Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.3.1 (alkaline phosphatase)
 47,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The observation of a non-metastatic reactive hepatopathy associated with a hypernephroma in a 39-year-old man who had had fever for 4 months led to a review of the literature and an analysis of basically three aspects of the disorder: a) The various manifestations of carcinoma of the kidney, which include a large number of paraneoplastic clinical symptoms (polycythemia, anemia, prolonged fever, hypercalcemia, hypertension, nefropathy, loss of salt, peripheral neuropathy, and amyloidosis); b) an alteracion of hepatic function known since 1961 which is characterized by an abnormal retention of sulfobromophthalein, increase of alkaline phosphatase, prothrombin decrease, dysproteinemia with hypoalbuminemia, and alpha2-globulin increase. It may or may not be accompanied by enlargement of the liver. c) Criteria of operability of the primary tumor.
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PMID:[Liver disease associated with hypernephroma. A case report (author's transl)]. 45 99

Clinico-morphological, cyto- and biochemical, cytogenetic, immunological studies were carried out in 68 patients with chronic monocytic leukemia. It was found that the main diagnostic signs of this lesion are an associated or isolated enlargement of lymph nodes, the speen and liver, persistent absolute and relative monocytosis in the peripheral blood and sternal needle biopsy specimens, multifocal or diffuse outgrowth of monocytic elements in the bone marrow trepanobiopsy specimens from the ileac bone. Also, dysproteinemia mainly on account on hypergammaglobulinemia, a rather in monocytes and the reduced activity of alkaline phosphatase in neutrophils are characteristic of chronic monocytic leukemia. The basic histomorphological manifestations of the disease are leukemic infiltration by monocytes and reticular cells of the bone marrow, of flat and tubular bones, lymphnodes, the spleen, liver and other organs.
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PMID:[Diagnosis of chronic monocytic leukemia]. 693 72