Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.1.3.1 (alkaline phosphatase)
47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Roe-deer (Capreolus capreolus L. -- five animals) and fallow deer (Dama dama L. -- eleven animals) of both sexes and at different age were subject to blood examination. The deer were killed in several preserves in Bohemia during autumn and winter shootings in two years. The following blood values were determined: erythrocyte count, leucocyte count, hemoglobin content, hematocrit values, MCV, MCH, MCHC, white blood picture, total protein, its fractions (albumin, alpha-, beta-, and gamma-globulin) SGOT, SGPT, and alkaline phosphatase activities, and calcium, phoshporus, and magnesium levels. Examinations were performed in the blood collected from heart soon after the killing of the animals and the results were evaluated in relation to natural polyvalent invasions by parasites of the following species: Bicaulus sagittatus, Dictyocaulus viviparus, Paramphistomum sp., Haemonchus contortus, Ostertagia circumcincta, O. ostertagi, Trichostrongylus colubriformis, Bunostomum trigonocephalum, Nematodirus filicollis, Chabertia ovina, Oesophagostomum columbianum, Trichocephalus ovis, Eimeria auburnensis, E. faurei, and E. ninaekohlyakimovae, occurring in different intensities and species composition in individual animals of the deer tested.
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PMID:[Clinical examination of the blood of roe deer (Capreolus capreolus L.) and fallow deer (Dama dama L.) naturally invaded by parasites]. 80 92

In six animals hunted and four immobilized animals of red deer (Cervus elaphus L.) of both sexes and of different age, kept at three game preserves in Bohemia, the psychological values were ascertained: the number of erythrocytes and leucocytes, the hemoglobin content, the hematocrit, MCV, MCH, MCHC, the white blood count, the total serum protein, the fractions: albumin, alpha-, beta- and gamma-globulin, the activity of SGOT, and SGPT, the alkaline phosphatase and the metabolism of calcium, phosphorus, and magnesium in the blood serum. The blood from the heart shortly after killing of the animal was examined, and in immobilized animals the blood was taken from the vena jugularis. In the red deer, a variable intensity of the polyvalent infection of parasites of the species Dictyocaulus viviparus, Bicalulus sagittatus, Fascioloides magna, Paramphistomum spec., Haemonchus contortus, Ostertagia ostertagi, O. circumcincta, Trichostrongylus axei, Nematodirus filicollis, Chabertia ovina, and Trichocephalus globulosa was found. In the immobilized deer no marked deviations were found in the examined values of blood that had been taken within 10 minutes after the calming of the animals.
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PMID:[Clinical examination of the blood of red deer (Cervus elaphus L.) naturally infested with parasites]. 82 34

Twenty calves were infected with 1000 metacercariae of Fasciola hepatica, the activities of 10 enzymes in plasma or serum were assayed and concentrations in serum of proteins, urea and bilirubin were determined. These values were compared with control data obtained from 14 uninfected calves. Aspartate aminotransferase, lactate dehydrogenase, sorbitol dehydrogenase, glutamate dehydrogenase, ornithine carbamoyl transferase and gamma-glutamyl transpeptidase activities increased in infected calves. Total serum protein increased, albumin decreased, globulin increased and the albumin/globulin ratio was decreased in infected calves. Plasma alanine aminotransferase, leucine aminopeptidase, alkaline phosphatase and cholinesterase activities and serum concentration of urea and bilirubin were unaffected. It was concluded that glutamate dehydrogenase and gamma-glutamyl transpeptidase were the most sensitive indicators of liver cell damage in fascioliasis.
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PMID:Biochemical indicators of liver injury in calves with experimental fascioliasis. 83 11

Circulating levels of 25-OH vitamin D were measured in 44 patients who had undergone small intestinal bypass for obesity. Sixty-one percent had low circulating levels of the metabolite, which tended to normalize with time. This adaptive response also occurred for circulating total calcium, magnesium, albumin, and alkaline phosphatase. Serum concentrations of 25-OH vitamin D were directly related to total serum calcium and albumin. Impaired intestinal absorption of 25-OH vitamin D was seen in two patients. Following correction of total serum calcium for attendant hypoalbuminemia, 27% of patients remained hypocalcemic. The bone densities of two of 32 patients were low. In addition, skeletal biopsies of three of six patients were abnormal. It is concluded that small intestinal bypass results in at least transient deficits of circulating 25-OH vitamin D. As this operation may be associated with abnormal bone morphology, clinically significant skeletal disease may become apparent with long-term follow-up.
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PMID:Abnormalities of circulating 25-OH vitamin D after jejunal-lleal bypass for obesity: evidence of an adaptive response. 84 87

The values of a number of biochemical variables have been studied before and after a 50-gram load of glucose orally. Reductions which were statistically significant were found for sodium, potassium, urea, total protein, albumin, calcium, phosphorus, urate, bilirubin, alkaline phosphatase, but not for bicarbonate, creatinine, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, cholesterol, triglyceride or chloride. The magnitude of the changes was generally not great, but could be clinically appreciable. The differences may need to be taken into account in comparing population studies.
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PMID:The effect of 50 grams of glucose orally on a number of biochemical variables. 85 60

Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced histological evidence of slight to severe fatty degeneration of the liver lobules and Kupffer cells. In addition marked pulmonary hyperaemia and alveolar septal distention were noted. Fibrous swelling of the cardiac muscle (with striation) just barely maintained) and hyperaemia remained detectable for as long as 14 h post-exposure, but only occurred at 3000 ppm/8 h. A concentration of 1000 ppm/8 h was required to produce a fall in blood albumin, urea nitrogen, alkaline phosphatase activities and erythrocyte count. The cited concentrations failed to produce prenarcotic symptoms of narcosis (central nervous system (CNS) depression). The LD50 was found to be 6.0 ml/kg i.p. and 1.0 ml/kg p.o. for female rats, and 3.2 ml/kg i;p. for female mice. In some of the rats killed in these experiments the organ changes were found to be identical to those observed after inhalation.
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PMID:Toxicity studies on trans-1,2-dichloroethylene. 85 30

Ten subjects were exposed to high-G on the human centrifuge using seatback angles of 13 degrees, 30 degrees, 45 degrees, 60 degrees, and 75 degrees from the vertical, and body configurations of the lower portion of the body with pelvis and legs elevated, pelvis, elevated, and pelvis elevated with knees on chest (fetal position). Tolerance was measured by peripheral light loss. Mental status, respirations, core and ambient temperatures, and ECG were monitored. Daily physio-chemical data included: creatinine, bilirubin, phosphorus, alkaline phosphatase, uric acid, cholesterol, total protein, albumin, BUN, glucose, LDH cardiac isoenzyme No. 5, SGOT, SGPT, CPK, CBC, and urinalysis. Tiredness, pressure on the chest, and general discomfort in the fetal position were reported. Physical examination demonstrated petechiae. Heart rate, respiratory rate, and temperature increased post-session. There was a significant rise in values for albumin, chloride ion, creatinine, calcium, LDH, BUN, and immature white cells; and a decrease in values for phosphorus, SGOT, SGPT, protein, uric acid CO2, globulin, hematocrit, monocytes, and eosinophils.
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PMID:Psycho-physiological assessment of acceleration-induced changes in various seat configurations. 86 40

A review of 50 adult epileptics who had taken anticonvulsant drugs for 10 or more years showed a decrease in the concentration of serum phosphate and calcium and an increase in the activity of alkaline phosphatase in 22% of the patients. Plasma albumin and gamma-globulin levels were higher than in control subjects. All the patients lived at home and the dietary intake of calcium and vitamin D was often borderline normal or low. Six patients were submitted to bone biopsy and of these, 4 showed histological osteomalacia. Gastrointestinal disease did not appear to be a significant factor. None of the patients had symptoms or signs attributable to osteomalacia which does not seem to be of serious significance. All the patients were taking at least two drugs and it was not possible to assess the relative importance of the various drugs. A prospective study is needed. Measurements of serum calcium, phosphorus, and alkaline phosphatase should be performed at intervals on patients who are receiving anticonvulsant therapy. Treatment with calciferol may be indicated.
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PMID:Evidence of osteomalacia in an outpatient group of adult epileptics. 87 Mar 16

The effects of prolonged strenous exercise on the plasma concentrations of sodium, potassium, calcium, chloride, bicarbonate, phosphate, albumin, cholesterol, glucose, creatinine, bilirubin, alkaline phosphatase, creatine phosphokinase, lactic dehydrogenase and asparate amino transferase were studied in a group of 26 horses competing in an endurance ride. There were significant changes in most parameters, when control values were compared with those taken immediately after the ride. There was also a significant correlation between several biochemical parameters and heart rate taken 30 minutes after the ride. When faster and slower horses were compared, significant differences were found only in phosphate and glucose values.
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PMID:Plasma biochemistry alterations in horses during an endurance ride. 89 15

The most serious adverse effect of standard intestinal bypass for obesity is the high incidence of hepatic dysfunction and death from hepatic failure. We therefore examined the long-term effects of a modified form of jejunoileal bypass (in which a greater continuous length of ileum is retained), on liver function in 120 patients. Substantial weight loss (119-0+/-SD 23-3 kg to 82-3+/-18-8 kg) occurred during the first nine months after surgery, accompanied by a significant rise in serum concentrations of bilirubin, alanine transferase, and alkaline phosphatase, and a significant reduction in albumin concentrations. Biochemical changes were unrelated to weight loss or halothane anaesthesia. After weight stabilisation liver function reverted to normal, and four years after bypass sulphobromophthalein retention and hepatic histology did not differ from those in obese controls. There were two postoperative deaths. Three other patients died during the period of rapid weight loss with severe hepatic steatosis. While transient mild impairment of liver function is common after modified jejunoileal bypass, clinically significant hepatic dysfunction is a rare and unexplained early complication.
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PMID:Hepatic structure and function after modified jejunoileal bypass surgery for obesity. 91 71


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