alkaline phosphatase and phosphate values did not consistently differ from those of the reference women. The median alkaline phosphatase level of cord serum was slightly higher in the epileptic group, but the calcium and phosphate levels were similar to the reference values. The various biochemical parameters of the carbamazepine-treated women tended to be intermediate between those of the healthy and diphenylhydantoin-treated groups. Antiepileptic drug therapy appears to affect vitamin D metabolism and calcium homeostasis during pregnancy. The derangements may not be of major clinical significance, however, in vitamin D-supplemented and normally functioning women on long-term low-dose therapy.
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PMID:Anticonvulsant drug therapy in human pregnancy: effects on serum concentrations of vitamin D metabolites in maternal and cord blood. 609 58

Plasma concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], 24,25-dihydroxyvitamin D [24,25-(OH)2D], and 25,26-dihydroxyvitamin D [25,26-(OH)2D] were determined in 80 healthy infants of 4 days, 6 weeks, 6 months, and 12 months of age. The 4-day-old babies received breast milk, while the 6-week-old infants were either exclusively breast or formula fed. The older infants were on mixed diets and received daily vitamin D supplements. The levels were analyzed with regard to age and the concentrations of 25-hydroxyvitamin D (25OHD), calcium, phosphate, magnesium, and alkaline phosphatase and were compared with adult levels of vitamin D metabolites. The median 1,25-(OH)2D concentration was highest at 4 days of age and lowest at 6 weeks, but, except for the 6-week-old group, all had higher levels than the adults (6 weeks, P less than 0.1; others, P less than 0.01). 1,25-(OH)2D and 25OHD levels showed significant correlation only at 4 days (r = 0.74; P less than 0.0005), and there were no consistent relationships between 1,25-(OH)2D and the other variables. The median concentration of 24,25-(OH)2D was lower (P less than 0.01), while the 25,26-(OH)2D value was similar to that in the adults. Both were, however, positively related to the 25OHD level [24,25-(OH)2D, r = 0.82; 25,26-(OH)2D, r = 0.65; P less than 0.0005], as in the adults. The ratio of 24,25-(OH)2D to 25OHD was lower beyond 4 days of life than in the adults (medians, 3.4% vs. 5.1%; P less than 0.02). The data suggest that 1,25-(OH)2D synthesis has relative priority over 24,25-(OH)2D production during infancy compared with that in adulthood.
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PMID:Plasma concentrations of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25,26-dihydroxyvitamin D in the first year of life. 660 63

Plasma concentrations of the vitamin D metabolites 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D and 25,26-dihydroxyvitamin D were determined in 12 solely breast-fed infants 4 days and 6 weeks after birth. They were not exposed to sunlight, but the mothers received an average of 600 IU vitamin D2 per day during the study period. The mothers' 25-hydroxyvitamin D levels did not change significantly (medians 42 and 58 nmol/l), but the median level dropped from 26 to 15 nmol/l in the infants (P less than 0.001). There was a close correlation between maternal and infant levels at 4 days (r = 0.95). The babies with the highest initial levels showed the most marked decrease by 6 weeks. The median concentrations of 24,25-dihydroxyvitamin D and 25,26-dihydroxyvitamin D decreased similarly from 1.7 to 0.8 and 0.63 to 0.35 nmol/l respectively, (P less than 0.001). The 1,25-dihydroxyvitamin D levels were within normal limits as were plasma calcium, phosphorus, and alkaline phosphatase. The data suggest that fetal stores of vitamin D may be rapidly depleted, and that breast milk may be inadequate as the only source of vitamin D, even for breast-fed infants of vitamin D-supplemented mothers.
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PMID:Plasma concentrations of vitamin D metabolites in unsupplemented breast-fed infants. 666 45