Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of intravaginal application of nonoxynol-9 (N-9) on hematological parameters, routine liver function biochemistry (bilirubin, serum bile acid, SGOT, SGPT, GGT, alkaline phosphatase), and serum lipids (cholesterol and triglyceride) were evaluated in 10 normal women who received 150 mg N-9 daily for 14 consecutive days. Only 6 persons completed the trial (4 were excluded because of irritation and vaginal itching, moniliasis, and urinary tract infection). There was no effect of the N-9 on the tests reflecting liver function and hematologic parameters, confirming the results of B. Malyk. Reduction in serum cholesterol at the end of the trial was the only significant finding; such finding was not seen in the subjects of Malyk, who used a lower dose (115 mg) of the drug. Caution should be observed in interpreting the results of such a short-term clinical toxicity study as it does not reliably exclude the possibility of significant liver damage due to chronic clinical use of N-9 as a contraceptive agent. Common laboratory tests of "liver function" have been known to produce totally normal results inspite of the presence of extensive liver disease. Also, because only normal women have been studied, the hepatotoxic potential of N-9 in women with mild or chronic liver disease is not known. Early hepatic damage in rates given N-9 has been observed and suggests the need for continued surveillance of N-9 and evaluation of its systemic effects.
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PMID:Liver function tests in women using intravaginal spermicide nonoxynol-9. 627